The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children

Farida Tabri; Mochammad Hatta; Khaeruddin Djawad; Siswanto Wahab; Ilhamjaya Patellongi

doi:doi:10.11648/j.iji.20160406.15

| Peer-Reviewed

The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children

Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi

Published in International Journal of Immunology (Volume 4, Issue 6)

Received: 8 December 2016 Accepted: 20 December 2016 Published: 19 January 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: IL-10 is an antiinflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages. Regulatory cytokine interleukin-10 (IL-10) has been proposed as a key molecule involved in the attenuation of helminth infection and chronic inflammation, such as atopic dermatitis. The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; currently, there is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity. The objective of this study was to measure the IL-10 level in healthy person, atopic dermatitis, helminth infection and healthy persons. Methods: Levels of IL-10 was measured by ELISA technique. Kato-Katz method is used to determine the number of eggs of helminth. Results: Our study showed that those aged > 5 years old and helminth infection without atopic dermatitis had higher levels of IL-10 (3.05 ± 2.44) which was significantly higher (p < 0.001) than in children whose atopic dermatitis without the helminth infection (1.76 ± 2.72). We found that increased levels of IL-10 in helminth infection (3.05 ± 2.44) higher than healthy subjects (1.72 ± 1.74); but not statistically significant (p = 0.072). The level of IL-10 did not have significant relationship either at age ≤ 5 years old and > 5 years old in others group. Also, no correlation between egg count of helminth and level of IL-10 in serum. Conclusion: The serum of IL-10 was significantly higher in children > 5 years with helminth infection without atopic dermatitis than children with atopic dermatitis.

Published in	International Journal of Immunology (Volume 4, Issue 6)
DOI	10.11648/j.iji.20160406.15
Page(s)	73-77
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Interleukin-10, Atopic dermatitis, Helminth Infection

References

[1]	Goldsmith L, Kats Z, Gilchrest B, Paller A, Leffel D, Wolf K. Fitzpatrick’s Dermatology in General Medicine. 8th edition. United States: The McGraw-Hill Companies, 2012.
[2]	Griffiths C, Barker J, Bleiker Tanya, Chalmers R. Atopic dermatitis. Rook’s Textbook of Dermatology 9th edition. Oxford: Wiley Blackwell Publishing, 2016.
[3]	R. Johannes, Hanifin J. Atopic Dermatitis. Baravia, Germany: Spinger International Publishing, 2016.
[4]	Bethony J, Brooker S, Albico M, Geiger SM, Loukas A, Diemert D, et al. Soil-transmitted Helminth infections: Ascariasis, trichuriasis, and Hookworm. Lancet, 2006; 367: 1521-32.
[5]	Hu. X, Lionel B. Ivashkiv. Cross Regulation of Signalling and Immune Responses by IFNγ and STAT1. Immunity, 2009;31 (4): 539-550.
[6]	Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, et al. Interleukin-10 production by Th1 cells requires interleukin -12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity, 2009; 209-219.
[7]	Kamradt, T., Goggel, R., & Erb, K. Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection. Trends in Immunology, 2006; 26 (5): 260-267.
[8]	Flohr, C. Quinell, R. & Britton, K. Do Helminth parasites protect against atopy and allergic disease? Clinical Exp Allergy, 2009; 39: 20-32.
[9]	Rusmartini, The examination technic for parasitic worm in Natadisastra, D & Agoes, R. (Eds.). Jakarta: EGC medical book publishing, 2009.
[10]	Van Riet, Hager, F. & Yazdanbakhsh, M. Chronic helminth infections induce immunomodulation: Consequences and mechanisms. Immunology, 2007; 212: 475-90.
[11]	Mosman, Tim R. "Properties and Functions of Interleukin-10." Advances in Immunology, 2005: 56; 1-26.
[12]	Anthony, R., Rutitzky, L., J., Stadecker, M. & Gause, W. Protective immune mechanisms in Helminth Infection. Nat Rev Immunol, 2007: 975-87.
[13]	Kluken, H., Wienker, T. & Beiber, T. 2003 Atopic Eczema / dermatitis syndrom genetivally complex disease. New advances in discovering the genetic contribution. Allergy, 2003; 58: 5-12.
[14]	Zdanov, A. structure and function of IL-10 and IL-10 receptor. dalam Marincola, F. (Ed). Interleukin -10. Texas, Landes Bioscience, 2006.
[15]	Gooddey NOP, Osagie ID, Maliki A. Serum cytokines profiles in Nigerian children with Ascaris lumbricoides infection. Asian Pac J Trop Med, 2010; 3: 288-91.
[16]	Bieber T: Atopic dermatitis. N Engl J Med 358, 2008: 1483.
[17]	Carvalho EM, Bastos LS, Araujo MI. Worms And Allergy. Parasite Immunol, 2006; 28: 25-534. PIM894 [Pii]. PMID: 16965288.
[18]	Cooper PJ, Chico ME, Rodriques LC, Ordonez M, Strachan, D, et al. Reduced risk of atopy among school- age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol, 2005; 111: 995-1000.
[19]	Stein M, Weismann Z, Handzel Z, Bentwich Z. Allergy and Helminthic Infections in Ethiopian immigrants to israel – increased atopy following parasites eradication? J Allergy Clin Immunol, 2004; 105[1]: S 302
[20]	Mehta RS, Rodriques A, Chico M, Guadalupe 1, Broncano N, Sandoval C, et al. Maternal geohelminth infections in children: A case- control study. Plos Neql Trop Dis, 2012; 6: e1753.
[21]	Faulkner H, Turner J, Kamqno J, pion SD, Boussinesq M, Bradley JE. Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. J infect Dis, 2002; 185: 665-72.

