Age- and Sex- Related Changes in Pineal Gland: A Morphological and Histological Study
American Journal of Internal Medicine
Volume 3, Issue 6-1, November 2015, Pages: 10-13
Received: May 22, 2015;
Accepted: May 22, 2015;
Published: Oct. 23, 2015
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K G Arunkumar, Department of Anatomy, Government Medical College, Thrissur, India
A Amar Jayanthi, Department of Anatomy, Government Medical College, Thrissur, India
C K Indira, Department of Anatomy, Government Medical College, Thrissur, India
V K Girijamony, Department of Anatomy, Government Medical College, Thrissur, India
Introduction: Pineal gland is believed to be an endocrine gland, melatonin being the principal hormone secreted by it. Updating any knowledge about the anatomy of pineal gland will expand our understanding of pineal physiology and pathophysiology and of the possible medical use of pineal compounds. Materials and Methods: We conducted a cross-sectional observatory study in pineal gland specimens collected from human subjects during autopsy after obtaining written informed consent from relatives. Subjects died of malignancy or head injury were excluded from the study. Morphological and histological analysis was done after preservation. Results: There were 90 adult specimens and 12 fetal specimens. Mean (SD) age, length of specimen, width, thickness (centimeters) and weight (grams) of specimen were 41.37 23.3, 0.79 0.17, 0.59 0.13, 0.35 0.10 and 0.08 0.04 respectively. The average number of pinealocytes and glial cells per field were 184.6 ± 29.41 and 7.20 ± 2.65 respectively. Incomplete lobules were seen in 52 adult specimens and complete in 38. Calcification was observed in 69 specimens. Changes of pattern of lobule from incomplete to complete and increase in calcification were found to be significantly correlated with advancing age. Conclusion: Increasing calcification and change in lobular pattern are observed as advancing age related changes in present study. Estimation of melatonin and data regarding factors affecting these changes may be done further to identify its pathophysiological significance.
K G Arunkumar,
A Amar Jayanthi,
C K Indira,
V K Girijamony,
Age- and Sex- Related Changes in Pineal Gland: A Morphological and Histological Study, American Journal of Internal Medicine. Special Issue: Toxicology.
Vol. 3, No. 6-1,
2015, pp. 10-13.
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