Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of them in liver may induce cell inflammation, apoptosis and necrosis. While the hydrophilic bile acid, such as ursodeoxycholic acid, has a therapeutic effect on cholestatic liver diseases. Further more, recent researches demonstrate that bile acids have also been implicated in stimulation of liver regeneration. The antagonistic regulation of liver injury and liver regeneration by bile acids may correlate with its composition and concentration. This review will focus on both how different bile acids and different bile acid concentrations play a critical role in liver injury and regeneration.
| Published in | Advances in Biochemistry (Volume 2, Issue 6) |
| DOI | 10.11648/j.ab.20140206.11 |
| Page(s) | 85-89 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Bile Acids, Liver Injury, Liver Regeneration, UDCA
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APA Style
Xiaowen Tang, Lili Ding, Qiaoling Yang, Xiaoyuan Niu, Li Yang, et al. (2014). Advances in Bile Acids-Mediated Liver Injury and Liver Regeneration. Advances in Biochemistry, 2(6), 85-89. https://doi.org/10.11648/j.ab.20140206.11
ACS Style
Xiaowen Tang; Lili Ding; Qiaoling Yang; Xiaoyuan Niu; Li Yang, et al. Advances in Bile Acids-Mediated Liver Injury and Liver Regeneration. Adv. Biochem. 2014, 2(6), 85-89. doi: 10.11648/j.ab.20140206.11
AMA Style
Xiaowen Tang, Lili Ding, Qiaoling Yang, Xiaoyuan Niu, Li Yang, et al. Advances in Bile Acids-Mediated Liver Injury and Liver Regeneration. Adv Biochem. 2014;2(6):85-89. doi: 10.11648/j.ab.20140206.11
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Download@article{10.11648/j.ab.20140206.11,
author = {Xiaowen Tang and Lili Ding and Qiaoling Yang and Xiaoyuan Niu and Li Yang and Zhengtao Wang},
title = {Advances in Bile Acids-Mediated Liver Injury and Liver Regeneration},
journal = {Advances in Biochemistry},
volume = {2},
number = {6},
pages = {85-89},
doi = {10.11648/j.ab.20140206.11},
url = {https://doi.org/10.11648/j.ab.20140206.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140206.11},
abstract = {Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of them in liver may induce cell inflammation, apoptosis and necrosis. While the hydrophilic bile acid, such as ursodeoxycholic acid, has a therapeutic effect on cholestatic liver diseases. Further more, recent researches demonstrate that bile acids have also been implicated in stimulation of liver regeneration. The antagonistic regulation of liver injury and liver regeneration by bile acids may correlate with its composition and concentration. This review will focus on both how different bile acids and different bile acid concentrations play a critical role in liver injury and regeneration.},
year = {2014}
}
TY - JOUR T1 - Advances in Bile Acids-Mediated Liver Injury and Liver Regeneration AU - Xiaowen Tang AU - Lili Ding AU - Qiaoling Yang AU - Xiaoyuan Niu AU - Li Yang AU - Zhengtao Wang Y1 - 2014/11/28 PY - 2014 N1 - https://doi.org/10.11648/j.ab.20140206.11 DO - 10.11648/j.ab.20140206.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 85 EP - 89 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20140206.11 AB - Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of them in liver may induce cell inflammation, apoptosis and necrosis. While the hydrophilic bile acid, such as ursodeoxycholic acid, has a therapeutic effect on cholestatic liver diseases. Further more, recent researches demonstrate that bile acids have also been implicated in stimulation of liver regeneration. The antagonistic regulation of liver injury and liver regeneration by bile acids may correlate with its composition and concentration. This review will focus on both how different bile acids and different bile acid concentrations play a critical role in liver injury and regeneration. VL - 2 IS - 6 ER -
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