Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010

Tingting Xu; Weixia Wang; Songya Lyu

doi:doi:10.11648/j.abb.20160405.12

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Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010

Tingting Xu, Weixia Wang, Songya Lyu

Published in Advances in Bioscience and Bioengineering (Volume 4, Issue 5)

Received: 25 August 2016 Accepted: 26 September 2016 Published: 15 October 2016

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Abstract

Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.

Published in	Advances in Bioscience and Bioengineering (Volume 4, Issue 5)
DOI	10.11648/j.abb.20160405.12
Page(s)	51-58
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Coxsackievirus A16, Hand, Foot and Mouth Diseases, Phylogenetic Analysis

References

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APA Style

Tingting Xu, Weixia Wang, Songya Lyu. (2016). Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Advances in Bioscience and Bioengineering, 4(5), 51-58. https://doi.org/10.11648/j.abb.20160405.12

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ACS Style

Tingting Xu; Weixia Wang; Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv. BioSci. Bioeng. 2016, 4(5), 51-58. doi: 10.11648/j.abb.20160405.12

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AMA Style

Tingting Xu, Weixia Wang, Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv BioSci Bioeng. 2016;4(5):51-58. doi: 10.11648/j.abb.20160405.12

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@article{10.11648/j.abb.20160405.12,
  author = {Tingting Xu and Weixia Wang and Songya Lyu},
  title = {Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {4},
  number = {5},
  pages = {51-58},
  doi = {10.11648/j.abb.20160405.12},
  url = {https://doi.org/10.11648/j.abb.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20160405.12},
  abstract = {Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.},
 year = {2016}
}

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TY  - JOUR
T1  - Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010
AU  - Tingting Xu
AU  - Weixia Wang
AU  - Songya Lyu
Y1  - 2016/10/15
PY  - 2016
N1  - https://doi.org/10.11648/j.abb.20160405.12
DO  - 10.11648/j.abb.20160405.12
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 51
EP  - 58
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20160405.12
AB  - Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.
VL  - 4
IS  - 5
ER  -

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Author Information

Tingting Xu

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
Weixia Wang

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
Songya Lyu

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

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Plain Text BibTeX RIS

APA Style

Tingting Xu, Weixia Wang, Songya Lyu. (2016). Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Advances in Bioscience and Bioengineering, 4(5), 51-58. https://doi.org/10.11648/j.abb.20160405.12

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ACS Style

Tingting Xu; Weixia Wang; Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv. BioSci. Bioeng. 2016, 4(5), 51-58. doi: 10.11648/j.abb.20160405.12

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AMA Style

Tingting Xu, Weixia Wang, Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv BioSci Bioeng. 2016;4(5):51-58. doi: 10.11648/j.abb.20160405.12

Copy | Download

@article{10.11648/j.abb.20160405.12,
  author = {Tingting Xu and Weixia Wang and Songya Lyu},
  title = {Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {4},
  number = {5},
  pages = {51-58},
  doi = {10.11648/j.abb.20160405.12},
  url = {https://doi.org/10.11648/j.abb.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20160405.12},
  abstract = {Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010
AU  - Tingting Xu
AU  - Weixia Wang
AU  - Songya Lyu
Y1  - 2016/10/15
PY  - 2016
N1  - https://doi.org/10.11648/j.abb.20160405.12
DO  - 10.11648/j.abb.20160405.12
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 51
EP  - 58
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20160405.12
AB  - Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.
VL  - 4
IS  - 5
ER  -

Copy | Download