Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates
International Journal of Genetics and Genomics
Volume 2, Issue 4, August 2014, Pages: 57-61
Received: Jul. 25, 2014; Accepted: Aug. 6, 2014; Published: Aug. 20, 2014
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Authors
Barbara Picone, Department of Genetics, University of Stellenbosch, Stellenbosch, 7602, South Africa; South African National Bioinformatics Institute (SANBI), SA Medical Research Council Bioinformatics Unit, University Western Cape, Bellville, 7535, South Africa
Alan Christoffels, South African National Bioinformatics Institute (SANBI), SA Medical Research Council Bioinformatics Unit, University Western Cape, Bellville, 7535, South Africa
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Abstract
African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.
Keywords
Receptor Genes, Tuberculosis, Phylogeny, Non-Human Primates, Adaptive Evolution
To cite this article
Barbara Picone, Alan Christoffels, Molecular Evolution of Key Receptor Genes in Primates and Non-Human Primates, International Journal of Genetics and Genomics. Vol. 2, No. 4, 2014, pp. 57-61. doi: 10.11648/j.ijgg.20140204.12
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