American Journal of Bioscience and Bioengineering

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Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2

Received: 23 December 2015    Accepted:     Published: 23 December 2015
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Abstract

Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.

DOI 10.11648/j.bio.20150306.16
Published in American Journal of Bioscience and Bioengineering (Volume 3, Issue 6, December 2015)
Page(s) 178-182
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Xenoestrogens, Cellproliferation, Shp2, MCF-7 Cell

References
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Author Information
  • School of Pharmaceutical Sciences, Xiamen University, Xiamen, China

  • School of Pharmaceutical Sciences, Xiamen University, Xiamen, China; College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China

  • Third Institute of Oceanography, State Oceanic Administration, Xiamen, China

  • College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China

  • Third People's Hospital of Pingdu, Pingdu, China

  • Third People's Hospital of Pingdu, Pingdu, China

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  • APA Style

    Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. (2015). Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. American Journal of Bioscience and Bioengineering, 3(6), 178-182. https://doi.org/10.11648/j.bio.20150306.16

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    ACS Style

    Wenjie Liu; Qinyuan Wang; Zhaokai Wang; Defeng Wu; Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am. J. BioSci. Bioeng. 2015, 3(6), 178-182. doi: 10.11648/j.bio.20150306.16

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    AMA Style

    Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am J BioSci Bioeng. 2015;3(6):178-182. doi: 10.11648/j.bio.20150306.16

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  • @article{10.11648/j.bio.20150306.16,
      author = {Wenjie Liu and Qinyuan Wang and Zhaokai Wang and Defeng Wu and Wenhua Liu and Juan Wang},
      title = {Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2},
      journal = {American Journal of Bioscience and Bioengineering},
      volume = {3},
      number = {6},
      pages = {178-182},
      doi = {10.11648/j.bio.20150306.16},
      url = {https://doi.org/10.11648/j.bio.20150306.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bio.20150306.16},
      abstract = {Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2
    AU  - Wenjie Liu
    AU  - Qinyuan Wang
    AU  - Zhaokai Wang
    AU  - Defeng Wu
    AU  - Wenhua Liu
    AU  - Juan Wang
    Y1  - 2015/12/23
    PY  - 2015
    N1  - https://doi.org/10.11648/j.bio.20150306.16
    DO  - 10.11648/j.bio.20150306.16
    T2  - American Journal of Bioscience and Bioengineering
    JF  - American Journal of Bioscience and Bioengineering
    JO  - American Journal of Bioscience and Bioengineering
    SP  - 178
    EP  - 182
    PB  - Science Publishing Group
    SN  - 2328-5893
    UR  - https://doi.org/10.11648/j.bio.20150306.16
    AB  - Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.
    VL  - 3
    IS  - 6
    ER  - 

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