Cancer Research Journal

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Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma

Received: 22 July 2015    Accepted: 07 August 2015    Published: 21 August 2015
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Abstract

Mucoepidermoid carcinoma (MEC) is one of most prevalent carcinomas of salivary glands in which the histoathological grading is very important in treatment and prognosis. In this study we are going to compare mast cell density in different kinds of mucoepidermoid grading by Toluidine blue staining. Materials and Methods. Paraffin blocks of 19 cases of low grade and 21 cases of high grade mucoepidermoid carcinoma were selected and stained by toluidine blue.The number of mast cells were observed in two manners(absolute and ordinal).T student was used for absolute counting and Mann Whitney for ordinal counting. in absolute counting,we defined a number for counting, for ordinal counting, we defined an interval range for mast cell numbers. Results. In absolute Counting,the mean of mast cell density in low grade cases was 19.7+/-15.7and in high grade cases was 20.3+/-21.07and there was no significant difference between two groups(p=0.920). In ordinal counting, there was no significant difference between two groups in mast cell density(p=0.729). Conclusion. According to this study, the mast cell counting can not be used for histopathological grading of MEC

DOI 10.11648/j.crj.20150305.12
Published in Cancer Research Journal (Volume 3, Issue 5, September 2015)
Page(s) 100-103
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Mast Cell, Histopathological Grading, Mucoepidermoid Carcinoma

References
[1] Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 3rd ed., Missouri: Saunders Elsevier; 2009 p.
[2] Regezi JA, Scuibba JJ, Jordan RCK. Oral Pathology: clinical Pathology correlation. 5th ed., Missouri: Sunders Elsevier; 2008. P.203-207
[3] Seethala RR. An Update on Grading of salivary Gland Carcinomas. Head Neck Pathol. 2009;3(1): 69-77.
[4] Majidi A. Evaluation of mast cell density in differential diagnosis of Enchondroma and high grade chondrosarcoma. [Doctorate Thesis]. Iran. Dental school of Shahed University; 2009. (Persian)
[5] Seethala RR. Histologic Grading and Prognostic Biomarkers in Salivary Gland Carcinomas. Adv Anat Pathol. 2011;18(1):29-45
[6] Kumar V, Abul Abbas K, Fausto N, Mithhell R. Robbins Basic Pathology. 8th Ed, Kenedy: Saunders Elsevier; 2007p.
[7] Etemad-Moghadam Sh, Gholamhosseini A, Khorshidian A, Alaeddini M. Compasison of mast cell density in hitologic differentiation of oral squamous cell carcinoma based on three different valid grading systems j Isfahan Dent Sch 2014;9(6):509-17
[8] Aolci M, Pawanckar R, Niimi Y: Masst cell in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol 2003; 130: 216-223
[9] Parizi AC, Barbosa RL, Parizi JL, Nai GA. A comparison between the concentration of mast cell in scc of the skin and oral catity. An Bras Dematol 2010 Nov-Dec; 85(6):811-8.
[10] Mohtasham N, Babakoohi S, Salehinejad J, MontaserKouhsariL, Shakeri MT, Shojaee S et al. Mast cell density and angiogenesis in oral dysplastic epithelium and low and high grade oral squamous cell carcinoma. Acta Odontol Scand 2010;68:300-304.
[11] Vidal MI, de Oliveria Araujo IB, Gurgel CA, Pereira Fde A, vilas-Boas Ds, Ramos EA, et al. tumor Biol. 2013;34(1):309-16.Density of mast cells and microvessels in minor salivary gland tumors.
Author Information
  • Amir Alam Hospital Tehtran University of Medical Sciences, Tehran, Iran

  • Shahed University, Dentistry School, Tehran, Iran

  • Shahed University, Dentistry School, Tehran, Iran

  • Tehran University of Medical School, Tehran, Iran

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    Farzad Yazdani, Gita Rezvani, Sajad Safari, Maryam Jaberi. (2015). Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma. Cancer Research Journal, 3(5), 100-103. https://doi.org/10.11648/j.crj.20150305.12

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    ACS Style

    Farzad Yazdani; Gita Rezvani; Sajad Safari; Maryam Jaberi. Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma. Cancer Res. J. 2015, 3(5), 100-103. doi: 10.11648/j.crj.20150305.12

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    AMA Style

    Farzad Yazdani, Gita Rezvani, Sajad Safari, Maryam Jaberi. Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma. Cancer Res J. 2015;3(5):100-103. doi: 10.11648/j.crj.20150305.12

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  • @article{10.11648/j.crj.20150305.12,
      author = {Farzad Yazdani and Gita Rezvani and Sajad Safari and Maryam Jaberi},
      title = {Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma},
      journal = {Cancer Research Journal},
      volume = {3},
      number = {5},
      pages = {100-103},
      doi = {10.11648/j.crj.20150305.12},
      url = {https://doi.org/10.11648/j.crj.20150305.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.20150305.12},
      abstract = {Mucoepidermoid carcinoma (MEC) is one of most prevalent carcinomas of salivary glands in which the histoathological grading is very important in treatment and prognosis. In this study we are going to compare mast cell density in different kinds of mucoepidermoid grading by Toluidine blue staining. Materials and Methods. Paraffin blocks of 19 cases of low grade and 21 cases of high grade mucoepidermoid carcinoma were selected and stained by toluidine blue.The number of mast cells were observed in two manners(absolute and ordinal).T student was used for absolute counting and Mann Whitney for ordinal counting. in absolute counting,we defined a number for counting, for ordinal counting, we defined an interval range for mast cell numbers. Results. In absolute Counting,the mean of mast cell density in low grade cases was 19.7+/-15.7and in high grade cases was 20.3+/-21.07and there was no significant difference between two groups(p=0.920). In ordinal counting, there was no significant difference between two groups in mast cell density(p=0.729). Conclusion. According to this study, the mast cell counting can not be used for histopathological grading of MEC},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma
    AU  - Farzad Yazdani
    AU  - Gita Rezvani
    AU  - Sajad Safari
    AU  - Maryam Jaberi
    Y1  - 2015/08/21
    PY  - 2015
    N1  - https://doi.org/10.11648/j.crj.20150305.12
    DO  - 10.11648/j.crj.20150305.12
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 100
    EP  - 103
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20150305.12
    AB  - Mucoepidermoid carcinoma (MEC) is one of most prevalent carcinomas of salivary glands in which the histoathological grading is very important in treatment and prognosis. In this study we are going to compare mast cell density in different kinds of mucoepidermoid grading by Toluidine blue staining. Materials and Methods. Paraffin blocks of 19 cases of low grade and 21 cases of high grade mucoepidermoid carcinoma were selected and stained by toluidine blue.The number of mast cells were observed in two manners(absolute and ordinal).T student was used for absolute counting and Mann Whitney for ordinal counting. in absolute counting,we defined a number for counting, for ordinal counting, we defined an interval range for mast cell numbers. Results. In absolute Counting,the mean of mast cell density in low grade cases was 19.7+/-15.7and in high grade cases was 20.3+/-21.07and there was no significant difference between two groups(p=0.920). In ordinal counting, there was no significant difference between two groups in mast cell density(p=0.729). Conclusion. According to this study, the mast cell counting can not be used for histopathological grading of MEC
    VL  - 3
    IS  - 5
    ER  - 

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