The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women

Hiromi Saito; Maiko Kato; Akihiro Yoshida; Michitaka Naito

doi:doi:10.11648/j.jfns.20150304.11

| Peer-Reviewed

The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women

Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito

Published in Journal of Food and Nutrition Sciences (Volume 3, Issue 4)

Received: 30 April 2015 Accepted: 26 May 2015 Published: 9 June 2015

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Aim: To investigate the acute effects of the ingestion of high-fructose syrup (HFS)-containing cola in combination with a hamburger on postprandial lipid metabolism. Methods: Twelve young healthy women with apolipoprotein E phenotype 3/3 were enrolled in the study. Each subject underwent 3 test trials in a randomized crossover design. The trials were as follows: C trial, cola (350 mL, containing HFS); H trial, 1 hamburger; CH trial, cola + hamburger. Venous blood samples were collected at fasting levels and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum concentrations of triglyceride (TG), remnant-like particle (RLP)-TG, and apolipoprotein B-48 (apoB48) peaked at 2 h in the H trial and at 4 h in the CH trial. Compared with each fasting level, the serum TG concentration in the H trial was significantly increased at 1, 2, and 4 h, and it returned to the fasting level at 6 h. However, compared with each fasting level, the TG concentration in the CH trial was significantly increased at 4 and 6 h, and it did not return to the fasting level at 6 h. The serum apoB48 concentration peaked at 2 h in the H trial and at 4 h in the CH trial. The apoB48 concentration at 4 and 6 h and the incremental area under the curve for apoB48 in the CH trial tended to be higher than those in the H trial. Conclusion: The ingestion of cola in combination with a hamburger delayed and extended postprandial lipidemia in comparison with the ingestion of a hamburger only, suggesting that fructose contained in the cola exacerbates postprandial lipid metabolism.

Published in	Journal of Food and Nutrition Sciences (Volume 3, Issue 4)
DOI	10.11648/j.jfns.20150304.11
Page(s)	139-146
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fructose, Apolipoprotein B-48, Postprandial Lipidemia, Triglyceride-Rich Lipoprotein, Fast Food

