Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase

Marina Goryacheva; Grigori Shumakher; Liliya Kostyuchenko; Larisa Tsybirova; Peter Veselovsky; Sergey Fedyanin; Alexey Malikov; Oleg Komarov; Andrey Belousov; Maria Bondareva; Ksenia Goryacheva

doi:doi:10.11648/j.ab.20140206.13

Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase

Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, Sergey Fedyanin, Alexey Malikov, Oleg Komarov, Andrey Belousov, Maria Bondareva, Ksenia Goryacheva

Published in Advances in Biochemistry (Volume 2, Issue 6)

Received: 23 November 2014 Accepted: 9 December 2014 Published: 19 December 2014

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Abstract

The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.

Published in	Advances in Biochemistry (Volume 2, Issue 6)
DOI	10.11648/j.ab.20140206.13
Page(s)	95-102
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

C-Reactive Protein (hs-CRP), Interleukin-1 (IL-1), Endothelin – 1 (E-1), Lumbosacral Radiculopathies, Soluble Adhesion Molecules of Vascular Endothelium - 1 (sVCAM-1), Lumbalgia (Lumbodynia), Soluble Molecules of Intercellular Adhesion - 1 (sICAM-1), Lumboishialgia

References

[1]	Low Back pain initiative WHO 1999; 4.
[2]	Luo X., Pietrobon R., Sun S. et.al. Estimate and patterns of direct health care expenditures among individuals with back pain in the United States. Spain 2004; 29: 79 – 86.
[3]	http://www.russianseattle.com/sp/sinalneurology/2_popelyanskiy_in_usa_rus.shtml
[4]	http://www.russianseattle.com/sp/sinalneurology/index. shtml
[5]	http://www.russianseattle.com/sp/sinalneurology/2_about_my_father_ rus.shtml
[6]	Popelyansky G.G. Orthopedic Neurology (vertebroneurology): guidance for doctors./ G.G. Popelyansky –Moscow. MEDpress-inform 2003; 670 p.
[7]	Veselovsky V.P. Practical vertebrology and manual medicine. Riga 1991; 240 p.
[8]	Popelyansky Ya. Yu. Diseases of peripheral nervous system. Instructions for physicians doctors. Moscow. MEDpress-inform: Medicine 2005; 386 p.
[9]	Kuznetsov V.F. Vertebroneurology: clinic, diagnostic, treatment of spine diseases. Minsk. Book House 2004; 639 p.
[10]	Khabirov F.A. Clinical Neurology of Spyne. Kazan 2001; 472 p.
[11]	Antonov I.P. Problem of classification and formulation of a diagnose of vertebrogenic (spondylogenic) diseases of nervous system. Peripheral nervous system. Minsk, 1983; p. 49-56.
[12]	Veselovsky V.P., Ladygin A.P., Kochergina O.S.. Clinical classification of vertebrological syndromes. Neurology Bulletin. 1995; 27:3-4:45-50.
[13]	Zhulev N.M., Badzgaradze Yu.,D., Zhulev S.N.. Spinal osteochondrosis. Instructions for physicians. St. Petersburg. Lan 2001; 592 p.
[14]	Klinenko A.V., Kharchenko I.I. Application of non-steroidal anti-inflammatory drugs in complex treatment of myofascial vertebronic syndromes. Ukrainian Bulletin of psychoneurology. 2004; 2: 39: 10 – 11.
[15]	Likhachyova E.B., Sholomov I.I. Clinical-immune evaluation of mexidol effectiveness for lumbar sacral radiculopathy. Neurology and psychiatry journal. 2006; 10: 52 – 57.
[16]	Belyakov V.V., Sittel A.P., Sharapov I.N., Yeliseev N.P., Gurov Z.P. New outlook on formation of reflexory and compression syndromes of spinal osteochandrosis. Manual Therapy. терапия 2002; 3: 7: 20 - 25.
[17]	Novoseltsev S.V. Pathogenic mechanisms of the formathion of lumbar spondilogenic neurologic syndromes in patients with lumbar disk herniae. Manual Therapy. 2010; 3: 39: 77 – 82.
