International Journal of Immunology

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Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon

Received: 21 November 2015    Accepted: 29 November 2015    Published: 22 March 2016
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Abstract

sFas (CD95) / FasL are hallmarks of apoptosis involvement in pathogenesis of HIV. We assess changes in soluble Fas /FasL, CD4 % and HIV-1 viral load in patients prior to the initiation of antiretroviral therapy (ART) and 6 months thereafter. A prospective longitudinal study on sixty consented HIV-1 positive adults. sFas and sFasL levels were measured by ELISA. CD4 cell counts and HIV-1 viralloads were measured using standard methods. Samples were analysed according to the manufacturers’ guidelines.There was a significant positive correlation between HIV-1 viral load and FasL at six months (M6) on treatment [r = +0.49, (0.03)]. There were no correlation between sFas/FasL and CD4 cell counts [ r = -33 (0.16), -31 (0.17) -23 (0.03) respectively]. The significant correlation between sFasL and HIV-1 viral load at six months of ART suggests that sFasL could be a signal biomarker for HIV-1 disease progression. We have shown in this study that high levels of sFasL depict high HIV-1 viral loads and advance state of the HIV disease. These biomarker should be investigated further in other settings.

DOI 10.11648/j.iji.20160401.11
Published in International Journal of Immunology (Volume 4, Issue 1, February 2016)
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

sFasligands (CD95), Apoptosis, HIV, AICD, ART

References
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Author Information
  • Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon

  • Department of Public Health, Faculty of Health Sciences, University of Buea, Buea, Cameroon

  • Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

  • Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon

  • Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon

  • Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon

  • Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon

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    George Mondinde Ikomey, Atashili Julius, Graeme Brendon Jacobs, Martha Tongo Mesembe, Agnes Eyoh, et al. (2016). Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon. International Journal of Immunology, 4(1), 1-5. https://doi.org/10.11648/j.iji.20160401.11

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    ACS Style

    George Mondinde Ikomey; Atashili Julius; Graeme Brendon Jacobs; Martha Tongo Mesembe; Agnes Eyoh, et al. Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon. Int. J. Immunol. 2016, 4(1), 1-5. doi: 10.11648/j.iji.20160401.11

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    AMA Style

    George Mondinde Ikomey, Atashili Julius, Graeme Brendon Jacobs, Martha Tongo Mesembe, Agnes Eyoh, et al. Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon. Int J Immunol. 2016;4(1):1-5. doi: 10.11648/j.iji.20160401.11

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  • @article{10.11648/j.iji.20160401.11,
      author = {George Mondinde Ikomey and Atashili Julius and Graeme Brendon Jacobs and Martha Tongo Mesembe and Agnes Eyoh and Emilia Lyonga and Okomo Assoumou Marie Claire},
      title = {Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon},
      journal = {International Journal of Immunology},
      volume = {4},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.iji.20160401.11},
      url = {https://doi.org/10.11648/j.iji.20160401.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.iji.20160401.11},
      abstract = {sFas (CD95) / FasL are hallmarks of apoptosis involvement in pathogenesis of HIV. We assess changes in soluble Fas /FasL, CD4 % and HIV-1 viral load in patients prior to the initiation of antiretroviral therapy (ART) and 6 months thereafter. A prospective longitudinal study on sixty consented HIV-1 positive adults. sFas and sFasL levels were measured by ELISA. CD4 cell counts and HIV-1 viralloads were measured using standard methods. Samples were analysed according to the manufacturers’ guidelines.There was a significant positive correlation between HIV-1 viral load and FasL at six months (M6) on treatment [r = +0.49, (0.03)]. There were no correlation between sFas/FasL and CD4 cell counts [ r = -33 (0.16), -31 (0.17) -23 (0.03) respectively]. The significant correlation between sFasL and HIV-1 viral load at six months of ART suggests that sFasL could be a signal biomarker for HIV-1 disease progression. We have shown in this study that high levels of sFasL depict high HIV-1 viral loads and advance state of the HIV disease. These biomarker should be investigated further in other settings.},
     year = {2016}
    }
    

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    T1  - Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon
    AU  - George Mondinde Ikomey
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    AU  - Martha Tongo Mesembe
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    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
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    AB  - sFas (CD95) / FasL are hallmarks of apoptosis involvement in pathogenesis of HIV. We assess changes in soluble Fas /FasL, CD4 % and HIV-1 viral load in patients prior to the initiation of antiretroviral therapy (ART) and 6 months thereafter. A prospective longitudinal study on sixty consented HIV-1 positive adults. sFas and sFasL levels were measured by ELISA. CD4 cell counts and HIV-1 viralloads were measured using standard methods. Samples were analysed according to the manufacturers’ guidelines.There was a significant positive correlation between HIV-1 viral load and FasL at six months (M6) on treatment [r = +0.49, (0.03)]. There were no correlation between sFas/FasL and CD4 cell counts [ r = -33 (0.16), -31 (0.17) -23 (0.03) respectively]. The significant correlation between sFasL and HIV-1 viral load at six months of ART suggests that sFasL could be a signal biomarker for HIV-1 disease progression. We have shown in this study that high levels of sFasL depict high HIV-1 viral loads and advance state of the HIV disease. These biomarker should be investigated further in other settings.
    VL  - 4
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