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Idiopathic Hypereosinophilic Syndrome/Eosinophilic Leukaemia (Case Report): A Challenge to Diagnose
Science Journal of Clinical Medicine
Volume 4, Issue 4-1, July 2015, Pages: 16-18
Received: Feb. 26, 2015; Accepted: Feb. 27, 2015; Published: Aug. 3, 2015
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Authors
Sathyavathi Alva, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
Angshuman Saha, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
Tahera Syed, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
T. M. Kariappa, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
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Abstract
Hypereosinophilic syndrome (HES) was first described by Hardy and Anderson in 1968 . HES may result either from eosinophilic differentiation of a clone of neoplastic cells or from reactive eosinophilia. It appears lightly that in many patients idiopathic HES is actually a chronic myeloproliferative disorder. There is vaguely overlapping clinico-pathological picture of HES with (Chronic eosinophilic leukaemia) CEL which often adds to diagnostic confusion. In 2001, the World Health Organization (WHO) proposed a set of criteria that distinguish CEL from HES. An evidence of genetic clonality of eosinophils or an increase in blast cells in blood or bone marrow is mandatory for diagnosis of CEL, while no specific diagnostic tests exists for HES, making it an entity of exclusion. A 36 year old female presented with intermittent fever and dry cough since two months. Clinical examination revealed mild pallor with hepatosplenomegaly. Chest examination showed bilateral basal crepitations. The patient was subjected for hematological, biochemical and radiological assessment. The peripheral smear and bone marrow aspirates revealed presence of eosinophilic precursors with predominance of eosinophiloblasts associated with eosinophilic myelocytes, metamyelocytes, a few myeloblasts and lymphocytes, the features of which are in favour of CEL. CEL, a rare myeloproliferative entity and its presentation with pulmonary manifestations is still rare in India. Hence, we present this rare entity along with review of available literature.
Keywords
Chronic Eosinophilic Leukaemia, Hypereosinophilic Syndrome, Pulmonary Manifestations
To cite this article
Sathyavathi Alva, Angshuman Saha, Tahera Syed, T. M. Kariappa, Idiopathic Hypereosinophilic Syndrome/Eosinophilic Leukaemia (Case Report): A Challenge to Diagnose, Science Journal of Clinical Medicine. Special Issue: Latest Different Concepts of Gynaecology. Vol. 4, No. 4-1, 2015, pp. 16-18. doi: 10.11648/j.sjcm.s.2015040401.14
References
[1]
Vardiman JW et al Chronic myeloproliferative diseasesand Myelodysplastic / myeloproliferative diseases. World Health Organization Classificationof Tumours. Pathology and Genetics.Tumours of Haematopoietic and Lymphoid Tumours. H. N. Jaffe ES, Stein H, Vardiman JW. Lyon, France, IARC Press: 2001, 17–31, 47–52.
[2]
Yamada Y, Rothenberg M.E, Cancelas J.A. Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukaemia. Translational Oncogenomics 2006:1
[3]
Bain B.J. British journal Hematol 1996 ;95,2-9
[4]
Babu K.V.S, Chowhan A.K, Rukmangadha N, Vengamma B, Reddy M.K. Chronic eosinophilic leukaemia : a case report. J Clin Sci Res 2012; 1 : 46-8
[5]
Brito-Babapulle F. Blood Rev, 1997 ; 11,129-45
[6]
Fletcher S and Bain B. Eosinophilic Leukaemia. British Medical Bulletin 2007; 81 & 82:115-127
[7]
Kumar A, Sinha S, Tripathi A.K. Chronic Eosinophilic Leukaemia: a case report and review of literature. Indian J Hematol, Blood Transfusion.2014, 23:112-115
[8]
Chusid, M.J., Dale, D.C., West, B.C. and Wolff, S.M.. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975 54:1–27.
[9]
Bain, B., Pierre, R., Imbert, M., Vardiman, J.W., Brunning, R.D. andFlandrin, G.2001 Chronic eosinophilic leukaemia and the hypereosinophilic syndrome. IARC Press, Lyon, France.
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