Nanoscience and Nanometrology

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DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application

Received: 07 July 2015    Accepted: 28 July 2015    Published: 29 July 2015
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Abstract

The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promising drug delivery method for patients who suffer from chronic and crippling Central Nervous System diseases. Among the formulation strategies for enhanced nose to brain drug delivery, the use of colloidal carriers has became a revolutionary approach. The success of a therapeutic strategy by using nanocarriers depends on their ability to entrap drugs, to penetrate through anatomical barriers, to efficiently release the incorporated drugs, to show a good stability in nanometric size range and good biocompatibility. The use of vesicular systems (niosomes), in nose to brain delivery is here presented. One of the major problems associated with nasal administration is the rapid removal of drugs or drug delivery systems, from the deposition site through mucociliary clearance. This effect is responsible of reduction of contact time between drug or drug delivery systems and nasal epithelium. This problem could be solved by coating nanocarriers with a mucoadhesive agent: chitosan. In this paper the preparation and characterization of hybrid niosomes by Tween 20 and Tween 21 together with dicetyl phosphate or Span 20 and the cationic polyelectrolyte chitosan are described in order to obtain intranasal drug delivery systems. In particular through dynamic light scattering, laser Doppler electrophoresis and fluorescence measurements the aggregation behavior between vesicles and polyelectrolyte can be monitored. Overall phenomenology is well described in terms of the re-entrant condensation and charge inversion behavior, observed in different colloidal systems. The physical stability of hybrid niosomes obtained by the three different surfactants was also evaluated

DOI 10.11648/j.nsnm.20150101.12
Published in Nanoscience and Nanometrology (Volume 1, Issue 1, December 2015)
Page(s) 8-14
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Niosomes, Chitosan, Dynamic Light Scattering, Laser Doppler Electrophoresis, Fluorescence

References
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[3] C. Marianecci, L. Di Marzio, F. Rinaldi, C. Celia, D. Paolino, F. Alhaique, S. Esposito and M. Carafa, “Niosomes from 80s to present: The state of the art”, Adv. Colloid Interface Sci., vol. 205, pp. 187–206, 2014.
[4] M. Estanqueiro, M. H. Amaral, J. Conceição and J. M. Sousa Lobo, “Nanotechnological carriers for cancer chemotherapy: The state of the art”, Coll. Surf. B Biointerfaces, vol. 126, pp. 631-648, 2015.
[5] K. K. Jain, “Drug Delivery to the Central Nervous System”, Berlin and Heidelberg:Springer, 2010.
[6] S. V. Dhuria, L. R. Hanson and W. H. Frey 2nd, “Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations”, J. Pharm. Sci., vol. 99, pp. 1654-1673, 2010.
[7] F. Uchegbu and A. T. Florence, “Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry”, Adv. Colloid Interface Sci., vol. 58, pp. 1-55, 1995.
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[9] M. Carafa, C. Marianecci, G. Lucania, E. Marchei and E. Santucci, “New vesicular ampicillin-loaded delivery systems for topical application: characterization, in vitro permeation experiments and antimicrobial activity”, J. Controlled Release, vol. 95, pp. 67–74, 2004.
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Author Information
  • Center for Life Nano Science@Sapienza, Fondazione Istituto Italiano di Tecnologia, Rome, Italy

  • Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy

  • Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy

  • Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy

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    Federica Rinaldi, Patrizia N. Hanieh, Carlotta Marianecci, Maria Carafa. (2015). DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application. Nanoscience and Nanometrology, 1(1), 8-14. https://doi.org/10.11648/j.nsnm.20150101.12

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    ACS Style

    Federica Rinaldi; Patrizia N. Hanieh; Carlotta Marianecci; Maria Carafa. DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application. Nanosci. Nanometrol. 2015, 1(1), 8-14. doi: 10.11648/j.nsnm.20150101.12

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    AMA Style

    Federica Rinaldi, Patrizia N. Hanieh, Carlotta Marianecci, Maria Carafa. DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application. Nanosci Nanometrol. 2015;1(1):8-14. doi: 10.11648/j.nsnm.20150101.12

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  • @article{10.11648/j.nsnm.20150101.12,
      author = {Federica Rinaldi and Patrizia N. Hanieh and Carlotta Marianecci and Maria Carafa},
      title = {DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application},
      journal = {Nanoscience and Nanometrology},
      volume = {1},
      number = {1},
      pages = {8-14},
      doi = {10.11648/j.nsnm.20150101.12},
      url = {https://doi.org/10.11648/j.nsnm.20150101.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.nsnm.20150101.12},
      abstract = {The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promising drug delivery method for patients who suffer from chronic and crippling Central Nervous System diseases. Among the formulation strategies for enhanced nose to brain drug delivery, the use of colloidal carriers has became a revolutionary approach. The success of a therapeutic strategy by using nanocarriers depends on their ability to entrap drugs, to penetrate through anatomical barriers, to efficiently release the incorporated drugs, to show a good stability in nanometric size range and good biocompatibility. The use of vesicular systems (niosomes), in nose to brain delivery is here presented. One of the major problems associated with nasal administration is the rapid removal of drugs or drug delivery systems, from the deposition site through mucociliary clearance. This effect is responsible of reduction of contact time between drug or drug delivery systems and nasal epithelium. This problem could be solved by coating nanocarriers with a mucoadhesive agent: chitosan. In this paper the preparation and characterization of hybrid niosomes by Tween 20 and Tween 21 together with dicetyl phosphate or Span 20 and the cationic polyelectrolyte chitosan are described in order to obtain intranasal drug delivery systems. In particular through dynamic light scattering, laser Doppler electrophoresis and fluorescence measurements the aggregation behavior between vesicles and polyelectrolyte can be monitored. Overall phenomenology is well described in terms of the re-entrant condensation and charge inversion behavior, observed in different colloidal systems. The physical stability of hybrid niosomes obtained by the three different surfactants was also evaluated},
     year = {2015}
    }
    

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    T1  - DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application
    AU  - Federica Rinaldi
    AU  - Patrizia N. Hanieh
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    UR  - https://doi.org/10.11648/j.nsnm.20150101.12
    AB  - The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promising drug delivery method for patients who suffer from chronic and crippling Central Nervous System diseases. Among the formulation strategies for enhanced nose to brain drug delivery, the use of colloidal carriers has became a revolutionary approach. The success of a therapeutic strategy by using nanocarriers depends on their ability to entrap drugs, to penetrate through anatomical barriers, to efficiently release the incorporated drugs, to show a good stability in nanometric size range and good biocompatibility. The use of vesicular systems (niosomes), in nose to brain delivery is here presented. One of the major problems associated with nasal administration is the rapid removal of drugs or drug delivery systems, from the deposition site through mucociliary clearance. This effect is responsible of reduction of contact time between drug or drug delivery systems and nasal epithelium. This problem could be solved by coating nanocarriers with a mucoadhesive agent: chitosan. In this paper the preparation and characterization of hybrid niosomes by Tween 20 and Tween 21 together with dicetyl phosphate or Span 20 and the cationic polyelectrolyte chitosan are described in order to obtain intranasal drug delivery systems. In particular through dynamic light scattering, laser Doppler electrophoresis and fluorescence measurements the aggregation behavior between vesicles and polyelectrolyte can be monitored. Overall phenomenology is well described in terms of the re-entrant condensation and charge inversion behavior, observed in different colloidal systems. The physical stability of hybrid niosomes obtained by the three different surfactants was also evaluated
    VL  - 1
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