Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage

Luca Masotti; Mario Di Napoli; Daniel Agustin Godoy; Grazia Panigada; Stefano Spolveri; Gianni Lorenzini; Giancarlo Landini

doi:doi:10.11648/j.ijcems.20150102.13

Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage

Luca Masotti, Mario Di Napoli, Daniel Agustin Godoy, Grazia Panigada, Stefano Spolveri, Gianni Lorenzini, Giancarlo Landini

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 2)

Received: 7 June 2015 Accepted: 24 June 2015 Published: 25 June 2015

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Abstract

Venous thromboembolism (VTE), encompassing for deep vein thrombosis (DVT) and pulmonary embolism (PE), represents the most feared complication in patients suffering from spontaneous intracerebral hemorrhage (ICH). The balance between VTE risk and the risk of hematoma expansion and/or re-bleeding is the cornerstone of prophylaxis which is based on non-pharmacological and pharmacological strategies. In the latest years results of three randomized clinical trials on non-pharmacological prophylaxis in ischemic and hemorrhagic stroke have been published. Intermittent pneumatic compression has shown to be effective in ICH compared to placebo, whereas graduated compression stockings failed to show their superiority over placebo. Few and low quality studies reported on pharmacological prophylaxis in ICH. Overall, these studies showed that pharmacological prophylaxis could be safe, but whether it is more effective than other non-pharmacological methods remains unclear. A meta-analysis of four randomized controlled studies showed that pharmacological prophylaxis significantly reduces the rate of pulmonary embolism. Consequently, recommendations from Scientific Societies for VTE prevention in ICH are based on weak literature evidence. In the present article, the Authors provide a review on VTE prevention in ICH and propose a practical algorithm for clinical management of this topic.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 2)
DOI	10.11648/j.ijcems.20150102.13
Page(s)	16-21
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Venous Thromboembolism, Prophylaxis, Intracerebral Hemorrhage

References

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APA Style

Luca Masotti, Mario Di Napoli, Daniel Agustin Godoy, Grazia Panigada, Stefano Spolveri, et al. (2015). Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. International Journal of Clinical and Experimental Medical Sciences, 1(2), 16-21. https://doi.org/10.11648/j.ijcems.20150102.13

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ACS Style

Luca Masotti; Mario Di Napoli; Daniel Agustin Godoy; Grazia Panigada; Stefano Spolveri, et al. Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. Int. J. Clin. Exp. Med. Sci. 2015, 1(2), 16-21. doi: 10.11648/j.ijcems.20150102.13

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AMA Style

Luca Masotti, Mario Di Napoli, Daniel Agustin Godoy, Grazia Panigada, Stefano Spolveri, et al. Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. Int J Clin Exp Med Sci. 2015;1(2):16-21. doi: 10.11648/j.ijcems.20150102.13

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@article{10.11648/j.ijcems.20150102.13,
  author = {Luca Masotti and Mario Di Napoli and Daniel Agustin Godoy and Grazia Panigada and Stefano Spolveri and Gianni Lorenzini and Giancarlo Landini},
  title = {Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {1},
  number = {2},
  pages = {16-21},
  doi = {10.11648/j.ijcems.20150102.13},
  url = {https://doi.org/10.11648/j.ijcems.20150102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150102.13},
  abstract = {Venous thromboembolism (VTE), encompassing for deep vein thrombosis (DVT) and pulmonary embolism (PE), represents the most feared complication in patients suffering from spontaneous intracerebral hemorrhage (ICH). The balance between VTE risk and the risk of hematoma expansion and/or re-bleeding is the cornerstone of prophylaxis which is based on non-pharmacological and pharmacological strategies. In the latest years results of three randomized clinical trials on non-pharmacological prophylaxis in ischemic and hemorrhagic stroke have been published. Intermittent pneumatic compression has shown to be effective in ICH compared to placebo, whereas graduated compression stockings failed to show their superiority over placebo. Few and low quality studies reported on pharmacological prophylaxis in ICH. Overall, these studies showed that pharmacological prophylaxis could be safe, but whether it is more effective than other non-pharmacological methods remains unclear. A meta-analysis of four randomized controlled studies showed that pharmacological prophylaxis significantly reduces the rate of pulmonary embolism. Consequently, recommendations from Scientific Societies for VTE prevention in ICH are based on weak literature evidence. In the present article, the Authors provide a review on VTE prevention in ICH and propose a practical algorithm for clinical management of this topic.},
 year = {2015}
}

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TY  - JOUR
T1  - Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage
AU  - Luca Masotti
AU  - Mario Di Napoli
AU  - Daniel Agustin Godoy
AU  - Grazia Panigada
AU  - Stefano Spolveri
AU  - Gianni Lorenzini
AU  - Giancarlo Landini
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ijcems.20150102.13
DO  - 10.11648/j.ijcems.20150102.13
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 16
EP  - 21
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20150102.13
AB  - Venous thromboembolism (VTE), encompassing for deep vein thrombosis (DVT) and pulmonary embolism (PE), represents the most feared complication in patients suffering from spontaneous intracerebral hemorrhage (ICH). The balance between VTE risk and the risk of hematoma expansion and/or re-bleeding is the cornerstone of prophylaxis which is based on non-pharmacological and pharmacological strategies. In the latest years results of three randomized clinical trials on non-pharmacological prophylaxis in ischemic and hemorrhagic stroke have been published. Intermittent pneumatic compression has shown to be effective in ICH compared to placebo, whereas graduated compression stockings failed to show their superiority over placebo. Few and low quality studies reported on pharmacological prophylaxis in ICH. Overall, these studies showed that pharmacological prophylaxis could be safe, but whether it is more effective than other non-pharmacological methods remains unclear. A meta-analysis of four randomized controlled studies showed that pharmacological prophylaxis significantly reduces the rate of pulmonary embolism. Consequently, recommendations from Scientific Societies for VTE prevention in ICH are based on weak literature evidence. In the present article, the Authors provide a review on VTE prevention in ICH and propose a practical algorithm for clinical management of this topic.
VL  - 1
IS  - 2
ER  -

