Management of Arsenicosis by Intake of Proper Foods and Vitamin C Supplementation
International Journal of Nutrition and Food Sciences
Volume 4, Issue 6, November 2015, Pages: 676-680
Received: Sep. 28, 2015;
Accepted: Oct. 11, 2015;
Published: Nov. 19, 2015
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A. K. B. Zaman, Department of Dermatology, Barind Medical Collage, Rajshahi, Bangladesh
Md Fazlul Haque, Departemnt of Zoology, Rajshahi University, Rajshahi, Bangladesh
Arsenicosis, a disease caused by toxicity of arsenic, has been reported as a severe global health threat for the millions of peoples who are bound to use arsenic contaminated ground water as the main source of drinking water. Arsenicosis can be managed by using synthetic remedies. But, most of these synthetic remedies have side effect and/or are costly for the people of poor countries where arsenicosis is more prevalent. Hence, research on an alternative strategy for management of arsenicosis is important for public health. In this study, as a strategy to manage arsenicosis, a diet regime containing proper foods and vitamin C supplementation was suggested to follow for six months by arsenicosis patients who were selected from three study areas located in northwestern districts (Nawabganj and Rajshahi) of Bangladesh. It was found that the suggested diet regime can cause significant reduction of urinary arsenic excretion, enhancement of blood hemoglobin level, and improvement of keratosis condition in investigated arsenicosis patients after following the diet regime for six months, indicating a positive role of diet regime on betterment of health condition of arsenicosis patients.
A. K. B. Zaman,
Md Fazlul Haque,
Management of Arsenicosis by Intake of Proper Foods and Vitamin C Supplementation, International Journal of Nutrition and Food Sciences.
Vol. 4, No. 6,
2015, pp. 676-680.
Human Exposure; Arsenic in Drinking Water., in Some drinking-water Disinfectants and contaminants, including Arsenic. IARC Monographs on the Evaluation of Carcinogenic risks to Humans,. 2004, World Health Organization: Lyon France. p. 60-188.
Chowdhury, U.K., et al., Groundwater arsenic contamination in Bangladesh and West Bengal, India. Environ Health Perspect, 2000. 108(5): p. 393-7.
Kumar, M. and A. Puri, A review of permissible limits of drinking water. Indian journal of occupational and environmental medicine, 2012. 16(1): p. 40.
Arsenic Calamity of Bangladesh. On-line Arsenic Page 2000; Available from: www.dainichi-consul.co.jp/english/arsen.html.
Guha Mazumder, D.N., et al., Randomized placebo-controlled trial of 2, 3-dimercaptosuccinic acid in therapy of chronic arsenicosis due to drinking arsenic-contaminated subsoil water. Clinical Toxicology, 1998. 36(7): p. 683-690.
Pandey, P., et al., Arsenic contamination in the Kanker district of central-east India: geology and health effects. Environmental geochemistry and health, 2006. 28(5): p. 409-420.
Kaur, H., et al., Co-administration of α-lipoic acid and vitamin C protects liver and brain oxidative stress in mice exposed to arsenic contaminated water. Water Quality, Exposure and Health, 2009. 1(3-4): p. 135-144.
Mehta, A. and S. Flora, Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats. Food and chemical toxicology, 2001. 39(10): p. 1029-1038.
Flora, S.J., A. Mehta, and R. Gupta, Prevention of arsenic-induced hepatic apoptosis by concomitant administration of garlic extracts in mice. Chemico-biological interactions, 2009. 177(3): p. 227-233.
Rabbani, G.H., et al., Antioxidants in detoxification of arsenic-induced oxidative injury in rabbits: preliminary results. Journal of Environmental Science and Health, Part A, 2003. 38(1): p. 273-287.
Zablotska, L.B., et al., Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh. Environ Health Perspect, 2008. 116(8): p. 1056-1062.
Flora, S., Lead in the environment: prevention and treatment. J. Environ. Biol, 2002. 23: p. 29-44.
Tahir, M., H. Rasheed, and A. Malana, Method development for arsenic analysis by modification in spectrophotometric technique. Drinking Water Engineering and Science, 2012. 5(1): p. 1-8.
Dang, T.M., Q.T. Tran, and K.V. Vu, Determination of arsenic in urine by atomic absorption spectrophotometry for biological monitoring of occupational exposure to arsenic. Toxicol Lett, 1999. 108(2-3): p. 179-83.
Karasavvas, N., et al., Vitamin C protects HL60 and U266 cells from arsenic toxicity. Blood, 2005. 105(10): p. 4004-4012.
Mazumder, D.G., Diagnosis and treatment of chronic arsenic poisoning. United Nations Synthesis Report on Arsenic in Drinking Water, 2000.
Ilmiawati, C., et al., Urinary arsenic excretion profiles and associated dietary factors in Japanese women from a coastal area in Chiba Prefecture.
Heck, J.E., et al., Dietary intake of methionine, cysteine, and protein and urinary arsenic excretion in Bangladesh. Environ Health Perspect, 2009. 117(1): p. 99-104.
Sikder, M., et al., Association between anemia and grading of arsenicosis. Journal of Pakistan Association of Dermatologists, 2008. 18: p. 202-206.
Westhoff, D., R. Samaha, and A.J. Barnes, Arsenic intoxication as a cause of megaloblastic anemia. Blood, 1975. 45(2): p. 241-246.
Heck, J.E., et al., Arsenic exposure and anemia in Bangladesh: a population-based study. Journal of Occupational and Environmental Medicine, 2008. 50(1): p. 80-87.
Myers, V.C., H.H. Beard, and B.O. Barnes, Studies in the nutritional anemia of the rat iv. the production of hemoglobinemia and polycythemia in normal animals by means of inorganic elements. Journal of Biological Chemistry, 1931. 94(1): p. 117-122.
Saha, K.C., Diagnosis of arsenicosis. Journal of Environmental Science and Health, Part A, 2003. 38(1): p. 255-272.
Keller, K.L. and N.A. Fenske, Uses of vitamins A, C, and E and related compounds in dermatology: a review. Journal of the American Academy of Dermatology, 1998. 39(4): p. 611-625.