Idiopathic Hypereosinophilic Syndrome/Eosinophilic Leukaemia (Case Report): A Challenge to Diagnose
Science Journal of Clinical Medicine
Volume 4, Issue 4-1, July 2015, Pages: 16-18
Received: Feb. 26, 2015;
Accepted: Feb. 27, 2015;
Published: Aug. 3, 2015
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Sathyavathi Alva, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
Angshuman Saha, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
Tahera Syed, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
T. M. Kariappa, Department of Pathology, K. V. G. Medical College, Sullia, D. K, Karnataka, India
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Hypereosinophilic syndrome (HES) was first described by Hardy and Anderson in 1968 . HES may result either from eosinophilic differentiation of a clone of neoplastic cells or from reactive eosinophilia. It appears lightly that in many patients idiopathic HES is actually a chronic myeloproliferative disorder. There is vaguely overlapping clinico-pathological picture of HES with (Chronic eosinophilic leukaemia) CEL which often adds to diagnostic confusion. In 2001, the World Health Organization (WHO) proposed a set of criteria that distinguish CEL from HES. An evidence of genetic clonality of eosinophils or an increase in blast cells in blood or bone marrow is mandatory for diagnosis of CEL, while no specific diagnostic tests exists for HES, making it an entity of exclusion. A 36 year old female presented with intermittent fever and dry cough since two months. Clinical examination revealed mild pallor with hepatosplenomegaly. Chest examination showed bilateral basal crepitations. The patient was subjected for hematological, biochemical and radiological assessment. The peripheral smear and bone marrow aspirates revealed presence of eosinophilic precursors with predominance of eosinophiloblasts associated with eosinophilic myelocytes, metamyelocytes, a few myeloblasts and lymphocytes, the features of which are in favour of CEL. CEL, a rare myeloproliferative entity and its presentation with pulmonary manifestations is still rare in India. Hence, we present this rare entity along with review of available literature.
Chronic Eosinophilic Leukaemia, Hypereosinophilic Syndrome, Pulmonary Manifestations
To cite this article
T. M. Kariappa,
Idiopathic Hypereosinophilic Syndrome/Eosinophilic Leukaemia (Case Report): A Challenge to Diagnose, Science Journal of Clinical Medicine. Special Issue: Latest Different Concepts of Gynaecology.
Vol. 4, No. 4-1,
2015, pp. 16-18.
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