Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon
International Journal of Pharmacy and Chemistry
Volume 2, Issue 2, November 2016, Pages: 15-19
Received: Sep. 17, 2016; Accepted: Oct. 12, 2016; Published: Oct. 21, 2016
Views 3498      Downloads 189
Author
Omar H. Al-Obaidi, Chemistry Department, Education College for Girls, Al-Anbar University, Ramadi, Iraq
Article Tools
Follow on us
Abstract
A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.
Keywords
Flavone, Metal Complexes, Synthesis, Spectral, Theoretical Evaluation
To cite this article
Omar H. Al-Obaidi, Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon, International Journal of Pharmacy and Chemistry. Vol. 2, No. 2, 2016, pp. 15-19. doi: 10.11648/j.ijpc.20160202.12
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Hertog, M. G. L.; Feskens, E. J.; Hollman, P. C.; Katan, M. B.; Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993, 342, 1007-1011.
[2]
Knekt, P.; Kumpulainen, J.; Jarvinen, R.; Rissanen, H.; Heliovaara, M.; Reunanen, A.; Hakulinen, T.; Aromaa, A. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 2002, 76,560-568.
[3]
Cushnie, T.; Lamb, A. Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents, 2005, 26,343-356. And Maria M. Kasprzak, Andrea Erxleben and Justyn Ochocki, “Properties and applications of flavonoid metal complexes,” Review Article 2015. DOI: 10.1039/C5RA05069C
[4]
Ferguson, P. J.; Kurowska, E. M.; Freeman, D. J. In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract. Nutr. Cancer 2006, 56, 86-94.
[5]
Jovanovic, S. V.; Steenken, S.; Simic, M. G.; Hara, Y.; Antioxidant properties of flavonoids: Reduction potentials and electron transfer reactions of flavonoid radicals. In Flavonoids in Health and Disease; Rice-Evans, C. A., Packer, L., Eds.; Marcel Dekker, Inc.: New York, NY, 1998; pp. 137-161.
[6]
Teixeira S.; Siquet, C.; Aloes, C.; Boal, I.; Marques, M. P.; Borges, F.; Lima, J. L. F. C.; Reis, S. Structure-property studies on the antioxidant activity of flavonoids present in diet. Free Radic. Biol. Med. 2005, 39, 1099-1108.
[7]
Pietta, P. G. Flavonoids as Antioxidants. J. Nat. Prod. 2000, 63, 1035-1042. And Yuanzhen Liu 1 and Mingquan Guo,” Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry”, Molecules 2015, 20, 8583-8594; doi:10.3390/molecules20058583.
[8]
Van Acker, S. A. B. E.; van Den Berg, D.-J.; Tromp, M. N. J. L.; Griffioen, D. H.; van Bennekom, W. P.; van der Vijgh, W. J. F.; Bast, A. Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med. 1996, 20, 331-342.
[9]
van Acker, S. A. B.; van Balen, G. P.; van den Berg, D. J.; Bast, A.; van der Vijgh, W.F.F. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem. Pharmacol. 1998, 56, 935-943.
[10]
Grazul, M.; Budzisz, E. Biological activity of metal ions complexes of chromones, coumarins and flavones. Coord. Chem. Rev. 2009, 253, 2588–2598.
[11]
Cazarolli, L. H.; Zanatta, L.; Jorge, A. P.; de Sousa, E.; Horst, H.; Woehl, V. M.; Pizzolatti, M. G.; Szpoganicz, B.; Silva, F. R. M. B. Follow-up studies on glycosylated flavonoids and their complexes with vanadium: Their anti- hyperglycemic potential role in diabetes. Chemico-Biol. Interact. 2006, 163, 177–191.
[12]
Pereira, R. M. S.; Andrades, N. E. D.; Paulino, N.; Sawaya, A. C. H. F.; Eberlin, M. N.; Marcucci M.C.; Favero, G. M.; Novak, E. M.; Bydlowski, S. P. Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity, Molecules 2007, 12, 1352-1366.
[13]
Jun, T.; Bochu, W.; Liancai, Z. Hydrolytic cleavage of DNA by quercetin zinc (II) complex. Bioorg. Med. Chem. Lett. 2007, 17, 1197-1199.
[14]
Lever, A. B. P. Inorganic Electronic Spectroscopy; Elsevier: Amsterdam, the Netherlands, 1986; pp. 385–392.
[15]
K. Nakmato, Infarred and Raman spectra of Inorganic and coordination compounds, 4th ed., Wiley, New York (1986). Omar H. Al-Obaidi.,” Synthesis, Spectral Characterization, Theoretical Evaluation Of New Cr (III), Co (II), Fe(III) And Cu(II) Complexes”, App. Sci. Report.,12 (1), 2015: 41-45
[16]
Malesev, D., Kuntic, V. Investigation of metal-flavonoid chelates and determination of flavonoids via metal-flavonoid complexing reactions. J. Serb. Chem. Soc. 2007, 72, pp 921-939.
[17]
Job, P. Recherches sur la formation de complexes mineraux en solution, et sur leur stabilite (in Paris). Ann. Chim. 1928, 9, pp 113-203.
[18]
Irving H. and Williams R. S. P., J. Chem. Soc., 3192 (1953).
[19]
Birt, F. D, Hendrich, S, Wang, W., “Dietary Agents in Cancer Prevention Flavonoids and Isoflavonoids Pharmacology and Therapeutics”, USA, pp 157-177, 2001.
[20]
Ikeda NE, Novak EM, Maria DA, Velosa AS, Pereira RM. “Synthesis, characterization and biological evaluation of Rutin-zinc(II) flavonoid -metal complex,” Chem Biol Interact. 2015. 5; 239: 184-91.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186