[18]	Zaslavsky E.S. Pain muscle syndromes. Novokuznetsk 1981; 12 p.
[19]	Kruglov V.N., Mokhov D.E. Gainutdinov A.R., Kruglov V.A.. Postural disfunctions in Patients with Lumbar Radicular and Pseudoradicular Syndromes, Osteopathic Correction. Undernational symposium “Functional manual medicine. Theory and Practice”. June, 11-13, 2010. Materials . St. Petersburg 2010; p. 145 – 147.
[20]	Blagodatsky M.V. Some facts on pathogenesis of caudogenic ambulant lameness syndrome. Neurology and psychiatry journal. 1982; 82: 4: 52 -57.
[21]	Ramos A. Lumbar disc herniation: CT imagingassessment and clinical outcome. Eur Radiol 1999; 29 - 36.
[22]	Cottone S. Relation of C-reactive protein to oxidative stress and endothelial disfunction in еssеntial hypertension. Hypertension 2005; 23: 2: 58 - 65.
[23]	Torzewski M., Rist C., Mortensen R.F., et al. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in aterogenesis/ Atheroscler Thromb Vase Biol 2000; 20: 2094 – 2099.
[24]	Maksimowicz – McKinnon K., Bhatt D.L., Calabrese L.H. Recent advances in vascular inflammation: C – reactive protein and other inflammatory biomarkers. Curr Opin Rheum 2004; 16: 18 – 24.
[25]	Jiang A., Wang J., Joshi M., Christoforidis J.B. Systemic Treatments for Noninfectious Vitreous Inflammation. Mediators of Inflammation 2013; Article ID 515312, 11 p.
[26]	Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. Journal of Clinical Investigation 2005; 115: 1111.
[27]	Dinarello C.A. Interleukin-1beta and the autoinflammatory diseases. N Engl J Med. 2009; 360: 23: 2467–2470.
[28]	Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev. Immunol. 2009; 27: 519–550.
[29]	Kastner D.L., Aksentijevich I., Goldbach-Mansky R. Autoinflammatory Disease Reloaded: A Clinical Perspective Cell 2010; 140: 6: 784-790.
[30]	Rich S., McLaughlin V.V. Endothelial receptors blockers in cardiovascular disease. Circulation 2003; 108: 2184 – 2190.
[31]	Fornoni A., Raij L. Metabolic syndrome and endothelial dysfunction. Current Hypertension Reports 2005; 7: 88 - 95.
[32]	Oliveira G.H. Novel serologic markers of cardiovascular risk. Current Atherosclerosis Reports 2005; 7: 148 – 154.
[33]	Rich S., . McLaughlin V.V. Endothelial receptors blockers in cardiovascular disease. Circulation 2003; 108: 2184 – 2190.
[34]	Teerlink J.R. Endothelins: Pathophysiology and treatment implications in chronic heart failure. Current Heart Failure Reports 2005; 2: 191 – 197.
[35]	Malik I., Danesh J., Whincup P. et.al. Soluble adhesion molecules andprediction of coronary heart disease: a prospective study and meta-аnalysis. Lancet 2001; 358 : 971 – 976.
[36]	Pasceri V., Willerson J. T., Yeh E.T.H. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102 : 2165 – 2168.

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APA Style

Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. (2014). Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Advances in Biochemistry, 2(6), 95-102. https://doi.org/10.11648/j.ab.20140206.13

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ACS Style

Marina Goryacheva; Grigori Shumakher; Liliya Kostyuchenko; Larisa Tsybirova; Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv. Biochem. 2014, 2(6), 95-102. doi: 10.11648/j.ab.20140206.13

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AMA Style

Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv Biochem. 2014;2(6):95-102. doi: 10.11648/j.ab.20140206.13