References

[1]	Ministry of Agriculture, Forestry and Fisheries, Japan, 2014. http://www.maff.go.jp/j/seisan/tokusan/kansho/pdf/26sy-1.pdf (in Japanese)
[2]	Walker RW, Dumke KA, Goran MI: Fructose content in popular beverages made with and without high-fructose corn syrup. Nutrition, 2014; 30: 928-935
[3]	Te Morenga L, Mallard S, Mann J: Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ, 2012; 346: e7492
[4]	Malik VS, Pan A, Willett WC, Hu FB: Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr, 2013; 98: 1084-1102
[5]	Eshak ES, Iso H, Kokubo Y, Saito I, Yamagishi K, Inoue M, Tsugane S: Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre-based study cohort I. Am J Clin Nutr, 2012; 96: 1390-1397
[6]	Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ: Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab, 2011; 96: 1596-1605
[7]	Zilversmit DB: Atherogenesis: a postprandial phenomenon. Circulation, 1979; 60: 473-485
[8]	Saito H, Kagaya M, Suzuki M, Yoshida A, Naito M: Simultaneous ingestion of fructose with fat exacerbates postprandial exogenous lipidemia in young healthy Japanese women. J Atheroscler Thromb, 2013; 20: 591-600
[9]	Saito H, Kato M, Yoshida A, Naito M: The ingestion of a fructose-containing beverage combined with fat cream exacerbates postprandial lipidemia in young healthy women. J Atheroscler Thromb, 2015; 22: 85-94
[10]	Asano M, Fukakura N, Odachi J, Kawaraya C, Nanba A, Yasuda N, Yamamoto E: Use of Fast Foods among Young People. J Nutr Diet, 2003; 61: 47-54
[11]	Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985; 28: 412-419
[12]	Okada M, Saito T, Yoshimura H, Noguchi Y, Ito T, Sasaki H, Hama H. Surfactant-based homogeneous assay for the measurement of triglyceride concentrations in VLDL and intermediate-density lipoprotein. Clin Chem, 2005; 51: 1804-1810
[13]	Sato I, Ishikawa Y, Ishimoto A, Katsura S, Toyokawa A, Hayashi F, Kawano S, Fujioka Y, Yamashita S, Kumagai S: Significance of measuring serum concentrations of remnant lipoproteins and apolipoprotein B-48 in fasting period. J Atheroscler Thromb, 2009; 16: 12-20
[14]	Gabor J, Spain M, Kalant N: Composition of serum very-low-density and high-density lipoproteins in diabetes. Clin Chem, 1980; 26: 1261-1265
[15]	Brunzell JD, Hazzard WR, Porte D Jr, Bierman EL: Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J Clin Invest, 1973; 52: 1578-1585
[16]	Xiao C, Dash S, Morgantini C, Lewis GF: Novel role of enteral monosaccharides in intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol, 2013; 33: 1056-1062
[17]	Hudgins LC, Parker TS, Levine DM, Hellerstein MK: A dual sugar challenge test for lipogenic sensitivity to dietary fructose. J Clin Endocrinol Metab, 2011; 96: 861-868
[18]	Poti JM, Slining MM, Popkin BM: Solid fat and added sugar intake among U.S. children: The role of stores, schools, and fast food, 1994-2010. Am J Prev Med, 2013; 45: 551-559
[19]	Aeberli I, Zimmermann MB, Molinari L, Lehmann R, l'Allemand D, Spinas GA, Berneis K: Fructose intake is a predictor of LDL particle size in overweight schoolchildren. Am J Clin Nutr, 2007; 86: 1174-1178
[20]	Takeichi H, Taniguchi H, Fukinbara M, Tanaka N, Shikanai S, Sarukura N, Hsu TF, Wong Y, Yamamoto S: Sugar intakes from snacks and beverages in Japanese children. J Nutr Sci Vitaminol, 2012; 58: 113-117
[21]	Yamada M, Murakami K, Sasaki S, Takahashi Y, Okubo H: Soft drink intake is associated with diet quality even among young Japanese women with low soft drink intake. J Am Diet Assoc, 2008; 108: 1997-2004
[22]	Eshak ES, Iso H, Mizoue T, Inoue M, Noda M, Tsugane S: Soft drink, 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus. Clin Nutr, 2013; 32: 300-308
[23]	Nabeno Y, Fukuchi Y, Matsutani Y, Naito M: Influence of aging and menopause on postprandial lipoprotein responses in healthy adult women. J Atheroscler Thromb, 2007; 14: 142-150
[24]	Nabeno-Kaeriyama Y, Fukuchi Y, Hayashi S, Kimura T, Tanaka A, Naito M: Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men. Clin Chim Acta, 2010; 411: 1694-1699
[25]	Hashimoto S, Ootani K, Hayashi S, Naito M: Acute effects of shortly pre-versus postprandial aerobic exercise on postprandial lipoprotein metabolism in healthy but sedentary young women. J Atheroscler Thromb, 2011; 18: 891-900
[26]	Hashimoto S, Hayashi S, Yoshida A, Naito M: Acute effects of postprandial aerobic exercise on glucose and lipoprotein metabolism. J Atheroscler Thromb, 2013; 20: 204-213
[27]	Mihas C, Kolovou GD, Mikhailidis DP, Kovar J, Lairon D, Nordestgaard BG, Ooi TC, Perez-Martinez P, Bilianou H, Anagnostopoulou K, Panotopoulos G: Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis. Curr Vasc Pharmacol, 2011; 9: 271-280

Cite This Article

Plain Text BibTeX RIS

APA Style

Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito. (2015). The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. Journal of Food and Nutrition Sciences, 3(4), 139-146. https://doi.org/10.11648/j.jfns.20150304.11

Copy | Download

ACS Style

Hiromi Saito; Maiko Kato; Akihiro Yoshida; Michitaka Naito. The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. J. Food Nutr. Sci. 2015, 3(4), 139-146. doi: 10.11648/j.jfns.20150304.11

Copy | Download

AMA Style

Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito. The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. J Food Nutr Sci. 2015;3(4):139-146. doi: 10.11648/j.jfns.20150304.11

