Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis

Rigen Wu; Zhiqiang Kang

doi:doi:10.11648/j.cmr.20160504.13

| Peer-Reviewed

Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis

Rigen Wu, Zhiqiang Kang

Published in Clinical Medicine Research (Volume 5, Issue 4)

Received: 14 June 2016 Accepted: Published: 15 June 2016

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.

Published in	Clinical Medicine Research (Volume 5, Issue 4)
DOI	10.11648/j.cmr.20160504.13
Page(s)	77-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Brain Retractor, Brain Retraction, Lactic Acid, Glycerol, Biochemical Metabolism, Microdialysis

References

[1]	Badr AE, Yin W, Mychaskiw G, Zhang JH. Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion. Brain Res 2001, 916: 85-90.
[2]	McClelland HM. Retraction of "Celik S., Aksoy G., Akyolcu N. (2004) Nursing role on preventing secondary brain injury. Accident & Emergency Nursing, 12(2), 94-98". Accid Emerg Nurs 2007, 15: 72.
[3]	Maurer MH. Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF). Mass Spectrom Rev 2010, 29: 17-28.
[4]	Xu W, Mellergard P, Ungerstedt U, Nordstrom CH. Local changes in cerebral energy metabolism due to brain retraction during routine neurosurgical procedures. Acta Neurochir (Wien) 2002, 144: 679-683.
[5]	Lorenz MW, Thoelen N, Loesel N, Lienerth C, Gonzalez M, Humpich M, et al. Assessment of cerebral autoregulation with transcranial Doppler sonography in poor bone windows using constant infusion of an ultrasound contrast agent. Ultrasound Med Biol 2008, 34: 345-353.
[6]	Wise BL. A review of brain retraction and recommendations for minimizing intraoperative brain injury. Neurosurgery 1994, 35: 172-173.
[7]	Andrews RJ, Bringas JR. A review of brain retraction and recommendations for minimizing intraoperative brain injury. Neurosurgery 1993, 33: 1052-1063; discussion 1063-1054.
[8]	Zhong J, Dujovny M, Perlin AR, Perez-Arjona E, Park HK, Diaz FG. Brain retraction injury. Neurol Res 2003, 25: 831-838.
[9]	Bennett MH, Albin MS, Bunegin L, Dujovny M, Hellstrom H, Jannetta PJ. Evoked potential changes during brain retraction in dogs. Stroke 1977, 8: 487-492.
[10]	Uno J, Kuwabara S, Fukuda M, Ishikawa S. [Experimental study of brain stem infarction in dogs--effect on BAEP, SSEP, blink reflex and EEG of perforator occlusion]. No To Shinkei 1988, 40: 993-999.
[11]	Lubnin A, Luk'ianov VI, Salalykin VI, Makhmudov UB. [The retraction pressure during neurosurgical operations on the brain. III. An analysis of the efficacy of prophylactic methods aimed at reducing brain volume]. Zh Vopr Neirokhir Im N N Burdenko 1995: 21-25.
[12]	Lubnin A, Korshunov AG, Sazonova OB, Goriachev AS, Salalykin VI, Makhmudov UB. [The retraction pressure in neurosurgical operations on the brain. II. An analysis of the complications related to the use of retractors]. Zh Vopr Neirokhir Im N N Burdenko 1995: 20-22.
[13]	Yokoh A, Sugita K, Kobayashi S. Intermittent versus continuous brain retraction. An experimental study. J Neurosurg 1983, 58: 918-923.
[14]	Bittigau P, Sifringer M, Felderhoff-Mueser U, Hansen HH, Ikonomidou C. Neuropathological and biochemical features of traumatic injury in the developing brain. Neurotox Res 2003, 5: 475-490.
[15]	Wu ZJ, Cai RL, Long DH, He L, Hu L. [Effects of electroacupuncture of "Shenmen" (HT 7) and "Taixi" (KI 3) on cardiac sympathetic activities in acute myocardial ischemia rabbits]. Zhen Ci Yan Jiu 2010, 35: 32-36.
[16]	Chatzipanteli K, Alonso OF, Kraydieh S, Dietrich WD. Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: biochemical and immunocytochemical studies. J Cereb Blood Flow Metab 2000, 20: 531-542.
[17]	Halperin JA, Martin AM, Malave S. Increased digitalis-like activity in human cerebrospinal fluid after expansion of the extracellular fluid volume. Life Sci 1985, 37: 561-566.
[18]	Clow KA, Ewart KV, Driedzic WR. Low temperature directly activates the initial glycerol antifreeze response in isolated rainbow smelt (Osmerus mordax) liver cells. Am J Physiol Regul Integr Comp Physiol 2008, 295: R961-970.
[19]	Retraction notice to "the protective mechanism of progesterone on blood-brain barrier in cerebral ischemia in rats" Brain Research Bulletin 79 (2009) 426-430. Brain Res Bull 2010, 81: 524.
[20]	Zhong J, Dujovny M, Perlin AR, Perez-Arjona E, Park HK, Diaz FG. Brain retraction injury. Neurol Res 2003, 25: 831-838.

Cite This Article

Plain Text BibTeX RIS

APA Style

Rigen Wu, Zhiqiang Kang. (2016). Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clinical Medicine Research, 5(4), 77-81. https://doi.org/10.11648/j.cmr.20160504.13

Copy | Download

ACS Style

Rigen Wu; Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin. Med. Res. 2016, 5(4), 77-81. doi: 10.11648/j.cmr.20160504.13

Copy | Download

AMA Style

Rigen Wu, Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin Med Res. 2016;5(4):77-81. doi: 10.11648/j.cmr.20160504.13

Copy | Download

@article{10.11648/j.cmr.20160504.13,
  author = {Rigen Wu and Zhiqiang Kang},
  title = {Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {4},
  pages = {77-81},
  doi = {10.11648/j.cmr.20160504.13},
  url = {https://doi.org/10.11648/j.cmr.20160504.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160504.13},
  abstract = {In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis
AU  - Rigen Wu
AU  - Zhiqiang Kang
Y1  - 2016/06/15
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160504.13
DO  - 10.11648/j.cmr.20160504.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160504.13
AB  - In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.
VL  - 5
IS  - 4
ER  -

Copy | Download

Author Information

Rigen Wu

Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Zhiqiang Kang

Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Rigen Wu, Zhiqiang Kang. (2016). Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clinical Medicine Research, 5(4), 77-81. https://doi.org/10.11648/j.cmr.20160504.13

Copy | Download

ACS Style

Rigen Wu; Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin. Med. Res. 2016, 5(4), 77-81. doi: 10.11648/j.cmr.20160504.13

Copy | Download

AMA Style

Rigen Wu, Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin Med Res. 2016;5(4):77-81. doi: 10.11648/j.cmr.20160504.13

Copy | Download

@article{10.11648/j.cmr.20160504.13,
  author = {Rigen Wu and Zhiqiang Kang},
  title = {Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {4},
  pages = {77-81},
  doi = {10.11648/j.cmr.20160504.13},
  url = {https://doi.org/10.11648/j.cmr.20160504.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160504.13},
  abstract = {In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis
AU  - Rigen Wu
AU  - Zhiqiang Kang
Y1  - 2016/06/15
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160504.13
DO  - 10.11648/j.cmr.20160504.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160504.13
AB  - In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.
VL  - 5
IS  - 4
ER  -

Copy | Download