Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.
| Published in | Journal of Diseases and Medicinal Plants (Volume 3, Issue 1) |
| DOI | 10.11648/j.jdmp.20170301.12 |
| Page(s) | 7-11 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Aortic Tissue, Blood Pressure, Cardiovascular Diseases, Effect, Extract, Guinea Pigs, Hypertension, P. Guava
| [1] | Barbalho S. M., Farinazzi-Machado F. M. V., GoulartR. A., Brunnati A. C. S., Ottoboni A. M. M. B. and Nicolau C. C. T. (2012). Review on Psidium Guajava (Guava): A Plant of Multipurpose Medicinal ApplicationsMedAromat Plants; 1 (4): 1-6. |
| [2] | Beatriz P., Ezequiel V., Azucena O. and Pilar C. (2012). Antifungal activity of Psidium guajavaorganic extracts against dermatophytic fungi. Journal of Medicinal Plants Research; 6 (41): 5435-5438. |
| [3] | Belayneh A., Asfa Z., Demissew S. and Bussa F. (2012). Medicinal plants potential and use by pastoraland agro-pastoral communities in Erer Valley of BabileWereda, Eastern Ethiopia. Journal of Ethnobiology and Ethnomedicine; 8 (42). |
| [4] | Claudia I. Gamboa-Gómez, Nuria E. Rocha-Guzmán, J. Alberto Gallegos-Infante, Martha R. Moreno-Jiménez, Blanca D. Vázquez-Cabral, Rubén F. González-Laredo (2015). Plants with potential use on obesity and its complications. EXCLI Journal; 14: 809-831. |
| [5] | Crews C., Plantinga C., Miller III R., Saran R., Hedgeman E., Saydah H., Williams E. and Powe R. (2010). Prevalence of Chronic Kidney Disease in Persons with Undiagnosed or Pre-Hypertension in the U. S. Hypertension; 55 (5): 1102–1109. |
| [6] | DuttaS. and Das S. (2010). A study of the anti-inflammatory effect of the leaves of Psidium guajava Linn; on experimental animal models. Pharmacognosy Res.; 2 (5): 313–317. |
| [7] | Ekaluo U., Erem F., Omeje I., Ikpeme E., IbiangY. andEkanem B. (2013). Is aqueous leaf extract of guava spermatotoxic in rat? Journal of Environmental Science, Toxicology and Food Technology; 3: 21-23. |
| [8] | Ezekwesili O., Nkemdilim U. and Okeke U. (2010). Mechanism of antidiarrhoeal effect of ethanolic extract of Psidium guajavaleaves. Biokemistry; 22 (2): 2-6. |
| [9] | Fanta G., Anteneh B., Tsige G-M. (2010). Evaluation of Antimicrobial and Anti-inflammatory Activities and Formulation Studies on the Leaf Extracts of Psidium gaujava L. Ethiop. Pharm. J. 28, 1. |
| [10] | Gaurav C., Mustafa F. L. and Mohammad A. (2012). Altered Functioning of Both Renal Dopamine D1 and Angiotensin II Type 1 Receptors Causes Hypertension in Old Rats. Hypertension; 59 (5): 1029–1036. |
| [11] | Ghayur M. and Gilani A. (2005). Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Cardiovascular Pharmacology; 45: 74-80. |
| [12] | Gilani H., Mandukhail S., Iqbal J., Yasinzai M., Aziz N., Khan A., Rehman N. (2010). Antispasmodic and vasodilator activities of Morindacitrifoliaroot extract are mediated through blockade of voltage dependent calcium channels. BMC; 10 (2): 1472-6882. |
| [13] | Hall E., da Silva A., da Carmo M., Dubinion J., Hamza S., Munusamy S., Smith G., and Stec E. (2010). Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins. JBiol Chemistry; 285 (23): 17271–17276. |
| [14] | Hassan R. (2012). Medicinal Plants (Importance and Uses). Pharmaceut Anal Acta 3: 10. |
| [15] | Hendriks E., Wit M., Roos L., Brewster M., Akande M., de Beer H., Mfinanga G., Kahwa M., Gatongi P., Rooy V., Janssens W., Lammers J., Kramer B., Bonfrer I., Gaeb E., der Gaag J., de Wit R., Lange J., and Schultsz C. (2012). Hypertension in Sub-Saharan Africa: Cross-Sectional Surveys in Four Rural and Urban Communities. Hypertension in Sub-Saharan Africa; 7: 5-16. |
