Chitotriosidase Activity in Different Stages of Hepatitis C. It may a Possible Tumor Marker for Hepatocellular Carcinoma
Journal of Cancer Treatment and Research
Volume 2, Issue 1, January 2014, Pages: 5-8
Received: Dec. 24, 2013; Published: Mar. 10, 2014
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Authors
Engin ALTINTAS, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye; Mersin Universitesi Tip Fakultesi Zeytinlibahce Cad. Eskiotogar Yani Ic Hastaliklari A.D. 33079 Mersin Türkiye
Serkan Yaras, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye
Burak CIMEN, Mersin University Faculty of Medicine, Biochemistry Dept., Mersin, Türkiye
Enver UCBILEK, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye
Bunyamin SARITAS, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye
Fehmi ATES, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye
Orhan SEZGIN, Mersin University Faculty of Medicine, Gastroenterology Dept., Mersin, Türkiye
Gulhan OREKECI, Mersin University Faculty of Medicine, Biochemistry Dept., Mersin, Türkiye
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Abstract
Chitotriosidase is synthesized and secreted especially in activated macrophages. The aim of this study was to evaluate chitotriosidase activity in patients with various stages of hepatitis C. The study included a total of 90 patients. The patients were divided into four groups. Group 1 included 54 patients with chronic active hepatitis, Group 2 included 20 patients with recovered HCV, Group 3 included 6 patients with HCV induced hepatocellular carcinoma, and Group 4 included 10 patients with HCV cirrhosis. Chitotriosidase activity was measured with spectrophotometry (SigmaAldrich ®). The mean chitotriosidase activity of the four groups was 0,927u/L (0.804u/L in Group 1, 0.521u/L in Group 2, 3.211u/L in Group 3 and 1.030u/L in Group 4). Chitotriosidase activity was significantly higher in Group 3. ROC analysis, used to evaluate chitotriosidase activity for the diagnosis of hepatocellular carcinoma, showed that chitotriosidase activity of 0,935 was below the curve (CI: 95%; 0,862 - 0,976), which was statistically significant (p= 0,0001). The cut-off value was >1,098 with a sensitivity of 100% and a specifity of 81%. Chitotriosidase activity can be a marker with a high sensitivity and specifity for the diagnosis of hepatocellular carcinoma.
Keywords
Chitotriosidase, Hepatitis C, Hepatocellular Carcinoma
To cite this article
Engin ALTINTAS, Serkan Yaras, Burak CIMEN, Enver UCBILEK, Bunyamin SARITAS, Fehmi ATES, Orhan SEZGIN, Gulhan OREKECI, Chitotriosidase Activity in Different Stages of Hepatitis C. It may a Possible Tumor Marker for Hepatocellular Carcinoma, Journal of Cancer Treatment and Research. Vol. 2, No. 1, 2014, pp. 5-8. doi: 10.11648/j.jctr.20140201.12
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