Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Zhuqing Qu-Petersen

doi:doi:10.11648/j.ajpn.20160405.13

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Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Zhuqing Qu-Petersen

Published in American Journal of Psychiatry and Neuroscience (Volume 4, Issue 5)

Received: 19 September 2016 Accepted: Published: 19 September 2016

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Abstract

Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP’s unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.

Published in	American Journal of Psychiatry and Neuroscience (Volume 4, Issue 5)
DOI	10.11648/j.ajpn.20160405.13
Page(s)	79-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Neuroepithelial Myogenic Progenitors, Chimeric Grafts, Rhabdomyosarcoma, Embryonal Tumors, Brain, Skeletal Muscle

References

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APA Style

Zhuqing Qu-Petersen. (2016). Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. American Journal of Psychiatry and Neuroscience, 4(5), 79-86. https://doi.org/10.11648/j.ajpn.20160405.13

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ACS Style

Zhuqing Qu-Petersen. Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. Am. J. Psychiatry Neurosci. 2016, 4(5), 79-86. doi: 10.11648/j.ajpn.20160405.13

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AMA Style

Zhuqing Qu-Petersen. Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. Am J Psychiatry Neurosci. 2016;4(5):79-86. doi: 10.11648/j.ajpn.20160405.13

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@article{10.11648/j.ajpn.20160405.13,
  author = {Zhuqing Qu-Petersen},
  title = {Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {4},
  number = {5},
  pages = {79-86},
  doi = {10.11648/j.ajpn.20160405.13},
  url = {https://doi.org/10.11648/j.ajpn.20160405.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20160405.13},
  abstract = {Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP’s unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.},
 year = {2016}
}

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TY  - JOUR
T1  - Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors
AU  - Zhuqing Qu-Petersen
Y1  - 2016/09/19
PY  - 2016
N1  - https://doi.org/10.11648/j.ajpn.20160405.13
DO  - 10.11648/j.ajpn.20160405.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20160405.13
AB  - Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP’s unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.
VL  - 4
IS  - 5
ER  -

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Author Information

Zhuqing Qu-Petersen

The Copenhagen Muscle Research Centre, National University Hospital, Copenhagen, Denmark

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Plain Text BibTeX RIS

APA Style

Zhuqing Qu-Petersen. (2016). Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. American Journal of Psychiatry and Neuroscience, 4(5), 79-86. https://doi.org/10.11648/j.ajpn.20160405.13

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ACS Style

Zhuqing Qu-Petersen. Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. Am. J. Psychiatry Neurosci. 2016, 4(5), 79-86. doi: 10.11648/j.ajpn.20160405.13

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AMA Style

Zhuqing Qu-Petersen. Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors. Am J Psychiatry Neurosci. 2016;4(5):79-86. doi: 10.11648/j.ajpn.20160405.13

Copy | Download

@article{10.11648/j.ajpn.20160405.13,
  author = {Zhuqing Qu-Petersen},
  title = {Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {4},
  number = {5},
  pages = {79-86},
  doi = {10.11648/j.ajpn.20160405.13},
  url = {https://doi.org/10.11648/j.ajpn.20160405.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20160405.13},
  abstract = {Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP’s unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors
AU  - Zhuqing Qu-Petersen
Y1  - 2016/09/19
PY  - 2016
N1  - https://doi.org/10.11648/j.ajpn.20160405.13
DO  - 10.11648/j.ajpn.20160405.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20160405.13
AB  - Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP’s unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.
VL  - 4
IS  - 5
ER  -

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