Aqueous Synthesis and Biological Studies of Indole Derivatives
American Journal of Heterocyclic Chemistry
Volume 2, Issue 1, December 2016, Pages: 13-19
Received: Oct. 26, 2016; Accepted: Nov. 12, 2016; Published: Dec. 27, 2016
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Authors
Sudhakara Aralihalli, Department of Chemistry, Jain Institute of Technology, Davanagere, India
Raghavendra Ramappa, Department of Micro Biology & Cell biology, Indian Institute of Science, Bengaluru, India
Harish Basavanthappa Gowdru, Department of Biotechnology, M. S. RIT, Bengaluru, India
Nataraja Gummanar, Department of Chemistry, Jain Institute of Technology, Davanagere, India
Ramesha Sonnappa, R&D Center Department of Chemistry, Rajarajeswari College of Engineering, Bengaluru, India
Mahadevan Kittappa Malavalli, Department of Chemistry, Kuvempu University, Karnataka, India
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Abstract
One pot with expedient approach to the synthesis of 2,3-disubstituted indole derivatives using indium (III) trichloride through Fisher indole method has been developed, in aqueous media. The synthesized compounds were screened for their anti analgesic and antibacterial activity. All the six indole derivatives exhibited significant antibacterial activity against Pseudomonas aeruginosa when compared to standard drug Ciprofloxacin. Based on the results of antibacterial activity, the molecular docking of all six indole derivatives were performed against Pseudomonas elastase a matrix metalloproteinase from Pseudomonas aeruginosa were presumed as an infectious wound healer via MMP dependent pathway. The active pocket docked with indole derivatives at the torsional degree of freedom 0.5 units with Lamarckian genetic algorithm. The inhibitors binding is facilitated by direct hydrogen bond interactions with the residues residing in the catalytic motif of Pseudomonas elastase consisted of Ala113, His140, Glu141, His144, Glu164, Arg198 and His223. In addition, the inhibitors make many hydrophobic interactions with both the enzyme and the co-factor Zinc ion. In view of the possibility that the elastase is an important determinant in Pseudomonas infection, it is conceivable that inhibitors of the enzyme will reduce its destructive effects that may lead to new therapeutic intervention.
Keywords
Fischer Indole, Indium (III) Chloride, EMK, Phenyl Hydrazine Hydrochloride, Molecular Docking, Pseudomonas Elastase
To cite this article
Sudhakara Aralihalli, Raghavendra Ramappa, Harish Basavanthappa Gowdru, Nataraja Gummanar, Ramesha Sonnappa, Mahadevan Kittappa Malavalli, Aqueous Synthesis and Biological Studies of Indole Derivatives, American Journal of Heterocyclic Chemistry. Vol. 2, No. 1, 2016, pp. 13-19. doi: 10.11648/j.ajhc.20160201.13
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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