Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a clinical and public health challenge in Nigeria. This study was carried out to determine the prevalence of M. tuberculosis and rifampicin resistance in patients from five selected health facilities in Nasarawa State, Nigeria. The HIV serostatus and the CD4+ count of seropositive individuals were also determined. Using a combination of Zhiel Neelsen staining and WHO approved GeneXpert MTB/Rif device for M. tuberculosis and rifampicin resistance, the presence of M. tuberculosis in sputum samples was detected and confirmed. A total of 346 samples were analysed, out of which M. tuberculosis was detected in 91 (26.3%) samples and rifampicin resistance in 6 (6.6%) of the positive samples. HIV prevalence was found to be 46.8%, HIV and TB co-infection 39.6%, while 83.3% of the rifampicin resistance was from HIV positive cases. Tuberculosis was found to be decreasing with increase in CD4 count. Statistically, there was a significant relationship (P < 0.05), between level of education, HIV, CD4 count and TB occurrence. However, no significant relationship (P > 0.05) between gender, occupation and age with TB was observed. Our results show that tuberculosis still remains endemic in Nasarawa state with a high prevalence of HIV and that the confluence of HIV and tuberculosis increased the rate of rifampicin resistance. Provision of Tuberculosis diagnostics with the capacity to detect TB drug resistance beyond rifampicin is highly recommended.
| Published in | Science Journal of Public Health (Volume 4, Issue 3) |
| DOI | 10.11648/j.sjph.20160403.18 |
| Page(s) | 214-218 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Tuberculosis, Rifampicin Resistance, GeneXpert MTB/Rif, Human Immunodeficiency Virus, CD4 Count
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APA Style
Egbe Kingsley, Ike Anthony C., Aleruchi Chuku. (2016). Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria. Science Journal of Public Health, 4(3), 214-218. https://doi.org/10.11648/j.sjph.20160403.18
ACS Style
Egbe Kingsley; Ike Anthony C.; Aleruchi Chuku. Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria. Sci. J. Public Health 2016, 4(3), 214-218. doi: 10.11648/j.sjph.20160403.18
AMA Style
Egbe Kingsley, Ike Anthony C., Aleruchi Chuku. Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria. Sci J Public Health. 2016;4(3):214-218. doi: 10.11648/j.sjph.20160403.18
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Download@article{10.11648/j.sjph.20160403.18,
author = {Egbe Kingsley and Ike Anthony C. and Aleruchi Chuku},
title = {Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria},
journal = {Science Journal of Public Health},
volume = {4},
number = {3},
pages = {214-218},
doi = {10.11648/j.sjph.20160403.18},
url = {https://doi.org/10.11648/j.sjph.20160403.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20160403.18},
abstract = {Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a clinical and public health challenge in Nigeria. This study was carried out to determine the prevalence of M. tuberculosis and rifampicin resistance in patients from five selected health facilities in Nasarawa State, Nigeria. The HIV serostatus and the CD4+ count of seropositive individuals were also determined. Using a combination of Zhiel Neelsen staining and WHO approved GeneXpert MTB/Rif device for M. tuberculosis and rifampicin resistance, the presence of M. tuberculosis in sputum samples was detected and confirmed. A total of 346 samples were analysed, out of which M. tuberculosis was detected in 91 (26.3%) samples and rifampicin resistance in 6 (6.6%) of the positive samples. HIV prevalence was found to be 46.8%, HIV and TB co-infection 39.6%, while 83.3% of the rifampicin resistance was from HIV positive cases. Tuberculosis was found to be decreasing with increase in CD4 count. Statistically, there was a significant relationship (P 0.05) between gender, occupation and age with TB was observed. Our results show that tuberculosis still remains endemic in Nasarawa state with a high prevalence of HIV and that the confluence of HIV and tuberculosis increased the rate of rifampicin resistance. Provision of Tuberculosis diagnostics with the capacity to detect TB drug resistance beyond rifampicin is highly recommended.},
year = {2016}
}
TY - JOUR T1 - Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria AU - Egbe Kingsley AU - Ike Anthony C. AU - Aleruchi Chuku Y1 - 2016/05/13 PY - 2016 N1 - https://doi.org/10.11648/j.sjph.20160403.18 DO - 10.11648/j.sjph.20160403.18 T2 - Science Journal of Public Health JF - Science Journal of Public Health JO - Science Journal of Public Health SP - 214 EP - 218 PB - Science Publishing Group SN - 2328-7950 UR - https://doi.org/10.11648/j.sjph.20160403.18 AB - Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a clinical and public health challenge in Nigeria. This study was carried out to determine the prevalence of M. tuberculosis and rifampicin resistance in patients from five selected health facilities in Nasarawa State, Nigeria. The HIV serostatus and the CD4+ count of seropositive individuals were also determined. Using a combination of Zhiel Neelsen staining and WHO approved GeneXpert MTB/Rif device for M. tuberculosis and rifampicin resistance, the presence of M. tuberculosis in sputum samples was detected and confirmed. A total of 346 samples were analysed, out of which M. tuberculosis was detected in 91 (26.3%) samples and rifampicin resistance in 6 (6.6%) of the positive samples. HIV prevalence was found to be 46.8%, HIV and TB co-infection 39.6%, while 83.3% of the rifampicin resistance was from HIV positive cases. Tuberculosis was found to be decreasing with increase in CD4 count. Statistically, there was a significant relationship (P 0.05) between gender, occupation and age with TB was observed. Our results show that tuberculosis still remains endemic in Nasarawa state with a high prevalence of HIV and that the confluence of HIV and tuberculosis increased the rate of rifampicin resistance. Provision of Tuberculosis diagnostics with the capacity to detect TB drug resistance beyond rifampicin is highly recommended. VL - 4 IS - 3 ER -
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