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@article{10.11648/j.ab.20140206.13,
  author = {Marina Goryacheva and Grigori Shumakher and Liliya Kostyuchenko and Larisa Tsybirova and Peter Veselovsky and Sergey Fedyanin and Alexey Malikov and Oleg Komarov and Andrey Belousov and Maria Bondareva and Ksenia Goryacheva},
  title = {Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase},
  journal = {Advances in Biochemistry},
  volume = {2},
  number = {6},
  pages = {95-102},
  doi = {10.11648/j.ab.20140206.13},
  url = {https://doi.org/10.11648/j.ab.20140206.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140206.13},
  abstract = {The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.},
 year = {2014}
}

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TY  - JOUR
T1  - Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase
AU  - Marina Goryacheva
AU  - Grigori Shumakher
AU  - Liliya Kostyuchenko
AU  - Larisa Tsybirova
AU  - Peter Veselovsky
AU  - Sergey Fedyanin
AU  - Alexey Malikov
AU  - Oleg Komarov
AU  - Andrey Belousov
AU  - Maria Bondareva
AU  - Ksenia Goryacheva
Y1  - 2014/12/19
PY  - 2014
N1  - https://doi.org/10.11648/j.ab.20140206.13
DO  - 10.11648/j.ab.20140206.13
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 95
EP  - 102
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20140206.13
AB  - The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.
VL  - 2
IS  - 6
ER  -

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Author Information

Marina Goryacheva

Chair of Biology of Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia; Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Grigori Shumakher

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Liliya Kostyuchenko

Chair of Therapy delivering the course of Immunology at Altai State University of RF Public Health Care Ministry, Barnaul, Russia
Larisa Tsybirova

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Peter Veselovsky

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Sergey Fedyanin

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Alexey Malikov

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Oleg Komarov

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Andrey Belousov

Central Scientific-Research Laboratory at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Maria Bondareva

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia
Ksenia Goryacheva

Chair of Nervous Diseases delivering the course of neurology with the framework of Refresher Courses and Continuing Education of Specialists at Altai State Medical University of RF Public Health Care Ministry, Barnaul, Russia

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APA Style

Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. (2014). Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Advances in Biochemistry, 2(6), 95-102. https://doi.org/10.11648/j.ab.20140206.13

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ACS Style

Marina Goryacheva; Grigori Shumakher; Liliya Kostyuchenko; Larisa Tsybirova; Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv. Biochem. 2014, 2(6), 95-102. doi: 10.11648/j.ab.20140206.13

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AMA Style

Marina Goryacheva, Grigori Shumakher, Liliya Kostyuchenko, Larisa Tsybirova, Peter Veselovsky, et al. Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase. Adv Biochem. 2014;2(6):95-102. doi: 10.11648/j.ab.20140206.13

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@article{10.11648/j.ab.20140206.13,
  author = {Marina Goryacheva and Grigori Shumakher and Liliya Kostyuchenko and Larisa Tsybirova and Peter Veselovsky and Sergey Fedyanin and Alexey Malikov and Oleg Komarov and Andrey Belousov and Maria Bondareva and Ksenia Goryacheva},
  title = {Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase},
  journal = {Advances in Biochemistry},
  volume = {2},
  number = {6},
  pages = {95-102},
  doi = {10.11648/j.ab.20140206.13},
  url = {https://doi.org/10.11648/j.ab.20140206.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140206.13},
  abstract = {The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.},
 year = {2014}
}

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TY  - JOUR
T1  - Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase
AU  - Marina Goryacheva
AU  - Grigori Shumakher
AU  - Liliya Kostyuchenko
AU  - Larisa Tsybirova
AU  - Peter Veselovsky
AU  - Sergey Fedyanin
AU  - Alexey Malikov
AU  - Oleg Komarov
AU  - Andrey Belousov
AU  - Maria Bondareva
AU  - Ksenia Goryacheva
Y1  - 2014/12/19
PY  - 2014
N1  - https://doi.org/10.11648/j.ab.20140206.13
DO  - 10.11648/j.ab.20140206.13
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 95
EP  - 102
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20140206.13
AB  - The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase  of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.
VL  - 2
IS  - 6
ER  -

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