American Journal of Clinical and Experimental Medicine

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Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh

Received: 29 September 2015    Accepted: 15 October 2015    Published: 30 October 2015
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Abstract

Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.

DOI 10.11648/j.ajcem.20150305.20
Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5, September 2015)
Page(s) 255-259
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lipid Profile, Systemic Lupus Erythematosus Disease Activity Index, Dose of Steroid

References
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[2] Silverman E, Eddy A. Systemic Lupus Erythematosus. In: Cassidy JT, Petty RE, Laxer RM, Lindsley CB, editors. Textbook of Paediatric Rheumatology. 6th edition. Philadelphia: Sunders; 2011. P. 315-43
[3] Kakati S, Doley B, Devee A, Dihingia P, Sarma PK. Serum lipid profiles in patients with systemic lupus erythematosus. J Indian Rheumatol Assoc 2003; 11: 5-7.
[4] Toms TE, Panoulas VF, Kitas GD. Dyslipidaemia in Rheumatological Autoimmune Diseases. Open Cardiovasc Med J 2011; 5: 64-75.
[5] Sarkissian T, Beyenne J, Feldman B, Adeli K, Silverman E. The complex nature of the interaction between disease activity and therapy on the lipid profile in patients with pediatric systemic lupus erythematosus. Arthritis & Rheumatism 2006; 54:1283-90.
[6] Sarkissian T, Beyene J, Feldman B, McCrindle B, Silverman ED. Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. Arthritis & Rheum 2007; 56: 613-38.
[7] Thorbinson C, Watson L, Roberts C, Beresford MW, PReS-FINAL-2290: Is an Abnormal Lipid Profile at Diagnosis Related to Increased Disease Activity in JSLE Patients (Poster Presentation). Pediatric Rheumatology 2013; 11 (Suppl2): P 280
[8] Liang MH, Mandl LA, Costenbader K, Fox E, Karlson E. Atherosclerotic Vascular Disease in Systemic Lupus Erythematosus. J Natl Med Assoc 2002; 94: 813-19.
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[14] Siripaitoon B, Osiri M, Vongthavaravat V, Akkasilpa S, Deesomchok U. The prevalence of dyslipoproteinemia in Thai patients with systemic lupus erythematosus. Lupus 2004; 13: 961-8.
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Author Information
  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

  • Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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  • APA Style

    Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. (2015). Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. American Journal of Clinical and Experimental Medicine, 3(5), 255-259. https://doi.org/10.11648/j.ajcem.20150305.20

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    ACS Style

    Mohammad Mofizul Islam; Shahana Akhter Rahman; Mohammad Imnul Islam; Satya Narayan Chaudhary; Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am. J. Clin. Exp. Med. 2015, 3(5), 255-259. doi: 10.11648/j.ajcem.20150305.20

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    AMA Style

    Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am J Clin Exp Med. 2015;3(5):255-259. doi: 10.11648/j.ajcem.20150305.20

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  • @article{10.11648/j.ajcem.20150305.20,
      author = {Mohammad Mofizul Islam and Shahana Akhter Rahman and Mohammad Imnul Islam and Satya Narayan Chaudhary and Mohammad Aminul Islam and Mohammed Mahbubul Islam and Manik Kuma Talukder},
      title = {Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {3},
      number = {5},
      pages = {255-259},
      doi = {10.11648/j.ajcem.20150305.20},
      url = {https://doi.org/10.11648/j.ajcem.20150305.20},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20150305.20},
      abstract = {Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh
    AU  - Mohammad Mofizul Islam
    AU  - Shahana Akhter Rahman
    AU  - Mohammad Imnul Islam
    AU  - Satya Narayan Chaudhary
    AU  - Mohammad Aminul Islam
    AU  - Mohammed Mahbubul Islam
    AU  - Manik Kuma Talukder
    Y1  - 2015/10/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajcem.20150305.20
    DO  - 10.11648/j.ajcem.20150305.20
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 255
    EP  - 259
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20150305.20
    AB  - Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.
    VL  - 3
    IS  - 5
    ER  - 

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