Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 3, Issue 3) |
| DOI | 10.11648/j.ajpn.20150303.11 |
| Page(s) | 40-49 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Multiple Sclerosis, Brain Atrophy, Brain Volume Loss
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APA Style
Rugilo Carlos, Seifer Gustavo, Kuperman Gaston, Villa Andrés María. (2015). Brain atrophy in Multiple Sclerosis. American Journal of Psychiatry and Neuroscience, 3(3), 40-49. https://doi.org/10.11648/j.ajpn.20150303.11
ACS Style
Rugilo Carlos; Seifer Gustavo; Kuperman Gaston; Villa Andrés María. Brain atrophy in Multiple Sclerosis. Am. J. Psychiatry Neurosci. 2015, 3(3), 40-49. doi: 10.11648/j.ajpn.20150303.11
AMA Style
Rugilo Carlos, Seifer Gustavo, Kuperman Gaston, Villa Andrés María. Brain atrophy in Multiple Sclerosis. Am J Psychiatry Neurosci. 2015;3(3):40-49. doi: 10.11648/j.ajpn.20150303.11
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Download@article{10.11648/j.ajpn.20150303.11,
author = {Rugilo Carlos and Seifer Gustavo and Kuperman Gaston and Villa Andrés María},
title = {Brain atrophy in Multiple Sclerosis},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {3},
number = {3},
pages = {40-49},
doi = {10.11648/j.ajpn.20150303.11},
url = {https://doi.org/10.11648/j.ajpn.20150303.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20150303.11},
abstract = {Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS.},
year = {2015}
}
TY - JOUR T1 - Brain atrophy in Multiple Sclerosis AU - Rugilo Carlos AU - Seifer Gustavo AU - Kuperman Gaston AU - Villa Andrés María Y1 - 2015/03/31 PY - 2015 N1 - https://doi.org/10.11648/j.ajpn.20150303.11 DO - 10.11648/j.ajpn.20150303.11 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 40 EP - 49 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20150303.11 AB - Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS. VL - 3 IS - 3 ER -
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