Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 6, November 2016, Pages: 170-178
Received: Sep. 16, 2016; Accepted: Sep. 28, 2016; Published: Nov. 10, 2016
Views 2626      Downloads 53
Authors
Nurhayati Edison, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Safruddin Amin, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Khairuddin Djawad, Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Raden Satriono, Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Department of Pediatric, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Yohanes Widodo, Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia
Marianti A. Manggau, Department of Pharmacy, Hasanuddin University, Makassar, Indonesia
Article Tools
Follow on us
Abstract
Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher’s exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).
Keywords
Moderate to Severe Acne Vulgaris, Autologous Serum, Estradiol
To cite this article
Nurhayati Edison, Safruddin Amin, Khairuddin Djawad, Raden Satriono, Yohanes Widodo, Marianti A. Manggau, Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 6, 2016, pp. 170-178. doi: 10.11648/j.ajcem.20160406.13
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Anwar, A. I, Tata Laksana Akne Vulgaris Makassar. Dua Satu Pree, 2013.
[2]
Bowe, W. P. & Shalita, A. R, Introduction: Epidemiology, Cost, And Psychosocial Implications. In: Shalita, A. R., Rosso, J. Q. D. & Webster, G. F. (Eds.) Acne Vulgaris. New York: Informa Healhcare. 2011.
[3]
Zaenglein, A. L., Graber, E. M. & Thiboutot, D. M, Acne Vulgaris And Acneiform Eruptions. In: Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J. & Wolff, K. (Eds.) Fitzpatrick's Dermatology In General Medicine. 8 Th Ed. New York: Mc Graw Hill. 2012.
[4]
James, W. D., Berger, T. G. & Elston, D. M, Andrews' Diseases Of The Skin Clinical Dermatology "Acne" Philadelphia, Saudres Elsevier. 2006.
[5]
Tahir, C. M, Pathogenesis Of Acne Vulgaris: Simplified. J Pakistan Association Of Dermatologists, 2010. 20: p. 93-7
[6]
George, R., Clarke, S. & Thiboutot, D, Hormonal Therapy For Acne. Semin Cutan Med Surg, 2008: 27: p. 188-96
[7]
Knor, T, The Pathogenesis Of Acne. Acta Dermatovenerol Croat, 2005. 13: p. 44-9.
[8]
Balachandrudu, B., Niveditadevi, V. & Rani, T. P, Hormon Pathogenesis Of Acne- Simplified. Inter J Scient Study, 2015. 3: p. 183-185.
[9]
Shaw, J. C, Acne Efffect Of Hormones On Pathogenesis And Management. Am J Clin Dermatol, 2002. 3: p. 571-578.
[10]
Hanafiah, M. J, Haid Dan Siklusnya, In: Wiknjosastro, H., Saifuddin, A. B. & Rachimhadhi, T. (Eds.) Ilmu Kandungan Tridasa Printer, Jakarta: Yayasan Bima Pustaka Sarwono Prawirohardji. 2007.
[11]
Jacoeb, T. Z, Endokrinologi Reproduksi Pada Wanita, In: Wiknjosastro, H., Saifuddin, A. B. & Rachimhadhi, T. (Eds.) Ilmu Kandungan Tridasa Printer, Jakarta: Yayasan Bima Pustaka Sarwono Prawirohardji. 2007.
[12]
Gruber, C. J., Tschugguel, W., Schneeberger, C. & Huber, J. C, Production And Actions Of Estrogens. N Engl J Med, 2002. 346: p. 340-52.
[13]
Thiboutot, D. & Chen, W, Update And Future Of Hormonal Therapy. Dermatol, 2003. 206: p. 57-67.
[14]
Ebede, T. L., Arch, E. L. & Berson, D, Hormonal Treatment Of Acne In Women. J Clin Aesthetic Dermatol, 2009. 12: p. 16-22.
[15]
Lakshmi, C, Hormone Therapy In Acne. Ind J Dermatol-Venereo And Lepro, 2013. 79: p. 322-36.
[16]
Baumann, M, Acne. In: Bauman L & Wwisberg E (Eds). Cosmetic dermatology principles and practice. New York, The McGraw-Hill Companies. 2002.
[17]
Gollnick, H. & Cunliffe, W, Management Of Acne A Report From A Global Alliance To Improve. Jaad, 2003. 49: p. S1-5.
[18]
Preneau S, Dreno B, Female acne – a different subtype of teenager acne? JEADV, 2011. 26: p. 277-82.
[19]
Harper, J. C, Hormonal Therapy For Acne Using Oral Contraceptive Pills. Semin Cutan Med Surg, 2005. 24: p. 103-106.
[20]
Geerling, G., MacLennan, S., Hartwig, D, Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol, 2004. 88: p. 1467-74.
[21]
Poon, A. C., Geerling, G., Dart, J. K., Fraenkel, G. E., Daniels, J. T, Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. Br J Ophthalmol, 2001. 85 (10): p. 1188-97.
[22]
Ilham, Pengujian tetes mata serum autolog sebagai antibakteri dan inflamasi pada penyakit permukaan okuler. Makassar, Universitas Hasanuddin. 2011.
[23]
Tsubota, K., Goto, E., Fujita, H., Ono, M., Inoue, H., Saito, I., et al, Treatment of dry eye by autlogous serum application in Sjogren's syndrome. Br J Dermatol, 1999. 83: p. 390-5.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186