Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver

Maria L. Perepechaeva; Alevtina Yu. Grishanova

doi:doi:10.11648/j.ab.20130102.11

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Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver

Maria L. Perepechaeva, Alevtina Yu. Grishanova

Published in Advances in Biochemistry (Volume 1, Issue 2)

Received: 7 May 2013 Accepted: Published: 10 June 2013

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Abstract

During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.

Published in	Advances in Biochemistry (Volume 1, Issue 2)
DOI	10.11648/j.ab.20130102.11
Page(s)	7-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

CYP1A Activation, Cold, Rat Liver, Rat Lung, Tocopherol, α-TBP

References

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APA Style

Maria L. Perepechaeva, Alevtina Yu. Grishanova. (2013). Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Advances in Biochemistry, 1(2), 7-12. https://doi.org/10.11648/j.ab.20130102.11

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ACS Style

Maria L. Perepechaeva; Alevtina Yu. Grishanova. Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Adv. Biochem. 2013, 1(2), 7-12. doi: 10.11648/j.ab.20130102.11

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AMA Style

Maria L. Perepechaeva, Alevtina Yu. Grishanova. Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Adv Biochem. 2013;1(2):7-12. doi: 10.11648/j.ab.20130102.11

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@article{10.11648/j.ab.20130102.11,
  author = {Maria L. Perepechaeva and Alevtina Yu. Grishanova},
  title = {Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver},
  journal = {Advances in Biochemistry},
  volume = {1},
  number = {2},
  pages = {7-12},
  doi = {10.11648/j.ab.20130102.11},
  url = {https://doi.org/10.11648/j.ab.20130102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130102.11},
  abstract = {During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.},
 year = {2013}
}

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TY  - JOUR
T1  - Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver
AU  - Maria L. Perepechaeva
AU  - Alevtina Yu. Grishanova
Y1  - 2013/06/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ab.20130102.11
DO  - 10.11648/j.ab.20130102.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20130102.11
AB  - During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.
VL  - 1
IS  - 2
ER  -

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Author Information

Maria L. Perepechaeva

Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Russia
Alevtina Yu. Grishanova

Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Russia

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APA Style

Maria L. Perepechaeva, Alevtina Yu. Grishanova. (2013). Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Advances in Biochemistry, 1(2), 7-12. https://doi.org/10.11648/j.ab.20130102.11

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ACS Style

Maria L. Perepechaeva; Alevtina Yu. Grishanova. Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Adv. Biochem. 2013, 1(2), 7-12. doi: 10.11648/j.ab.20130102.11

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AMA Style

Maria L. Perepechaeva, Alevtina Yu. Grishanova. Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver. Adv Biochem. 2013;1(2):7-12. doi: 10.11648/j.ab.20130102.11

Copy | Download

@article{10.11648/j.ab.20130102.11,
  author = {Maria L. Perepechaeva and Alevtina Yu. Grishanova},
  title = {Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver},
  journal = {Advances in Biochemistry},
  volume = {1},
  number = {2},
  pages = {7-12},
  doi = {10.11648/j.ab.20130102.11},
  url = {https://doi.org/10.11648/j.ab.20130102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130102.11},
  abstract = {During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver
AU  - Maria L. Perepechaeva
AU  - Alevtina Yu. Grishanova
Y1  - 2013/06/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ab.20130102.11
DO  - 10.11648/j.ab.20130102.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20130102.11
AB  - During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.
VL  - 1
IS  - 2
ER  -

Copy | Download