Journal of Cancer Treatment and Research

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Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study

Received: 11 September 2015    Accepted: 24 September 2015    Published: 13 October 2015
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Abstract

Background: Pancreatic adenocarcinoma (PAC) is one of the most fatal human malignancies and complete surgical resection is the only treatment that offers a hope for prolonged survival. However, even after curative resection, the overall 5-year survival rate is only 10%-29%. Aim: we aimed to examine the preoperative and operative predictors for survival following radical resection of PAC. Methods: Twenty-four patients with ductal adenocarcinoma of the head of pancreas who had undergone pancreatoduodenectomy at South Egypt Cancer Institute, Assiut University, between January 2010 and December 2011, were recruited. Results: The follow-up time ranged from 2 to 36 months with a median of 14 months. Univariate analysis revealed that anorexia, weight loss, pre-operative anaemia, hypoalbuminemia, obstructive jaundice, pre-operative transfusions, WHO performance scale, presence of preoperative morbidities and tumor size were associated with the patients survival. Of the previous factors, pre-operative hemoglobin level (<10mg/dl), pre-operative serum albumin level (<30mg/dl), pre-operative transfusions (blood and albumin), and tumor size were found to influence the overall survival on the multivariate Cox Hazard Regression analysis. Conclusion: The current study concluded that preoperative malnutrition (due to anorexia, anaemia, hypoalbumineamia and preoperative transfusions) and large tumor size (>T2) were associated with poor outcome after surgical resection.

DOI 10.11648/j.jctr.20150304.11
Published in Journal of Cancer Treatment and Research (Volume 3, Issue 4, July 2015)
Page(s) 47-52
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Adenocarcinoma, Hypoalbuminemia, Pancreas, Pancreaticoduodenectomy, Pancreatic Carcinoma, Survival Rate

References
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Author Information
  • Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

  • Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt

  • Community Health School, Faculty of Medicine, Assiut University, Assiut, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

  • Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

  • General Surgery Department, Faculty of Medicine, Assiut University, Assiut, Egypt

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  • APA Style

    Hussein Fakhry, Mohamed Abdelsabor Mekky, Ahmed Khair Ibrahim, Wael Ahmed Abbas, Tarek Mohamed Elsaba, et al. (2015). Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study. Journal of Cancer Treatment and Research, 3(4), 47-52. https://doi.org/10.11648/j.jctr.20150304.11

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    ACS Style

    Hussein Fakhry; Mohamed Abdelsabor Mekky; Ahmed Khair Ibrahim; Wael Ahmed Abbas; Tarek Mohamed Elsaba, et al. Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study. J. Cancer Treat. Res. 2015, 3(4), 47-52. doi: 10.11648/j.jctr.20150304.11

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    AMA Style

    Hussein Fakhry, Mohamed Abdelsabor Mekky, Ahmed Khair Ibrahim, Wael Ahmed Abbas, Tarek Mohamed Elsaba, et al. Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study. J Cancer Treat Res. 2015;3(4):47-52. doi: 10.11648/j.jctr.20150304.11

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  • @article{10.11648/j.jctr.20150304.11,
      author = {Hussein Fakhry and Mohamed Abdelsabor Mekky and Ahmed Khair Ibrahim and Wael Ahmed Abbas and Tarek Mohamed Elsaba and Mohamed Korany},
      title = {Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study},
      journal = {Journal of Cancer Treatment and Research},
      volume = {3},
      number = {4},
      pages = {47-52},
      doi = {10.11648/j.jctr.20150304.11},
      url = {https://doi.org/10.11648/j.jctr.20150304.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20150304.11},
      abstract = {Background: Pancreatic adenocarcinoma (PAC) is one of the most fatal human malignancies and complete surgical resection is the only treatment that offers a hope for prolonged survival. However, even after curative resection, the overall 5-year survival rate is only 10%-29%. Aim: we aimed to examine the preoperative and operative predictors for survival following radical resection of PAC. Methods: Twenty-four patients with ductal adenocarcinoma of the head of pancreas who had undergone pancreatoduodenectomy at South Egypt Cancer Institute, Assiut University, between January 2010 and December 2011, were recruited. Results: The follow-up time ranged from 2 to 36 months with a median of 14 months. Univariate analysis revealed that anorexia, weight loss, pre-operative anaemia, hypoalbuminemia, obstructive jaundice, pre-operative transfusions, WHO performance scale, presence of preoperative morbidities and tumor size were associated with the patients survival. Of the previous factors, pre-operative hemoglobin level (<10mg/dl), pre-operative serum albumin level (<30mg/dl), pre-operative transfusions (blood and albumin), and tumor size were found to influence the overall survival on the multivariate Cox Hazard Regression analysis. Conclusion: The current study concluded that preoperative malnutrition (due to anorexia, anaemia, hypoalbumineamia and preoperative transfusions) and large tumor size (>T2) were associated with poor outcome after surgical resection.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Pre-Operative and Operative Predictors of Survival of Resectable Cancer Head of Pancreas: A Retrospective Study
    AU  - Hussein Fakhry
    AU  - Mohamed Abdelsabor Mekky
    AU  - Ahmed Khair Ibrahim
    AU  - Wael Ahmed Abbas
    AU  - Tarek Mohamed Elsaba
    AU  - Mohamed Korany
    Y1  - 2015/10/13
    PY  - 2015
    N1  - https://doi.org/10.11648/j.jctr.20150304.11
    DO  - 10.11648/j.jctr.20150304.11
    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
    SP  - 47
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2376-7790
    UR  - https://doi.org/10.11648/j.jctr.20150304.11
    AB  - Background: Pancreatic adenocarcinoma (PAC) is one of the most fatal human malignancies and complete surgical resection is the only treatment that offers a hope for prolonged survival. However, even after curative resection, the overall 5-year survival rate is only 10%-29%. Aim: we aimed to examine the preoperative and operative predictors for survival following radical resection of PAC. Methods: Twenty-four patients with ductal adenocarcinoma of the head of pancreas who had undergone pancreatoduodenectomy at South Egypt Cancer Institute, Assiut University, between January 2010 and December 2011, were recruited. Results: The follow-up time ranged from 2 to 36 months with a median of 14 months. Univariate analysis revealed that anorexia, weight loss, pre-operative anaemia, hypoalbuminemia, obstructive jaundice, pre-operative transfusions, WHO performance scale, presence of preoperative morbidities and tumor size were associated with the patients survival. Of the previous factors, pre-operative hemoglobin level (<10mg/dl), pre-operative serum albumin level (<30mg/dl), pre-operative transfusions (blood and albumin), and tumor size were found to influence the overall survival on the multivariate Cox Hazard Regression analysis. Conclusion: The current study concluded that preoperative malnutrition (due to anorexia, anaemia, hypoalbumineamia and preoperative transfusions) and large tumor size (>T2) were associated with poor outcome after surgical resection.
    VL  - 3
    IS  - 4
    ER  - 

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