| [16] | Joseph B. and Priya R. (2011). Review on Nutritional, Medicinal and Pharmacological Properties of Psidium guava. International Journal of Pharma and Biosciences; 2: 53-69. |
| [17] | Jun N., Mosaddik A., Moon Y., Jang K., Lee D., Ahn S. and Cho K. (2011). Cytotoxic Activity of Caryophyllene Oxide Isolated from Jeju Guava (Psidium cattleianumSabine) Leaf. Rec. Nat. Prod.; 5 (3): 242-246. |
| [18] | Khan R. T., Stewart C. P., Christian P., Schulze K., WuL. LeClerq S. C., KhatryS. K. and West K. P. (2013). A cross-sectional study of the prevalence and risk factors for hypertension in rural Nepali women. BMC Public Health, 13 (55):1472-2458. |
| [19] | Kumar A. (2012). Importance for life of Psidium guava. International Journal of Research in Pharmaceutical and Biomedical Sciences; 3 (1):137-140. |
| [20] | Kumar R., KandagatlaK. Andchillal S. (2011). Signature on medicinal plants used in hypertension. International Journal of Pharmacy&Technology; 3 (3):1333-1355. |
| [21] | Lakshmi T., Roy A., Durgha K. and ManjushaV. (2013). Coping With Hypertension Using Safer Herbal Medicine. International Journal of Drug Development and Research; 3 (3): 12-19. |
| [22] | Larson A. J., Symons J. D. and Jalili T. (2010). Quercetin: A Treatment for Hypertension?—A Review of Efficacy and Mechanisms. Pharmaceuticals; 3: 237-250 |
| [23] | Matthew C., Yoon S., Ortiz E., Wall K., Schober S., Gillespie C., Sorlie P., Keenan N., Labarthe D. And Hong Y. (2012). National surveillancedefinitions for hypertension prevalence and control among adults. CircCardiovascQual Outcomes; 5 (3): 343–351. |
| [24] | Mekoya. (2007). Hypotensive Effects of Aqueous Extract of Moringastenopetala in both in vivoand in vitro Animal Models. Thesis for fulfillment of master degree in Physiology, Addis Ababa University; pp: 14-50. |
| [25] | Mohd D. S., Khaizil E. Z and Norliza A. (2012). Screening on anti-proliferative activity of Psidium guajavaleaves extract towards selected cancer celllines. Journal of US-China Medical Science; 9 (86): 30–37. |
| [26] | Nahida and Feroz, (2011). Role of natural herbs in the treatment of hypertension. National Cholesterol Education Program Nationa; National Institutes of Health NIH No. 02, pp 20-39. |
| [27] | Nwokocha R., Owu U., Gordon A., Thaxter K., McCalla G., Ozolua I. and Young L. (2012). Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague Dawley rats. Pharmaceutical Biology; 50 (11): 1436 |
| [28] | Osman M., Ahmed M., Mahfouz S. and Elaby S. (2011). Biochemical studies on the hepatoprotective effects of pomegranate and guava ethanol extracts. New York Science Journal; 4 (3): 31-38. |
| [29] | Robitaille C., Dai S., S. C, Loukine L., Bancej C., Quach S., Ellison J., Campbell N., Karen T., ReimerK., Walker R., Smith M., Blais C. and Quan H. (2012). Diagnosed hypertension in Canada: incidence, prevalence and associated mortality, CMAJ; 184 (1): 49–56. |
| [30] | Saleh Hosseinzadeh, AzizollahJafarikukhdan, Ahmadreza Hosseini, Raham Armand (2015), The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris. International Journal of Clinical Medicine; 6: 635-642. |
| [31] | Sanda A., Grema A., Geidam A. and Bukar-KoloM. (2011). Pharmacological aspects of Psidium guajava. Journal of Pharmacology; 7: 316-324. |
