American Journal of Clinical and Experimental Medicine

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Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients

Received: 07 June 2015    Accepted: 11 May 2016    Published: 03 August 2016
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Abstract

This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.

DOI 10.11648/j.ajcem.20160405.11
Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5, September 2016)
Page(s) 118-121
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Adapalene 0.1% Gel, Clinical Manifestations, Mild Acne Vulgaris, Sebum Levels, Tretinoin 0.05% Gel

References
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[15] Grosshans, E., Marks R., et al. 1998 Evaluation of clinical efficacy and safety of adapalene 0,1% gel versus tretinoin 0,025% gel in the treatment of acne vulgaris, with particular references to the onset of action and impact on quality of life. Br J Dermatol. 139: 26-33.
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Author Information
  • Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Pediatric Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Pharmacy Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

  • Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

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    Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. (2016). Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine, 4(5), 118-121. https://doi.org/10.11648/j.ajcem.20160405.11

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    ACS Style

    Asrawati Sofyan; Farida Tabri; Sri Vitayani Muchtar; Idham Jayaganda; Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am. J. Clin. Exp. Med. 2016, 4(5), 118-121. doi: 10.11648/j.ajcem.20160405.11

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    AMA Style

    Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am J Clin Exp Med. 2016;4(5):118-121. doi: 10.11648/j.ajcem.20160405.11

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  • @article{10.11648/j.ajcem.20160405.11,
      author = {Asrawati Sofyan and Farida Tabri and Sri Vitayani Muchtar and Idham Jayaganda and Gemini Alam and Safruddin Amin and Anis Anwar Irawan},
      title = {Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {4},
      number = {5},
      pages = {118-121},
      doi = {10.11648/j.ajcem.20160405.11},
      url = {https://doi.org/10.11648/j.ajcem.20160405.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20160405.11},
      abstract = {This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.},
     year = {2016}
    }
    

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    T1  - Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients
    AU  - Asrawati Sofyan
    AU  - Farida Tabri
    AU  - Sri Vitayani Muchtar
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    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
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    EP  - 121
    PB  - Science Publishing Group
    SN  - 2330-8133
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    AB  - This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.
    VL  - 4
    IS  - 5
    ER  - 

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