Dynamics of Magnetic Nanoparticles in Newly Formed Microvascular Networks Surrounding Solid Tumours: A Parallel Programming Approach
In this paper we extend a previous 2D parallel implementation of a continuous-discrete model of tumour-induced angiogenesis. In particular, we examine the transport and capture of magnetic nanoparticles through a newly formed vascular network of blood vessels. We demonstrate how our models can be used to describe the dynamics of magnetic nanoparticles in a microvasculature and observe that the orientation of the blood vessels with respect to the magnetic force crucially affects particle capture rates leading to heterogeneous particle distributions. In addition, efficiency of magnetic particle capture depends on the ratio between the magnetic velocity and blood vessel aspect ratio. Such simulations allow a more detailed understanding of the use of magnetic nanoparticles as a mechanism for targeted anti-cancer drug delivery.
Paul M. Darbyshire,
Dynamics of Magnetic Nanoparticles in Newly Formed Microvascular Networks Surrounding Solid Tumours: A Parallel Programming Approach, Cancer Research Journal.
Vol. 4, No. 1,
2016, pp. 9-23.
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