Biomedical Sciences

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Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression

Received: 15 May 2015    Accepted: 25 May 2015    Published: 26 May 2015
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Abstract

Beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been suggested to inhibit inflammation. However, its mechanism is not fully understood. Here we show that HMB repressed LPS-induced interleukin-6 (IL-6) expression by inhibiting the NF-B and AP-1 pathways. When protein phosphatase-1 (PP1) was knocked down, the effects of HMB were partly abrogated. We conclude that HMB might repress inflammation by modulating PP1 and its downstream NF-B and AP-1 pathways.

DOI 10.11648/j.bs.20150101.11
Published in Biomedical Sciences (Volume 1, Issue 1, May 2015)
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

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Keywords

Interleukin-6 (IL-6), NF-B (Nuclear Factor-B), p38, c-Jun N-terminal Kinase (JNK), Beta-hydroxy-beta-methylbutyrate (HMB)

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Author Information
  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan

  • Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • APA Style

    Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, et al. (2015). Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression. Biomedical Sciences, 1(1), 1-5. https://doi.org/10.11648/j.bs.20150101.11

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    ACS Style

    Mitsutaka Yakabe; Sumito Ogawa; Hidetaka Ota; Katsuya Iijima; Masato Eto, et al. Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression. Biomed. Sci. 2015, 1(1), 1-5. doi: 10.11648/j.bs.20150101.11

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    AMA Style

    Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, et al. Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression. Biomed Sci. 2015;1(1):1-5. doi: 10.11648/j.bs.20150101.11

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  • @article{10.11648/j.bs.20150101.11,
      author = {Mitsutaka Yakabe and Sumito Ogawa and Hidetaka Ota and Katsuya Iijima and Masato Eto and Yasuyoshi Ouchi and Masahiro Akishita},
      title = {Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression},
      journal = {Biomedical Sciences},
      volume = {1},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.bs.20150101.11},
      url = {https://doi.org/10.11648/j.bs.20150101.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bs.20150101.11},
      abstract = {Beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been suggested to inhibit inflammation. However, its mechanism is not fully understood. Here we show that HMB repressed LPS-induced interleukin-6 (IL-6) expression by inhibiting the NF-B and AP-1 pathways. When protein phosphatase-1 (PP1) was knocked down, the effects of HMB were partly abrogated. We conclude that HMB might repress inflammation by modulating PP1 and its downstream NF-B and AP-1 pathways.},
     year = {2015}
    }
    

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    T1  - Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression
    AU  - Mitsutaka Yakabe
    AU  - Sumito Ogawa
    AU  - Hidetaka Ota
    AU  - Katsuya Iijima
    AU  - Masato Eto
    AU  - Yasuyoshi Ouchi
    AU  - Masahiro Akishita
    Y1  - 2015/05/26
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    N1  - https://doi.org/10.11648/j.bs.20150101.11
    DO  - 10.11648/j.bs.20150101.11
    T2  - Biomedical Sciences
    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2575-3932
    UR  - https://doi.org/10.11648/j.bs.20150101.11
    AB  - Beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been suggested to inhibit inflammation. However, its mechanism is not fully understood. Here we show that HMB repressed LPS-induced interleukin-6 (IL-6) expression by inhibiting the NF-B and AP-1 pathways. When protein phosphatase-1 (PP1) was knocked down, the effects of HMB were partly abrogated. We conclude that HMB might repress inflammation by modulating PP1 and its downstream NF-B and AP-1 pathways.
    VL  - 1
    IS  - 1
    ER  - 

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