International Journal of Genetics and Genomics

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Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women

Received: 15 July 2015    Accepted: 23 July 2015    Published: 01 August 2015
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Abstract

While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.

DOI 10.11648/j.ijgg.20150304.11
Published in International Journal of Genetics and Genomics (Volume 3, Issue 4, August 2015)
Page(s) 36-42
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Breast, Benign, Tumors, Cytochrome b, Variability, Evolution, Senegal

References
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Author Information
  • Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal

  • Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal; Sudanian Sahel Animal Populations Biology (BIOPASS), Research Institute for Development, IRD / Bel-Air, Senegal

  • Cancer Institut, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Cancer Institut, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal

  • Sudanian Sahel Animal Populations Biology (BIOPASS), Research Institute for Development, IRD / Bel-Air, Senegal

  • Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal; Sudanian Sahel Animal Populations Biology (BIOPASS), Research Institute for Development, IRD / Bel-Air, Senegal

Cite This Article
  • APA Style

    Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. (2015). Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. International Journal of Genetics and Genomics, 3(4), 36-42. https://doi.org/10.11648/j.ijgg.20150304.11

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    ACS Style

    Daniel Doupa; Jean Luc Faye; Fatimata Mbaye; Sidy Ka; Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int. J. Genet. Genomics 2015, 3(4), 36-42. doi: 10.11648/j.ijgg.20150304.11

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    AMA Style

    Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int J Genet Genomics. 2015;3(4):36-42. doi: 10.11648/j.ijgg.20150304.11

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  • @article{10.11648/j.ijgg.20150304.11,
      author = {Daniel Doupa and Jean Luc Faye and Fatimata Mbaye and Sidy Ka and Ahmadou Dem and Mamadou Kane and Mbacké Sembène},
      title = {Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women},
      journal = {International Journal of Genetics and Genomics},
      volume = {3},
      number = {4},
      pages = {36-42},
      doi = {10.11648/j.ijgg.20150304.11},
      url = {https://doi.org/10.11648/j.ijgg.20150304.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijgg.20150304.11},
      abstract = {While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.},
     year = {2015}
    }
    

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    T1  - Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women
    AU  - Daniel Doupa
    AU  - Jean Luc Faye
    AU  - Fatimata Mbaye
    AU  - Sidy Ka
    AU  - Ahmadou Dem
    AU  - Mamadou Kane
    AU  - Mbacké Sembène
    Y1  - 2015/08/01
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    DO  - 10.11648/j.ijgg.20150304.11
    T2  - International Journal of Genetics and Genomics
    JF  - International Journal of Genetics and Genomics
    JO  - International Journal of Genetics and Genomics
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    EP  - 42
    PB  - Science Publishing Group
    SN  - 2376-7359
    UR  - https://doi.org/10.11648/j.ijgg.20150304.11
    AB  - While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.
    VL  - 3
    IS  - 4
    ER  - 

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