American Journal of Clinical and Experimental Medicine

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The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar

Received: 21 April 2016    Accepted: 03 May 2016    Published: 13 May 2016
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Abstract

Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.

DOI 10.11648/j.ajcem.20160403.16
Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 3, May 2016)
Page(s) 68-75
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Length Sun Exposure, Melasma, Malondialdehyde, MASI Scores

References
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Author Information
  • Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

  • Department of Microbiology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

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    Fadlina Zainuddin, Anis Irawan Anwar, Khairuddin Djawad, Arifin Seweng, Rizalinda Sjahril, et al. (2016). The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. American Journal of Clinical and Experimental Medicine, 4(3), 68-75. https://doi.org/10.11648/j.ajcem.20160403.16

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    ACS Style

    Fadlina Zainuddin; Anis Irawan Anwar; Khairuddin Djawad; Arifin Seweng; Rizalinda Sjahril, et al. The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. Am. J. Clin. Exp. Med. 2016, 4(3), 68-75. doi: 10.11648/j.ajcem.20160403.16

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    AMA Style

    Fadlina Zainuddin, Anis Irawan Anwar, Khairuddin Djawad, Arifin Seweng, Rizalinda Sjahril, et al. The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar. Am J Clin Exp Med. 2016;4(3):68-75. doi: 10.11648/j.ajcem.20160403.16

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  • @article{10.11648/j.ajcem.20160403.16,
      author = {Fadlina Zainuddin and Anis Irawan Anwar and Khairuddin Djawad and Arifin Seweng and Rizalinda Sjahril and Anni Adriani},
      title = {The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {4},
      number = {3},
      pages = {68-75},
      doi = {10.11648/j.ajcem.20160403.16},
      url = {https://doi.org/10.11648/j.ajcem.20160403.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20160403.16},
      abstract = {Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - The Correlation Between Malondialdehyde Serum Levels and the Duration of Sun Exposure; and Melasma Area and Severity Index in Patients with Melasma in Makassar
    AU  - Fadlina Zainuddin
    AU  - Anis Irawan Anwar
    AU  - Khairuddin Djawad
    AU  - Arifin Seweng
    AU  - Rizalinda Sjahril
    AU  - Anni Adriani
    Y1  - 2016/05/13
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ajcem.20160403.16
    DO  - 10.11648/j.ajcem.20160403.16
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 68
    EP  - 75
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20160403.16
    AB  - Ultraviolet (UV) plays an important role in the pathogenesis of melasma. Ultraviolet rays can cause lipid peroxidation in cell membranes that trigger the generation of free radicals that can stimulate melanocytes to produce many melanin. Malondialdehyde (MDA) is the end product of lipid peroxidation in the body. MDA is an important indicator of lipid peroxidation. There are a lot of research has been done in linking MDA to the severity of melasma. But there has not yet any research connecting it with sun exposure in patients with melasma. This study aims to find out the relationship between MDA serum levels and the duration of sun exposure; and Melasma Area and Severity Index (MASI) scores in patients with melasma. The research method was the case control study. It used 84 samples divided into two groups: a melasma group consisting of 42 people and a control group consisting of 42 people. The examination was performed with anamnesis, questionnaires, duration score of sun exposure, physical examination and the assessment of MDA serum levels with Thiobutiric acid-reactive substance test reaction. The data were analysed using independent t test, Mann Whitney, and Spearman correlation test. The results show that there is a significant correlation between the levels of MDA with the duration of sun exposure, but the duration of sun exposure is not associated with MASI score. It means that MDA levels are not significantly associated with MASI scores. Free radicals are significantly associated with the duration of sun exposure, but the severity of melasma is not affected by the duration of sun exposure. The severity level of melasma is still much influenced by some other risk factors associated with the pathogenesis of melasma.
    VL  - 4
    IS  - 3
    ER  - 

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