| [32] | Sandhar K., Kumar B., Prasher S., Tiwari P., Salhan M., Sharma P. (2011). A Review of Phytochemistry and Pharmacology of Flavonoids. International Pharmaceutical Science; 1: 25-35. |
| [33] | S. B. Padal, N. Mary Roja, S. Devi Soundarya, (2015). A Review on Ethnomedicinal Plants Used For Antidiabetic Medicine in Andhra Pradesh. Advances in Biology and BioMedicine; 2 (1): 1-7. |
| [34] | Singh R. (2015). A review on Medicinal plants. Journal of Plant Sciences; 3 (1-1): 50-55. |
| [35] | Shakeera B., Sujatha K, Sridharan G. and Manikandan R. (2013) Antihyperglycemic and antihyperlipidemic potentials of Psidium guajava in alloxan-induced diabetic rats. Asian J Pharm Clin Res; 6 (2):88-89. |
| [36] | Sharma, K., Vyawahare, S. andLadhha A. (2010). Preclinical screening model for hypertension in rodents. Pharmacology Online; 3: 458-472. |
| [37] | Shinde S., Chivate N., Kulkarni P. and Naikwade N. (2013). Hypolipidemic Activity of Psidiumguajava Linn Leaves Extracts in Hyperlipidemic Rats International Journal of Pharmacy and Pharmaceutical Sciences; 5 (1): 1-3. |
| [38] | Shruthi D., Roshan A., TimilsinaS. andSunita S.(2013). Review on the Medicinal Plant Psidium guajavaLinn. (Myrtaceae). Journal of Drug Delivery & Therapeutics; 3 (2): 162-168. |
| [39] | ThamizhSelvam N, Surabhi Kr and Swami Gk (2015). A review on Ethno medicinal value of hibiscus hispidissimus International Journal of Current Science and Technolog; 3 (6): 28-31. |
| [40] | Vanitha R. P., Sahana N, and Asna U. (2012). Anti-oxidant activity of Aegle, Marmelons and Psidium guava. Int. J. Med. Arom. Plants; 2 (1): 155-160. |
| [41] | Weni L. (2011). Anti-Inflammatory Activity of The Extract of Guava Leaves (Psidium guajava L.) in the rats (Rattusnorvegicus L.). Indonesian Journal of Cancer Chemoprevention; 2 (1): 169-172. |
| [42] | World Health Organization (WHO). (2010). Global status report on non-communicable diseases. |
APA Style
Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. (2017). The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. Journal of Diseases and Medicinal Plants, 3(1), 7-11. https://doi.org/10.11648/j.jdmp.20170301.12
ACS Style
Abayneh Elias; Daniel Seifu; Frank Ashall; Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J. Dis. Med. Plants 2017, 3(1), 7-11. doi: 10.11648/j.jdmp.20170301.12
AMA Style
Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J Dis Med Plants. 2017;3(1):7-11. doi: 10.11648/j.jdmp.20170301.12
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Download@article{10.11648/j.jdmp.20170301.12,
author = {Abayneh Elias and Daniel Seifu and Frank Ashall and Tesfaye Tolessa},
title = {The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs},
journal = {Journal of Diseases and Medicinal Plants},
volume = {3},
number = {1},
pages = {7-11},
doi = {10.11648/j.jdmp.20170301.12},
url = {https://doi.org/10.11648/j.jdmp.20170301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170301.12},
abstract = {Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.},
year = {2017}
}
TY - JOUR T1 - The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs AU - Abayneh Elias AU - Daniel Seifu AU - Frank Ashall AU - Tesfaye Tolessa Y1 - 2017/02/16 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20170301.12 DO - 10.11648/j.jdmp.20170301.12 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 7 EP - 11 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20170301.12 AB - Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals. VL - 3 IS - 1 ER -
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