Determinants of None-Adherence to Antiretroviral Therapy among HIV-Infected Adults in Arba Minch General Hospital, Gamo Gofa Zone, Southern Ethiopia: A Case Control Study
American Journal of Health Research
Volume 2, Issue 5, September 2014, Pages: 234-240
Received: Aug. 19, 2014; Accepted: Sep. 3, 2014; Published: Sep. 20, 2014
Views 1709      Downloads 216
Authors
Belay Dagnaw Bitew, Arba Minch University, Department of Public Health, Arba Minch Ethiopia
Yemane Berehane, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia
Eskezyiaw Agedew Getahun, Arba Minch University, Department of Public Health, Arba Minch Ethiopia
Direslgne Misker Abyu, Arba Minch University, Department of Public Health, Arba Minch Ethiopia
Article Tools
Follow on us
Abstract
Background: Non-adherence to antiretroviral therapy is a major challenge to Acquired Immunodeficiency Syndrome (AIDS) care. For Antiretroviral Therapy (ART) to be effective, high level of adherence is required. In spite of this, there is no information on determinant none-adherence to antiretroviral therapy in the study area; therefore this study was conducted to identify predictors of none-adherence to antiretroviral therapy among People Living with HIV/AIDS (PLWHA) in Arba Minch General Hospital. Methods: Unmatched case-control study design was employed on 115 case and 347 controls. Non-adherence to ART is considered as case and adherence to ART is taken as control. Data was collected by using a structured pre-tested questionnaire and by using data abstraction format from ART registration chart. Binary logistic regression analysis was calculated to assess the presence and degree of association between dependent and independent variables; finally multivariate analysis was conducted to identify independent factors for none adherence. Result: From interviewed respondent majority of respondent 304(65.8%) were females and the rest 158(34.2%) were males. From all respondent 209(45%) were in age group 30-39 years. Factors like rural residence 6.30(3.01-13.15), PLWHA who has no family and community support 1.92(1.05-3.51), mobile phone adjusted odds ratio (AOR) 1.20(1.15-3.44)), alcohol drinker 5.88(2.86-12.09), malnutrition 2.83(1.18-6.77) and who consume low dietary diversity 7.18(3.43-15.04) and CD4 Count <250 cells/mm3 2.18(1.05-4.50) are the major identified significant factors for none adherence to ART treatment in the study area. Conclusion and recommendation: PLWHA, who has no family and community support, rural residence, not utilized mobile phone, alcohol drinker, under nutrition, who consume low dietary diversity and those with low CD4 count are major significant determinant factors for non-adherence to ART treatment. Therefore, the capacity to effectively manage the above critical factor is crucial in the success of antiretroviral therapy.
Keywords
Non-Adherence, Antiretroviral Therapy, Case Control, Southern Ethiopia
To cite this article
Belay Dagnaw Bitew, Yemane Berehane, Eskezyiaw Agedew Getahun, Direslgne Misker Abyu, Determinants of None-Adherence to Antiretroviral Therapy among HIV-Infected Adults in Arba Minch General Hospital, Gamo Gofa Zone, Southern Ethiopia: A Case Control Study, American Journal of Health Research. Vol. 2, No. 5, 2014, pp. 234-240. doi: 10.11648/j.ajhr.20140205.13
References
[1]
Berhe, N., D. Tegabu, and M. Alemayehu, Effect of nutritional factors on adherence to antiretroviral therapy among HIV-infected adults: a case control study in Northern Ethiopia. BMC infectious diseases. 13(1): p. 233.
[2]
Idindili, B., et al., A case-control study of factors associated with non-adherent to antiretroviral therapy among HIV infected people in Pwani Region, eastern Tanzania. Tanzania Journal of Health Research. 14(3).
[3]
Wakibi, S.N, Z. Nga, and G.G. Mbugua,Factors associated with non-adherence with highly active antiretroviral therapy in Nairobi, Kenya. AIDS Res Ther. 8: p. 43.
[4]
Mbuagbaw, L., et al., Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial. AIDS Res Ther. 9(1): p. 37.
[5]
Tadios, Y. and G. Davey, Antiretroviral treatment adherence and its correlates in Addis Ababa, Ethiopia. Ethiopian medical journal, 2006. 44(3): p. 237-244.