Copy | Download

@article{10.11648/j.jfns.20150304.11,
  author = {Hiromi Saito and Maiko Kato and Akihiro Yoshida and Michitaka Naito},
  title = {The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {3},
  number = {4},
  pages = {139-146},
  doi = {10.11648/j.jfns.20150304.11},
  url = {https://doi.org/10.11648/j.jfns.20150304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20150304.11},
  abstract = {Aim: To investigate the acute effects of the ingestion of high-fructose syrup (HFS)-containing cola in combination with a hamburger on postprandial lipid metabolism. Methods: Twelve young healthy women with apolipoprotein E phenotype 3/3 were enrolled in the study. Each subject underwent 3 test trials in a randomized crossover design. The trials were as follows: C trial, cola (350 mL, containing HFS); H trial, 1 hamburger; CH trial, cola + hamburger. Venous blood samples were collected at fasting levels and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum concentrations of triglyceride (TG), remnant-like particle (RLP)-TG, and apolipoprotein B-48 (apoB48) peaked at 2 h in the H trial and at 4 h in the CH trial. Compared with each fasting level, the serum TG concentration in the H trial was significantly increased at 1, 2, and 4 h, and it returned to the fasting level at 6 h. However, compared with each fasting level, the TG concentration in the CH trial was significantly increased at 4 and 6 h, and it did not return to the fasting level at 6 h. The serum apoB48 concentration peaked at 2 h in the H trial and at 4 h in the CH trial. The apoB48 concentration at 4 and 6 h and the incremental area under the curve for apoB48 in the CH trial tended to be higher than those in the H trial. Conclusion: The ingestion of cola in combination with a hamburger delayed and extended postprandial lipidemia in comparison with the ingestion of a hamburger only, suggesting that fructose contained in the cola exacerbates postprandial lipid metabolism.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women
AU  - Hiromi Saito
AU  - Maiko Kato
AU  - Akihiro Yoshida
AU  - Michitaka Naito
Y1  - 2015/06/09
PY  - 2015
N1  - https://doi.org/10.11648/j.jfns.20150304.11
DO  - 10.11648/j.jfns.20150304.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 139
EP  - 146
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20150304.11
AB  - Aim: To investigate the acute effects of the ingestion of high-fructose syrup (HFS)-containing cola in combination with a hamburger on postprandial lipid metabolism. Methods: Twelve young healthy women with apolipoprotein E phenotype 3/3 were enrolled in the study. Each subject underwent 3 test trials in a randomized crossover design. The trials were as follows: C trial, cola (350 mL, containing HFS); H trial, 1 hamburger; CH trial, cola + hamburger. Venous blood samples were collected at fasting levels and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum concentrations of triglyceride (TG), remnant-like particle (RLP)-TG, and apolipoprotein B-48 (apoB48) peaked at 2 h in the H trial and at 4 h in the CH trial. Compared with each fasting level, the serum TG concentration in the H trial was significantly increased at 1, 2, and 4 h, and it returned to the fasting level at 6 h. However, compared with each fasting level, the TG concentration in the CH trial was significantly increased at 4 and 6 h, and it did not return to the fasting level at 6 h. The serum apoB48 concentration peaked at 2 h in the H trial and at 4 h in the CH trial. The apoB48 concentration at 4 and 6 h and the incremental area under the curve for apoB48 in the CH trial tended to be higher than those in the H trial. Conclusion: The ingestion of cola in combination with a hamburger delayed and extended postprandial lipidemia in comparison with the ingestion of a hamburger only, suggesting that fructose contained in the cola exacerbates postprandial lipid metabolism.
VL  - 3
IS  - 4
ER  -

Copy | Download

Author Information

Hiromi Saito

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan; Department of Food Science and Nutrition, Nara Women’s University, Nara, Japan
Maiko Kato

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Akihiro Yoshida

Department of Clinical Laboratory, Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan
Michitaka Naito

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito. (2015). The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. Journal of Food and Nutrition Sciences, 3(4), 139-146. https://doi.org/10.11648/j.jfns.20150304.11