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Author Information

Luca Masotti

Internal Medicine, Santa Maria Nuova Hospital, Florence, Italy
Mario Di Napoli

Neurological Service, San Camillo de’ Lellis Hospital, Rieti, Italy
Daniel Agustin Godoy

Neurointensive Care Unit, Sanatorio Pasteur and Intensive Care Unit, Hospital San Juan Bautista, Catamarca, Argentina
Grazia Panigada

Internal Medicine, SS Damiano and Cosma Hospital, Pescia, Italy
Stefano Spolveri

Internal Medicine, Borgo San Lorenzo Hospital, Florence, Italy
Gianni Lorenzini

Emergency Medicine, Pontedera Hospital, Pisa, Italy
Giancarlo Landini

Internal Medicine, Borgo San Lorenzo Hospital, Florence, Italy

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APA Style

Luca Masotti, Mario Di Napoli, Daniel Agustin Godoy, Grazia Panigada, Stefano Spolveri, et al. (2015). Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. International Journal of Clinical and Experimental Medical Sciences, 1(2), 16-21. https://doi.org/10.11648/j.ijcems.20150102.13

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ACS Style

Luca Masotti; Mario Di Napoli; Daniel Agustin Godoy; Grazia Panigada; Stefano Spolveri, et al. Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. Int. J. Clin. Exp. Med. Sci. 2015, 1(2), 16-21. doi: 10.11648/j.ijcems.20150102.13

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AMA Style

Luca Masotti, Mario Di Napoli, Daniel Agustin Godoy, Grazia Panigada, Stefano Spolveri, et al. Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage. Int J Clin Exp Med Sci. 2015;1(2):16-21. doi: 10.11648/j.ijcems.20150102.13

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@article{10.11648/j.ijcems.20150102.13,
  author = {Luca Masotti and Mario Di Napoli and Daniel Agustin Godoy and Grazia Panigada and Stefano Spolveri and Gianni Lorenzini and Giancarlo Landini},
  title = {Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {1},
  number = {2},
  pages = {16-21},
  doi = {10.11648/j.ijcems.20150102.13},
  url = {https://doi.org/10.11648/j.ijcems.20150102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150102.13},
  abstract = {Venous thromboembolism (VTE), encompassing for deep vein thrombosis (DVT) and pulmonary embolism (PE), represents the most feared complication in patients suffering from spontaneous intracerebral hemorrhage (ICH). The balance between VTE risk and the risk of hematoma expansion and/or re-bleeding is the cornerstone of prophylaxis which is based on non-pharmacological and pharmacological strategies. In the latest years results of three randomized clinical trials on non-pharmacological prophylaxis in ischemic and hemorrhagic stroke have been published. Intermittent pneumatic compression has shown to be effective in ICH compared to placebo, whereas graduated compression stockings failed to show their superiority over placebo. Few and low quality studies reported on pharmacological prophylaxis in ICH. Overall, these studies showed that pharmacological prophylaxis could be safe, but whether it is more effective than other non-pharmacological methods remains unclear. A meta-analysis of four randomized controlled studies showed that pharmacological prophylaxis significantly reduces the rate of pulmonary embolism. Consequently, recommendations from Scientific Societies for VTE prevention in ICH are based on weak literature evidence. In the present article, the Authors provide a review on VTE prevention in ICH and propose a practical algorithm for clinical management of this topic.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Venous Thromboembolism Prevention in Spontaneous Intracerebral Hemorrhage
AU  - Luca Masotti
AU  - Mario Di Napoli
AU  - Daniel Agustin Godoy
AU  - Grazia Panigada
AU  - Stefano Spolveri
AU  - Gianni Lorenzini
AU  - Giancarlo Landini
Y1  - 2015/06/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ijcems.20150102.13
DO  - 10.11648/j.ijcems.20150102.13
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 16
EP  - 21
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20150102.13
AB  - Venous thromboembolism (VTE), encompassing for deep vein thrombosis (DVT) and pulmonary embolism (PE), represents the most feared complication in patients suffering from spontaneous intracerebral hemorrhage (ICH). The balance between VTE risk and the risk of hematoma expansion and/or re-bleeding is the cornerstone of prophylaxis which is based on non-pharmacological and pharmacological strategies. In the latest years results of three randomized clinical trials on non-pharmacological prophylaxis in ischemic and hemorrhagic stroke have been published. Intermittent pneumatic compression has shown to be effective in ICH compared to placebo, whereas graduated compression stockings failed to show their superiority over placebo. Few and low quality studies reported on pharmacological prophylaxis in ICH. Overall, these studies showed that pharmacological prophylaxis could be safe, but whether it is more effective than other non-pharmacological methods remains unclear. A meta-analysis of four randomized controlled studies showed that pharmacological prophylaxis significantly reduces the rate of pulmonary embolism. Consequently, recommendations from Scientific Societies for VTE prevention in ICH are based on weak literature evidence. In the present article, the Authors provide a review on VTE prevention in ICH and propose a practical algorithm for clinical management of this topic.
VL  - 1
IS  - 2
ER  -

Copy | Download