2-(2-(Tert-Butoxycarbonyl) Propanamido) Acetic Acid ‘NCA-AG’ Synthesis, Characterization and Reaction Optimization for the Preparation
Advances in Biochemistry
Volume 3, Issue 6, December 2015, Pages: 72-76
Received: Oct. 6, 2015; Accepted: Oct. 23, 2015; Published: Nov. 10, 2015
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Authors
Estella Judith Salamula, Department of Chemistry, Institute of Polymer Science Stellenbosch University, Stellenbosch, South Africa; Department of Chemistry, College of Maths and Science, Makerere University, Kampala, Uganda
Martin Bredenkamp, Department of Chemistry, Asia International Pacific University, Muak Lek Subdistrict, Saraburi Province, Bangkok, Thailand
Deon Bezuidenhout, University of Cape Town, Western Cape, Biomaterial Sciences Laboratories at the Cardiovascular Research Unit (CRU), Cape Town, South Africa
Misael Silas Nadiye-Tabbiruka, Department of Chemistry, University of Botswana, Gabarone, Botswana
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Abstract
2-(2-(tert-butoxycarbonyl) propanamido) acetic acid (NCA-AG) was for the first time prepared using a variation of the Leuchs method. All compounds were characterized using melting point, nuclear magnetic resonance (NMR), ultra violet spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR) and electron spray mass spectroscopy (ESMS). The reaction was optimised to obtain the highest yield by varying the reaction conditions namely; solvent, lewis acid and temperature.
Keywords
2-(2-(Tert-Butoxycarbonyl) Propanamido) Acetic Acid (NCA-AG), Stereospecific Peptides, Synthetic Silk Substrates, N-Tert-Butoxy Carbonanhydride (NCA)
To cite this article
Estella Judith Salamula, Martin Bredenkamp, Deon Bezuidenhout, Misael Silas Nadiye-Tabbiruka, 2-(2-(Tert-Butoxycarbonyl) Propanamido) Acetic Acid ‘NCA-AG’ Synthesis, Characterization and Reaction Optimization for the Preparation, Advances in Biochemistry. Vol. 3, No. 6, 2015, pp. 72-76. doi: 10.11648/j.ab.20150306.12
Copyright
Copyright © 2015 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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