Copy | Download

ACS Style

Hiromi Saito; Maiko Kato; Akihiro Yoshida; Michitaka Naito. The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. J. Food Nutr. Sci. 2015, 3(4), 139-146. doi: 10.11648/j.jfns.20150304.11

Copy | Download

AMA Style

Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito. The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women. J Food Nutr Sci. 2015;3(4):139-146. doi: 10.11648/j.jfns.20150304.11

Copy | Download

@article{10.11648/j.jfns.20150304.11,
  author = {Hiromi Saito and Maiko Kato and Akihiro Yoshida and Michitaka Naito},
  title = {The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {3},
  number = {4},
  pages = {139-146},
  doi = {10.11648/j.jfns.20150304.11},
  url = {https://doi.org/10.11648/j.jfns.20150304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20150304.11},
  abstract = {Aim: To investigate the acute effects of the ingestion of high-fructose syrup (HFS)-containing cola in combination with a hamburger on postprandial lipid metabolism. Methods: Twelve young healthy women with apolipoprotein E phenotype 3/3 were enrolled in the study. Each subject underwent 3 test trials in a randomized crossover design. The trials were as follows: C trial, cola (350 mL, containing HFS); H trial, 1 hamburger; CH trial, cola + hamburger. Venous blood samples were collected at fasting levels and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum concentrations of triglyceride (TG), remnant-like particle (RLP)-TG, and apolipoprotein B-48 (apoB48) peaked at 2 h in the H trial and at 4 h in the CH trial. Compared with each fasting level, the serum TG concentration in the H trial was significantly increased at 1, 2, and 4 h, and it returned to the fasting level at 6 h. However, compared with each fasting level, the TG concentration in the CH trial was significantly increased at 4 and 6 h, and it did not return to the fasting level at 6 h. The serum apoB48 concentration peaked at 2 h in the H trial and at 4 h in the CH trial. The apoB48 concentration at 4 and 6 h and the incremental area under the curve for apoB48 in the CH trial tended to be higher than those in the H trial. Conclusion: The ingestion of cola in combination with a hamburger delayed and extended postprandial lipidemia in comparison with the ingestion of a hamburger only, suggesting that fructose contained in the cola exacerbates postprandial lipid metabolism.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - The Ingestion of High-Fructose Syrup-Containing Cola with a Hamburger Delays Postprandial Lipid Metabolism in Young Healthy Japanese Women
AU  - Hiromi Saito
AU  - Maiko Kato
AU  - Akihiro Yoshida
AU  - Michitaka Naito
Y1  - 2015/06/09
PY  - 2015
N1  - https://doi.org/10.11648/j.jfns.20150304.11
DO  - 10.11648/j.jfns.20150304.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 139
EP  - 146
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20150304.11
AB  - Aim: To investigate the acute effects of the ingestion of high-fructose syrup (HFS)-containing cola in combination with a hamburger on postprandial lipid metabolism. Methods: Twelve young healthy women with apolipoprotein E phenotype 3/3 were enrolled in the study. Each subject underwent 3 test trials in a randomized crossover design. The trials were as follows: C trial, cola (350 mL, containing HFS); H trial, 1 hamburger; CH trial, cola + hamburger. Venous blood samples were collected at fasting levels and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum concentrations of triglyceride (TG), remnant-like particle (RLP)-TG, and apolipoprotein B-48 (apoB48) peaked at 2 h in the H trial and at 4 h in the CH trial. Compared with each fasting level, the serum TG concentration in the H trial was significantly increased at 1, 2, and 4 h, and it returned to the fasting level at 6 h. However, compared with each fasting level, the TG concentration in the CH trial was significantly increased at 4 and 6 h, and it did not return to the fasting level at 6 h. The serum apoB48 concentration peaked at 2 h in the H trial and at 4 h in the CH trial. The apoB48 concentration at 4 and 6 h and the incremental area under the curve for apoB48 in the CH trial tended to be higher than those in the H trial. Conclusion: The ingestion of cola in combination with a hamburger delayed and extended postprandial lipidemia in comparison with the ingestion of a hamburger only, suggesting that fructose contained in the cola exacerbates postprandial lipid metabolism.
VL  - 3
IS  - 4
ER  -

Copy | Download