Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome
This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.
Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome, American Journal of Bioscience and Bioengineering.
Vol. 3, No. 5,
2015, pp. 114-117.
A. El-Menyar, H. Thani, E. Zakaria, A. Zarour, M. Tuma, H. AbdulRahman, A. Parchani, R. Peralta and R. Latifi, “Multiple Organ Dysfunction Syndrome (MODS): Is It Preventable or Inevitable?”, International Journal of Clinical Medicine, Vol. 3 No. 7A, 2012, pp. 722-730.
A. M. Ferreira and Y. Sakr, “Organ Dysfunction: General Approach, Epidemiology, and Organ Failure Scores,” Seminars in Respiratory and Critical Care Medicine, Vol. 32, No. 5, 2011, pp. 543-551.
M. Keel and O. Trentz, “Pathophysiology of polytrauma”, Injury, Vol. 36 No. 6, 2005, pp. 691-709.
R. Latifi, P. Rhee and R. W. G. Gruessner, “Technological Advances in Surgery, Trauma and Critical Care”, New York, Springer-Verlag New York Inc., 2015, 659 p.
D. A. Partrick, F. A. Moore, E. E. Moore, W. L. Biffl, A. Sauaia and C. C. Jr. Barnett, “The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure”, Am J Surg, Vol. 172 No. 5, 1996, pp. 425-429; discussed pp. 429-431.
J. Pontet, P. Contreras, A. Curbelo, J. Medina, S. Noveri, S. Bentancourt and E. R. Migliaro, “Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients”, J Crit Care, Vol. 18 No. 3, 2003, pp. 156-163.
R. Barton and F. B. Cerra, “The hypermetabolism. Multiple organ failure syndrome”, Chest, Vol. 96 No. 5, 1989, pp. 1153-1160.
F. B. Cerra, “Hypermetabolism, organ failure, and metabolic support”, Surgery, Vol. 101 No 1, 1987, pp. 1-14.
J. L. Vincent, “Metabolic support in sepsis and multiple organ failure: more questions than answers ... ”, Crit Care Med, Vol. 35, No. 9 Suppl, 2007, pp. S436- S40.
L. S. Kremmyda, E. Tvrzicka, B. Stankova and A. Zak, “Fatty acids as biocompounds: their role in human metabolism, health and disease: a review. part 2: fatty acid physiological roles and applications in human health and disease”, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, Vol. 155, 2011, pp. 195-218.
M. Kates, “Techniques of lipidology; isolation, analysis and identification of lipids”, Amsterdam, New York, North-Holland Pub. Co., American Elsevier, 1972, 610 p.
S. Glantz, “Primer of Biostatistics”, New York, McGraw-Hill, 1994, 473 p.
A. Andersson, C. Nälsén, S. Tengblad and B. Vessby, “Fatty acid composition of skeletal muscle reflects dietary fat composition in humans”, Am J Clin Nutr, Vol. 76 No. 6, 2002, pp. 1222-1229.
C. Hellmuth, H. Demmelmair, I. Schmitt, W. Peissner, M. Blüher and B. Koletzko, “Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition”, PLoS One, Vol. 8 No. 10, 2013, e74927.
G. T. Malcom, A. K. Bhattacharyya, M. Velez-Duran, M. A. Guzman, M. C. Oalmann and J. P. Strong, “Fatty acid composition of adipose tissue in humans: differences between subcutaneous sites”, Am J Clin Nutr, Vol. 50 No. 2, 1989, pp. 288-291.
J.T. Dodge and G.B. Phillips, “Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells”, J Lipid Res, Vol. 8 No. 6, 1967, pp. 667-675.
R. M. Dougherty, C. Galli, A. Ferro-Luzzi and J. M. Iacono, “Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA”, Am J Clin Nutr, Vol. 45 No. 2, 1987, pp. 443-455.
G. Gercken, T. Tiling, U. Brockmann and W. Schröter, “Fatty acid composition of phospholipids in erythrocytes of adults, normal newborn infants, and neonates with Rh erythroblastosis”, Pediatr Res, Vol. 6 No. 5, 1972, pp. 487-494.