Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluate its possible thrombolysis and to analyze in –vivo neuro-pharmacological effects as anxiety is a particular form of behavioral inhibition that occurs in response to novel environment events and also phytochemical screening of plant extract. Method: Ethanolic extract of Argyria captiformis Leaves was assessed for sedative and anxiolytic activity on Swiss albino mice and Thrombolytic activity was assessed with human blood and also phytochemical screening test was done by various chemical reagents. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and anxiolytic property was evaluated by elevated-plus maze(EPM) tests at 400mg/kg while the peripheral and thrombolytic activity determined by percentage of clot lysis. Result: In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at doses (400 mg/kg) .The extract (400 mg/kg) also showed suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. Argyria captiformis alone & Argyria captiformis in combination with Streptokinase demonstrated 38.19±4.76% & 77.45±2.97% clot lysis effect respectively & revealed significant with comparison to both the control agent. The presence of tannins, glycosides, saponins, flavonoids, cardiac glycosides, and phytosterols was determined. Conclusion: The pharmacological profiles of the present investigation of the ethanol extract of A. captiformis indicate that the extract possess good CNS depressant and exhibited considerable thrombolytic as it significantly reduced locomotion, onset of sleep, increased duration of sleep and also presence of, glycosides, cardiac glycosides, saponins, flavonoids ,tannins and phytosterols.
| DOI | 10.11648/j.ajbls.20150302.12 |
| Published in | American Journal of Biomedical and Life Sciences (Volume 3, Issue 2, April 2015) |
| Page(s) | 16-24 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sedative and Anxiolytic Activity, Phytochemical, Argyria Captiformis, Thrombolytic Activity, % Lysis of Clot
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APA Style
Saiful Islam, Naymul Karim, Imam Hasan, Md Hossan Sakib, Md. Harun-Or- Rashid, et al. (2015). Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves. American Journal of Biomedical and Life Sciences, 3(2), 16-24. https://doi.org/10.11648/j.ajbls.20150302.12
ACS Style
Saiful Islam; Naymul Karim; Imam Hasan; Md Hossan Sakib; Md. Harun-Or- Rashid, et al. Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves. Am. J. Biomed. Life Sci. 2015, 3(2), 16-24. doi: 10.11648/j.ajbls.20150302.12
AMA Style
Saiful Islam, Naymul Karim, Imam Hasan, Md Hossan Sakib, Md. Harun-Or- Rashid, et al. Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves. Am J Biomed Life Sci. 2015;3(2):16-24. doi: 10.11648/j.ajbls.20150302.12
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Download@article{10.11648/j.ajbls.20150302.12,
author = {Saiful Islam and Naymul Karim and Imam Hasan and Md Hossan Sakib and Md. Harun-Or- Rashid and Sadequr Rahman and Masudur Rahman},
title = {Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves},
journal = {American Journal of Biomedical and Life Sciences},
volume = {3},
number = {2},
pages = {16-24},
doi = {10.11648/j.ajbls.20150302.12},
url = {https://doi.org/10.11648/j.ajbls.20150302.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20150302.12},
abstract = {Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluate its possible thrombolysis and to analyze in –vivo neuro-pharmacological effects as anxiety is a particular form of behavioral inhibition that occurs in response to novel environment events and also phytochemical screening of plant extract. Method: Ethanolic extract of Argyria captiformis Leaves was assessed for sedative and anxiolytic activity on Swiss albino mice and Thrombolytic activity was assessed with human blood and also phytochemical screening test was done by various chemical reagents. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and anxiolytic property was evaluated by elevated-plus maze(EPM) tests at 400mg/kg while the peripheral and thrombolytic activity determined by percentage of clot lysis. Result: In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at doses (400 mg/kg) .The extract (400 mg/kg) also showed suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. Argyria captiformis alone & Argyria captiformis in combination with Streptokinase demonstrated 38.19±4.76% & 77.45±2.97% clot lysis effect respectively & revealed significant with comparison to both the control agent. The presence of tannins, glycosides, saponins, flavonoids, cardiac glycosides, and phytosterols was determined. Conclusion: The pharmacological profiles of the present investigation of the ethanol extract of A. captiformis indicate that the extract possess good CNS depressant and exhibited considerable thrombolytic as it significantly reduced locomotion, onset of sleep, increased duration of sleep and also presence of, glycosides, cardiac glycosides, saponins, flavonoids ,tannins and phytosterols.},
year = {2015}
}
TY - JOUR T1 - Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves AU - Saiful Islam AU - Naymul Karim AU - Imam Hasan AU - Md Hossan Sakib AU - Md. Harun-Or- Rashid AU - Sadequr Rahman AU - Masudur Rahman Y1 - 2015/04/10 PY - 2015 N1 - https://doi.org/10.11648/j.ajbls.20150302.12 DO - 10.11648/j.ajbls.20150302.12 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 16 EP - 24 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20150302.12 AB - Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluate its possible thrombolysis and to analyze in –vivo neuro-pharmacological effects as anxiety is a particular form of behavioral inhibition that occurs in response to novel environment events and also phytochemical screening of plant extract. Method: Ethanolic extract of Argyria captiformis Leaves was assessed for sedative and anxiolytic activity on Swiss albino mice and Thrombolytic activity was assessed with human blood and also phytochemical screening test was done by various chemical reagents. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and anxiolytic property was evaluated by elevated-plus maze(EPM) tests at 400mg/kg while the peripheral and thrombolytic activity determined by percentage of clot lysis. Result: In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at doses (400 mg/kg) .The extract (400 mg/kg) also showed suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. Argyria captiformis alone & Argyria captiformis in combination with Streptokinase demonstrated 38.19±4.76% & 77.45±2.97% clot lysis effect respectively & revealed significant with comparison to both the control agent. The presence of tannins, glycosides, saponins, flavonoids, cardiac glycosides, and phytosterols was determined. Conclusion: The pharmacological profiles of the present investigation of the ethanol extract of A. captiformis indicate that the extract possess good CNS depressant and exhibited considerable thrombolytic as it significantly reduced locomotion, onset of sleep, increased duration of sleep and also presence of, glycosides, cardiac glycosides, saponins, flavonoids ,tannins and phytosterols. VL - 3 IS - 2 ER -
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