American Journal of Life Sciences

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Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM

Received: 13 December 2014    Accepted: 27 December 2014    Published: 30 January 2015
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Abstract

Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.

DOI 10.11648/j.ajls.20150301.15
Published in American Journal of Life Sciences (Volume 3, Issue 1, February 2015)
Page(s) 22-26
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

ELAM-1, VCAM-1, NIDDM

References
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Cite This Article
  • APA Style

    Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. (2015). Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. American Journal of Life Sciences, 3(1), 22-26. https://doi.org/10.11648/j.ajls.20150301.15

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    ACS Style

    Mohammed E. Al-Ghurabi; Ali A. Muhi; Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am. J. Life Sci. 2015, 3(1), 22-26. doi: 10.11648/j.ajls.20150301.15

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    AMA Style

    Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am J Life Sci. 2015;3(1):22-26. doi: 10.11648/j.ajls.20150301.15

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  • @article{10.11648/j.ajls.20150301.15,
      author = {Mohammed E. Al-Ghurabi and Ali A. Muhi and Dhefaf H. Al-Mudhafar},
      title = {Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1},
      pages = {22-26},
      doi = {10.11648/j.ajls.20150301.15},
      url = {https://doi.org/10.11648/j.ajls.20150301.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.15},
      abstract = {Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result  revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM
    AU  - Mohammed E. Al-Ghurabi
    AU  - Ali A. Muhi
    AU  - Dhefaf H. Al-Mudhafar
    Y1  - 2015/01/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150301.15
    DO  - 10.11648/j.ajls.20150301.15
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 22
    EP  - 26
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150301.15
    AB  - Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result  revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

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