Cite This Article

Plain Text BibTeX RIS

APA Style

Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi. (2017). The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. International Journal of Immunology, 4(6), 73-77. https://doi.org/10.11648/j.iji.20160406.15

Copy | Download

ACS Style

Farida Tabri; Mochammad Hatta; Khaeruddin Djawad; Siswanto Wahab; Ilhamjaya Patellongi. The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. Int. J. Immunol. 2017, 4(6), 73-77. doi: 10.11648/j.iji.20160406.15

Copy | Download

AMA Style

Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi. The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. Int J Immunol. 2017;4(6):73-77. doi: 10.11648/j.iji.20160406.15

Copy | Download

@article{10.11648/j.iji.20160406.15,
  author = {Farida Tabri and Mochammad Hatta and Khaeruddin Djawad and Siswanto Wahab and Ilhamjaya Patellongi},
  title = {The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children},
  journal = {International Journal of Immunology},
  volume = {4},
  number = {6},
  pages = {73-77},
  doi = {10.11648/j.iji.20160406.15},
  url = {https://doi.org/10.11648/j.iji.20160406.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20160406.15},
  abstract = {Background: IL-10 is an antiinflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages. Regulatory cytokine interleukin-10 (IL-10) has been proposed as a key molecule involved in the attenuation of helminth infection and chronic inflammation, such as atopic dermatitis. The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; currently, there is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity. The objective of this study was to measure the IL-10 level in healthy person, atopic dermatitis, helminth infection and healthy persons. Methods: Levels of IL-10 was measured by ELISA technique. Kato-Katz method is used to determine the number of eggs of helminth. Results: Our study showed that those aged > 5 years old and helminth infection without atopic dermatitis had higher levels of IL-10 (3.05 ± 2.44) which was significantly higher (p < 0.001) than in children whose atopic dermatitis without the helminth infection (1.76 ± 2.72). We found that increased levels of IL-10 in helminth infection (3.05 ± 2.44) higher than healthy subjects (1.72 ± 1.74); but not statistically significant (p = 0.072). The level of IL-10 did not have significant relationship either at age ≤ 5 years old and > 5 years old in others group. Also, no correlation between egg count of helminth and level of IL-10 in serum. Conclusion: The serum of IL-10 was significantly higher in children > 5 years with helminth infection without atopic dermatitis than children with atopic dermatitis.},
 year = {2017}
}

