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Papular Cutaneous Amyloidosis Associated with Multiple Myeloma

Received: 23 January 2016     Accepted: 24 February 2016     Published: 4 March 2016
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Abstract

We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.

Published in Science Journal of Clinical Medicine (Volume 5, Issue 2)
DOI 10.11648/j.sjcm.20160502.11
Page(s) 16-19
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Amyloidosis, Papular, Multiple Myeloma

References
[1] Hawkins PN. Amyloidosis. Blood Rev.1988; 2(4): 270-280.
[2] Westermark P, Benson MD, Buxbaum JN, et al. A primer of amyloid nomenclature. Amyloid. 2007; 14(3): 179-183.
[3] Jaccard A, Desport E, D. Mohty, Bridoux F. Amylose AL. Rev Med Int. 2015; 36: 89–97.
[4] Wong CK. Mucocutaneous manifestations in systemic amyloidosis. Clin Dermatol. 1990; 8: 7-12.
[5] López L, González K, Navarrete G, Novales J, Guarneros A, Cortés B, et al. Multiple myeloma and systemic amyloidosis. Int J Dermatol. 2008; 47: 165-7.
[6] Oliveira Ederson Valei Lopes de, Pozetti Ana Carolina Garcia, Pozetti Eurides Maria de Oliveira, Antonio João Roberto, Michalany Nilceo Schwery. Primary systemic amyloidosis associated with multiple myeloma. An. Bras. Dermatol. 2012; 87: 119-122.
[7] Desport E, Bridoux F, Sirac C, et al. AL Amyloidosis. Orphanet Journal of Rare Diseases. 2012; 7: 54. doi: 10.1186/1750-1172-7-54.
[8] Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003; 349: 583–596. doi: 10.1056/NEJMra023144.
[9] Serpell L C, Sunde M, Benson M D, Tennent GA, Pepys M. B, Fraser P E. The protofilament substructure of amyloid fibrils. J Mol Biol. 2000; 300: 1033–1039.
[10] Sunde M, Serpell L C, Bartlam M, Fraser P E, Pepys M B, Blake C C. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J Mol Biol.1997; 273: 729–739.
[11] Modiano P. Amyloses cutanées. Encycl Méd Chir, Dermatologie. 2003; 10: 98-720.
[12] Silverstein SR. Primary systemic amyloidosis and the dermatologist where classic skin lesions may provide the clue for early diagnosis. Dermatol Online J. 2005; 11: 5.
[13] Robert C, Aractingi S, Prost C, Verola O, Blanchet-Bardon C, Blanc F et al. Bullous amyloidosis. Report of 3 cases and review of the literature. Medicine. 1993; 72: 38-44.
[14] Fujita Y, Tsuji-Aben Y, Sato-Matsumura K C, Akiyama M, & Shimizu H. Nail dystrophy and blisters as sole manifestations in myeloma-associated amyloidosis. Journal of American Academy of Dermatology. 2006; 54: 712-714.
[15] Cholez C, Cuny J F, Pouaha J, Thomas P, Tromp G, Truchet F. Atteinte unguéale et infiltration sclérodermiforme du visage au cours d’une amylose systémique. Ann Dermatol Venereol. 2005; 132: 252–254.
[16] Robert C, Aractingi S, Prost C, Verola O, Blanchet-Bardon C, Blanc F et al. Bullous amyloidosis. Report of 3 cases and review of the litterature. Medicine 1993; 72: 38-44.
[17] Moumas E, Bridoux F, Desport E. Nephropathie amyloide AL: données cliniques, épidémiologiques et pronostiques d’une série de 41 patients. Nephrol Ther. 2009; 5: 371.
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  • APA Style

    Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. (2016). Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Science Journal of Clinical Medicine, 5(2), 16-19. https://doi.org/10.11648/j.sjcm.20160502.11

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    ACS Style

    Al-Raddadi Reem; Abbaspour Valiollah; Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci. J. Clin. Med. 2016, 5(2), 16-19. doi: 10.11648/j.sjcm.20160502.11

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    AMA Style

    Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci J Clin Med. 2016;5(2):16-19. doi: 10.11648/j.sjcm.20160502.11

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  • @article{10.11648/j.sjcm.20160502.11,
      author = {Al-Raddadi Reem and Abbaspour Valiollah and Ndiaye Maodo},
      title = {Papular Cutaneous Amyloidosis Associated with Multiple Myeloma},
      journal = {Science Journal of Clinical Medicine},
      volume = {5},
      number = {2},
      pages = {16-19},
      doi = {10.11648/j.sjcm.20160502.11},
      url = {https://doi.org/10.11648/j.sjcm.20160502.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20160502.11},
      abstract = {We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.},
     year = {2016}
    }
    

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    T1  - Papular Cutaneous Amyloidosis Associated with Multiple Myeloma
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    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
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    AB  - We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.
    VL  - 5
    IS  - 2
    ER  - 

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Author Information
  • Department of Dermatology, Saint Louis Hospital, University Paris 13, Paris, France

  • Department of Dermatology, Aristide Le Dantec Hospital, University Cheikh Anta DIOP of Dakar, Senegal BP 3001, Dakar, Senegal

  • Department of Dermatology, Aristide Le Dantec Hospital, University Cheikh Anta DIOP of Dakar, Senegal BP 3001, Dakar, Senegal

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