Cancer Antigen (CA-125) is a tumor marker used to detect ovarian cancer. This study aims to determine the relationship of VEGF expression and the levels of CA-125 on primary tumor associated with stage, degree of differentiation and histopathological types of epithelial ovarian cancer. This study is an observational study with a cross sectional design in Wahidin Sudirohusodo Hospital and some parts teaching hospital of Obstetrics and Gynecology began in August 2015 to February 2016. The population was all patients with epithelial ovarian cancer who were treated and underwent surgery at the hospital who met the inclusion criteria. The data were processed using SPSS with bivariate analysis Mann Whitney, Kruskal Wallis and Spearman's Rho. The result there were significant differences of VEGF expression in cell differentiation and histopathological type (p <0.05). There are significant differences in the levels of CA-125 with clinical stage, differentiation of cells and histopathological type (p <0.05). The expression of VEGF is getting stronger when the type of epithelial ovarian cancer is getting bad influence on the degree of cells differentiation and the histopathological type. CA-125 levels obtained increased at an advanced stage and degree of cells differentiation are bad for ovarian cancer. There is a positive correlation between the expression of VEGF and CA-125 levels in epithelial ovarian cancer but was not significantly different and the relationship is weak.
| Published in | Journal of Gynecology and Obstetrics (Volume 4, Issue 6) |
| DOI | 10.11648/j.jgo.20160406.16 |
| Page(s) | 62-67 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
VEGF, CA-125, Epithelial Ovarian Cancer
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APA Style
Farid Abdullah, Syahrul Rauf, Nusratuddin Abdullah, Maisuri T. Chalid, Deviana S. Riu, et al. (2017). Correlation Between Expressions of VEGF and CA-125 with Stage, Level of Differentiation and Histopathology Type of Epithelial Ovarian Cancer. Journal of Gynecology and Obstetrics, 4(6), 62-67. https://doi.org/10.11648/j.jgo.20160406.16
ACS Style
Farid Abdullah; Syahrul Rauf; Nusratuddin Abdullah; Maisuri T. Chalid; Deviana S. Riu, et al. Correlation Between Expressions of VEGF and CA-125 with Stage, Level of Differentiation and Histopathology Type of Epithelial Ovarian Cancer. J. Gynecol. Obstet. 2017, 4(6), 62-67. doi: 10.11648/j.jgo.20160406.16
AMA Style
Farid Abdullah, Syahrul Rauf, Nusratuddin Abdullah, Maisuri T. Chalid, Deviana S. Riu, et al. Correlation Between Expressions of VEGF and CA-125 with Stage, Level of Differentiation and Histopathology Type of Epithelial Ovarian Cancer. J Gynecol Obstet. 2017;4(6):62-67. doi: 10.11648/j.jgo.20160406.16
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Download@article{10.11648/j.jgo.20160406.16,
author = {Farid Abdullah and Syahrul Rauf and Nusratuddin Abdullah and Maisuri T. Chalid and Deviana S. Riu and Upik A. Miskad},
title = {Correlation Between Expressions of VEGF and CA-125 with Stage, Level of Differentiation and Histopathology Type of Epithelial Ovarian Cancer},
journal = {Journal of Gynecology and Obstetrics},
volume = {4},
number = {6},
pages = {62-67},
doi = {10.11648/j.jgo.20160406.16},
url = {https://doi.org/10.11648/j.jgo.20160406.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20160406.16},
abstract = {Cancer Antigen (CA-125) is a tumor marker used to detect ovarian cancer. This study aims to determine the relationship of VEGF expression and the levels of CA-125 on primary tumor associated with stage, degree of differentiation and histopathological types of epithelial ovarian cancer. This study is an observational study with a cross sectional design in Wahidin Sudirohusodo Hospital and some parts teaching hospital of Obstetrics and Gynecology began in August 2015 to February 2016. The population was all patients with epithelial ovarian cancer who were treated and underwent surgery at the hospital who met the inclusion criteria. The data were processed using SPSS with bivariate analysis Mann Whitney, Kruskal Wallis and Spearman's Rho. The result there were significant differences of VEGF expression in cell differentiation and histopathological type (p <0.05). There are significant differences in the levels of CA-125 with clinical stage, differentiation of cells and histopathological type (p <0.05). The expression of VEGF is getting stronger when the type of epithelial ovarian cancer is getting bad influence on the degree of cells differentiation and the histopathological type. CA-125 levels obtained increased at an advanced stage and degree of cells differentiation are bad for ovarian cancer. There is a positive correlation between the expression of VEGF and CA-125 levels in epithelial ovarian cancer but was not significantly different and the relationship is weak.},
year = {2017}
}
TY - JOUR T1 - Correlation Between Expressions of VEGF and CA-125 with Stage, Level of Differentiation and Histopathology Type of Epithelial Ovarian Cancer AU - Farid Abdullah AU - Syahrul Rauf AU - Nusratuddin Abdullah AU - Maisuri T. Chalid AU - Deviana S. Riu AU - Upik A. Miskad Y1 - 2017/01/10 PY - 2017 N1 - https://doi.org/10.11648/j.jgo.20160406.16 DO - 10.11648/j.jgo.20160406.16 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 62 EP - 67 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20160406.16 AB - Cancer Antigen (CA-125) is a tumor marker used to detect ovarian cancer. This study aims to determine the relationship of VEGF expression and the levels of CA-125 on primary tumor associated with stage, degree of differentiation and histopathological types of epithelial ovarian cancer. This study is an observational study with a cross sectional design in Wahidin Sudirohusodo Hospital and some parts teaching hospital of Obstetrics and Gynecology began in August 2015 to February 2016. The population was all patients with epithelial ovarian cancer who were treated and underwent surgery at the hospital who met the inclusion criteria. The data were processed using SPSS with bivariate analysis Mann Whitney, Kruskal Wallis and Spearman's Rho. The result there were significant differences of VEGF expression in cell differentiation and histopathological type (p <0.05). There are significant differences in the levels of CA-125 with clinical stage, differentiation of cells and histopathological type (p <0.05). The expression of VEGF is getting stronger when the type of epithelial ovarian cancer is getting bad influence on the degree of cells differentiation and the histopathological type. CA-125 levels obtained increased at an advanced stage and degree of cells differentiation are bad for ovarian cancer. There is a positive correlation between the expression of VEGF and CA-125 levels in epithelial ovarian cancer but was not significantly different and the relationship is weak. VL - 4 IS - 6 ER -
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