Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness
Clinical Medicine Research
Volume 2, Issue 4, July 2013, Pages: 68-72
Received: Jun. 18, 2013;
Published: Jul. 10, 2013
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Sara M. Gregory, Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Beth A. Parker, Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Jeffrey A. Capizzi, Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Adam S. Grimaldi, Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Priscilla M. Clarkson, School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Stephanie Moeckel-Cole, School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Justin Keadle, School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Stuart Chipkin, School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Linda S. Pescatello, NeagSchool of Education, University of Connecticut, Storrs, CT, USA
Kathleen Simpson, NeagSchool of Education, University of Connecticut, Storrs, CT, USA
C. Michael White, NeagSchool of Education, University of Connecticut, Storrs, CT, USA
Paul D. Thompson, Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women). 25OHD status was defined as deficient (DEF: 25OHD <50 nmol•L-1, n = 16), insufficient (INS: 25OHD > 50 nmol•L-1 but < 75 nmol•L-1, n = 57), and sufficient (SUF: 25OHD >75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest: < -17.5 nmol•L-1, n = 67; middle: -17.5 to 9.1 nmol•L-1, n = 75; highest: > 9.1 nmol•L-1, n = 71). Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness. Aerobic fitnessis not impacted by temporal variations in 25OHD.
Sara M. Gregory,
Beth A. Parker,
Jeffrey A. Capizzi,
Adam S. Grimaldi,
Priscilla M. Clarkson,
Linda S. Pescatello,
C. Michael White,
Paul D. Thompson,
Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness, Clinical Medicine Research.
Vol. 2, No. 4,
2013, pp. 68-72.
Barlow, C.E., et al., Cardiorespiratory fitness and long-term survival in "low-risk" adults. J Am Heart Assoc, 2012. 1(4): p. e001354.
Lyerly, G.W., et al., The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus. Mayo Clin Proc, 2009. 84(9): p. 780-6.
Vigen, R., et al., Association of cardiorespiratory fitness with total, cardiovascular, and noncardiovascular mortality across 3 decades of follow-up in men and women. Circ Cardiovasc Qual Outcomes, 2012. 5(3): p. 358-64.
Williams, P.T., Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity. Am J Cardiol, 2010. 106(2): p. 210-5.
Shook, R.P., et al., Cardiorespiratory fitness reduces the risk of incident hypertension associated with a parental history of hypertension. Hypertension, 2012. 59(6): p. 1220-4.
Karakas, M., et al., Low Levels of Serum 25-Hydroxyvitamin D Are Associated with Increased Risk of Myocardial Infarction, Especially in Women: Results from the MONICA/KORA Augsburg Case-Cohort Study. J Clin Endocrinol Metab, 2012.
Giovannucci, E., et al., 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med, 2008. 168(11): p. 1174-80.
Dobnig, H., et al., Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med, 2008. 168(12): p. 1340-9.
Ardestani, A., et al., Relation of vitamin D level to maximal oxygen uptake in adults. Am J Cardiol, 2011. 107(8): p. 1246-9.
Grimaldi, A.S., et al., 25(OH) Vitamin D Is Associated with Greater Muscle Strength in Healthy Men and Women. Med Sci Sports Exerc, 2013. 45(1): p. 157-62.
Farrell, S.W., J.P. Cleaver, and B.L. Willis, Cardiorespiratory fitness, adiposity, and serum 25-dihydroxyvitamin d levels in men. Med Sci Sports Exerc, 2011. 43(2): p. 266-71.
Farrell, S.W. and B.L. Willis, Cardiorespiratory fitness, adiposity, and serum 25-dihydroxyvitamin D levels in women: the Cooper Center Longitudinal Study. J Womens Health (Larchmt), 2012. 21(1): p. 80-6.
Petchey, W.G., et al., Cardiorespiratory fitness is independently associated with 25-hydroxyvitamin D in chronic kidney disease. Clin J Am Soc Nephrol, 2011. 6(3): p. 512-8.
Chen, K.Y., et al., Predicting energy expenditure of physical activity using hip- and wrist-worn accelerometers. Diabetes Technol Ther, 2003. 5(6): p. 1023-33.
American College of Sports, M., ed. ACSM's Guidelines for Exercise Testing and Prescription. 8th ed. 2010, Lippincott Williams and Wilkins.
Howley, E.T., D.R. Bassett, Jr., and H.G. Welch, Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc, 1995. 27(9): p. 1292-301.
Lavie, C.J., J.H. Lee, and R.V. Milani, Vitamin D and cardiovascular disease will it live up to its hype? J Am Coll Cardiol, 2011. 58(15): p. 1547-56.
Holick, M.F., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011. 96(7): p. 1911-30.
Brandenburg, V.M., M.G. Vervloet, and N. Marx, The role of vitamin D in cardiovascular disease: From present evidence to future perspectives. Atherosclerosis, 2012.
Mitsuhashi, T., R.C. Morris, Jr., and H.E. Ives, 1,25-dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells. J Clin Invest, 1991. 87(6): p. 1889-95.
Bischoff, H.A., et al., In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J, 2001. 33(1): p. 19-24.
Houston, D.K., et al., Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci, 2007. 62(4): p. 440-6.
Ward, K.A., et al., Vitamin D status and muscle function in post-menarchal adolescent girls. J Clin Endocrinol Metab, 2009. 94(2): p. 559-63.
Jones, G., Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr, 2008. 88(2): p. 582S-586S.
Heil, D.P., Predicting activity energy expenditure using the Actical activity monitor. Res Q Exerc Sport, 2006. 77(1): p. 64-80.
Hooker, S.P., et al., Validation of the actical activity monitor in middle-aged and older adults. J Phys Act Health, 2011. 8(3): p. 372-81.