Dynamics of Magnetic Nanoparticles in Newly Formed Microvascular Networks Surrounding Solid Tumours: A Parallel Programming Approach
Cancer Research Journal
Volume 4, Issue 1, January 2016, Pages: 9-23
Received: Dec. 14, 2015; Accepted: Dec. 31, 2015; Published: Jan. 21, 2016
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Paul M. Darbyshire, Computational Biophysics Group, Algenet Cancer Research, Nottingham, UK
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In this paper we extend a previous 2D parallel implementation of a continuous-discrete model of tumour-induced angiogenesis. In particular, we examine the transport and capture of magnetic nanoparticles through a newly formed vascular network of blood vessels. We demonstrate how our models can be used to describe the dynamics of magnetic nanoparticles in a microvasculature and observe that the orientation of the blood vessels with respect to the magnetic force crucially affects particle capture rates leading to heterogeneous particle distributions. In addition, efficiency of magnetic particle capture depends on the ratio between the magnetic velocity and blood vessel aspect ratio. Such simulations allow a more detailed understanding of the use of magnetic nanoparticles as a mechanism for targeted anti-cancer drug delivery.
Nanotechnology, Microvascular Network, High Performance Computing (HPC), Compute Unified Device Architecture (CUDA), Graphical Processing Unit (GPU), Parallel Processing
To cite this article
Paul M. Darbyshire, Dynamics of Magnetic Nanoparticles in Newly Formed Microvascular Networks Surrounding Solid Tumours: A Parallel Programming Approach, Cancer Research Journal. Vol. 4, No. 1, 2016, pp. 9-23. doi: 10.11648/j.crj.20160401.12
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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