[6]
FAO, Baseline Survey Report Protecting and Improving Household Food Security and Nutrition in HIV/AIDS Affected Areas in Manica and Sofala Province, Maputo, Mozambique. 2006.
[7]
Tiyou A, et al., Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resource limited setting of southwest Ethiopia. . AIDS Research and Therapy 2010. 7(39).
[8]
Ayalu A, Reda Biad, and gilign S, Determinants of Adherence to Antiretroviral Therapy among HIV Infected Patients in Africa, AIDS Research and Treatment. 2012.
[9]
Markos, E., A. Worku, and G. Davey, Adherence to ART in PLWHA and Yirgalem Hospital, South Ethiopia. Ethiopian Journal of Health Development, 2009. 22(2): p. 174-179.
[10]
Teferra, S., et al., Perspectives on reasons for non-adherence to medication in persons with schizophrenia in Ethiopia: a qualitative study of patients, caregivers and health workers. BMC psychiatry. 13(1): p. 168.
[11]
Sanjobo, N., J.C. Frich, and A. Fretheim, Barriers and facilitators to patients\'adherence to antiretroviral treatment in Zambia: a qualitative study. SAHARA J (Journal of Social Aspects of HIV/AIDS Research Alliance), 2009. 5(3): p. 136-143.
[12]
Mukhtar-Yola, M., et al., Preliminary investigation of adherence to antiretroviral therapy among children in Aminu Kano Teaching Hospital, Nigeria. African Journal of AIDS Research, 2006. 5(2): p. 141-144.
[13]
Tran, B.X., et al., Determinants of antiretroviral treatment adherence among HIV/AIDS patients: a multisite study. Glob Health Action. 6(19570): p. 19570.
[14]
Huang D, et al., Effects of a Phone Call Intervention to Promote Adherence to Antiretroviral Therapy and Quality of Life of HIV/AIDS Patients in Baoshan,China: A Randomized Controlled Trial . Hindawi Publishing Corporation AIDS Research and Treatment., 2013.
[15]
Ehlers J and D.W. M., Patients adherence to anti-retroviral therapy in Botswana.Journal of Nursing Scholarship., 2009. 41(2): p. 149-157.
[16]
Cantrell, R.A., et al., A pilot study of food supplementation to improve adherence to antiretroviral therapy among food insecure adults in Lusaka, Zambia. Journal of acquired immune deficiency syndromes (1999), 2008. 49(2).
[17]
Daniel, M., F. Mazengia, and D. Birhanu, Nutritional status and associated factors among adult HIV/AIDS clients in Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia. Science. 1(1): p. 24-31.
[18]
Nyanzi-Wakholi, B., et al., The charms and challenges of antiretroviral therapy in Uganda: the DART experience. AIDS care. 24(2): p. 137-142.
[19]
Hailemariam, S., G.T. Bune, and H.T. Ayele, Malnutrition: Prevalence and its associated factors in People living with HIV/AIDS, in Dilla University Referral Hospital. Archives of Public Health. 71(1): p. 13.
[20]
Ivers, L.C., et al., HIV/AIDS, undernutrition, and food insecurity. Clinical Infectious Diseases, 2009. 49(7): p. 1096-1102.
[21]
Molly F, et al., Food Insufficiency is a Risk Factor for Suboptimal Antiretroviral Therapy Adherence among HIV-Infected Adults in Urban Peru. AIDS Behav, 2011. 15(7): p. 1483-1489.
[22]
Nyanzi-Wakholi B, et al., The charms and challenges of antiretroviral therapy in Uganda: the DART experience. AIDS Care 2012. 24(2): p. 137-142.
[23]
Adriana A, Paola TM, and Rita M, Correlates and predictors of adherence to Highly Active Antiretroviral Therapy. JAIDS 2002.
[24]
Mangili, A., et al., Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort. Clinical Infectious Diseases, 2006. 42(6): p. 836-842.
[25]
Prosperi, M.C., et al., Predictors of first-line antiretroviral therapy discontinuation due to drug-related adverse events in HIV-infected patients: a retrospective cohort study. BMC infectious diseases. 12(1): p. 296.
ADDRESS
Science Publishing Group
548 FASHION AVENUE
NEW YORK, NY 10018
U.S.A.
Tel: (001)347-688-8931