Copy | Download

TY - JOUR
T1 - The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children
AU - Farida Tabri
AU - Mochammad Hatta
AU - Khaeruddin Djawad
AU - Siswanto Wahab
AU - Ilhamjaya Patellongi
Y1 - 2017/01/19
PY - 2017
N1 - https://doi.org/10.11648/j.iji.20160406.15
DO - 10.11648/j.iji.20160406.15
T2 - International Journal of Immunology
JF - International Journal of Immunology
JO - International Journal of Immunology
SP - 73
EP - 77
PB - Science Publishing Group
SN - 2329-1753
UR - https://doi.org/10.11648/j.iji.20160406.15
AB - Background: IL-10 is an antiinflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages. Regulatory cytokine interleukin-10 (IL-10) has been proposed as a key molecule involved in the attenuation of helminth infection and chronic inflammation, such as atopic dermatitis. The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; currently, there is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity. The objective of this study was to measure the IL-10 level in healthy person, atopic dermatitis, helminth infection and healthy persons. Methods: Levels of IL-10 was measured by ELISA technique. Kato-Katz method is used to determine the number of eggs of helminth. Results: Our study showed that those aged > 5 years old and helminth infection without atopic dermatitis had higher levels of IL-10 (3.05 ± 2.44) which was significantly higher (p < 0.001) than in children whose atopic dermatitis without the helminth infection (1.76 ± 2.72). We found that increased levels of IL-10 in helminth infection (3.05 ± 2.44) higher than healthy subjects (1.72 ± 1.74); but not statistically significant (p = 0.072). The level of IL-10 did not have significant relationship either at age ≤ 5 years old and > 5 years old in others group. Also, no correlation between egg count of helminth and level of IL-10 in serum. Conclusion: The serum of IL-10 was significantly higher in children > 5 years with helminth infection without atopic dermatitis than children with atopic dermatitis.
VL - 4
IS - 6
ER -

Copy | Download

Author Information

Farida Tabri

Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Mochammad Hatta

Molecular Biology & Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Khaeruddin Djawad

Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab

Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi

Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi. (2017). The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. International Journal of Immunology, 4(6), 73-77. https://doi.org/10.11648/j.iji.20160406.15

Copy | Download

ACS Style

Farida Tabri; Mochammad Hatta; Khaeruddin Djawad; Siswanto Wahab; Ilhamjaya Patellongi. The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. Int. J. Immunol. 2017, 4(6), 73-77. doi: 10.11648/j.iji.20160406.15

Copy | Download

AMA Style

Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi. The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children. Int J Immunol. 2017;4(6):73-77. doi: 10.11648/j.iji.20160406.15

Copy | Download

@article{10.11648/j.iji.20160406.15,
  author = {Farida Tabri and Mochammad Hatta and Khaeruddin Djawad and Siswanto Wahab and Ilhamjaya Patellongi},
  title = {The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children},
  journal = {International Journal of Immunology},
  volume = {4},
  number = {6},
  pages = {73-77},
  doi = {10.11648/j.iji.20160406.15},
  url = {https://doi.org/10.11648/j.iji.20160406.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20160406.15},
  abstract = {Background: IL-10 is an antiinflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages. Regulatory cytokine interleukin-10 (IL-10) has been proposed as a key molecule involved in the attenuation of helminth infection and chronic inflammation, such as atopic dermatitis. The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; currently, there is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity. The objective of this study was to measure the IL-10 level in healthy person, atopic dermatitis, helminth infection and healthy persons. Methods: Levels of IL-10 was measured by ELISA technique. Kato-Katz method is used to determine the number of eggs of helminth. Results: Our study showed that those aged > 5 years old and helminth infection without atopic dermatitis had higher levels of IL-10 (3.05 ± 2.44) which was significantly higher (p < 0.001) than in children whose atopic dermatitis without the helminth infection (1.76 ± 2.72). We found that increased levels of IL-10 in helminth infection (3.05 ± 2.44) higher than healthy subjects (1.72 ± 1.74); but not statistically significant (p = 0.072). The level of IL-10 did not have significant relationship either at age ≤ 5 years old and > 5 years old in others group. Also, no correlation between egg count of helminth and level of IL-10 in serum. Conclusion: The serum of IL-10 was significantly higher in children > 5 years with helminth infection without atopic dermatitis than children with atopic dermatitis.},
 year = {2017}
}

Copy | Download