Electrolyte Level Changes in Acute Myocardial Infarction Patients as Compared to Healthy Individuals in Khan Younis Governorate, Gaza Strip
Advances in Biochemistry
Volume 4, Issue 2, April 2016, Pages: 9-15
Received: Mar. 8, 2016;
Accepted: Mar. 16, 2016;
Published: Apr. 5, 2016
Views 8441 Downloads 323
Lamia Fasail Abu Marzoq, Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine
Wafaa Hamad Jaber, Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine
Dina K. Halaid Azzam, Medical Sciences Department, University College of Science and Technology, Gaza Strip, Palestine
Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality across the world. Serum electrolytes changes in AMI have not been studied in Khan Younis Governorate-Palestine. Hence, this study was undertaken to investigate any changes in the serum electrolytes with special attention to serum sodium, potassium, calcium, magnesium and chloride in cases of AMI. Aim: To determine the pattern of changes of serum electrolytes AMI patients and then compare with non AMI (i.e. healthy persons). Materials and Method: The study consisted of a hundred people divided equally into study group and control group. Samples were taken from the Central Heart Unit in Nasser Hospital - Khan Younis. The study group comprised cases of confirmed diagnosis of recent onset of AMI. Clinical data was collected using interviewing questionnaires. The first paragraph of the questionnaire was for personal data which included age, sex and education level. The blood samples of both groups were automatically analyzed for serum electrolytes (Na+, K+, Cl-, Ca+ and Mg+) where the latter was analyzed manually. The cases were taken from AMI patients within 48 hours of admission. Results: The mean of age of controls was 47.18±64 while that of cases was 56.34±12.84. Significant low level of calcium was found in AMI patients while the level observed for magnesium was high. The levels of potassium and magnesium in AMI patients with hypertension was observed to be low with p-value < 0.05. Moreover, potassium levels were also low in AMI patients with diabetes with p-value <0.05. The changesin electrolytes werenot statistically significant in association with smoking. Conclusion: The decrease in sodium level was observed only in patients with AMI compared with healthy persons.
Lamia Fasail Abu Marzoq,
Wafaa Hamad Jaber,
Dina K. Halaid Azzam,
Electrolyte Level Changes in Acute Myocardial Infarction Patients as Compared to Healthy Individuals in Khan Younis Governorate, Gaza Strip, Advances in Biochemistry.
Vol. 4, No. 2,
2016, pp. 9-15.
Alexander Goldberg, Haim Hammerman, Sirouch Petcherski, Alexander Zdorovyak, Sergey Yalonetsky, Michael Kapeliovich, Walter Markiewicz, Doron Aronson (2004).
Amrita Vamne, Swati Pathak, Ramesh Chandra Thanna, Rekha Choudhary, (2015), Index Medical College Hospital & Research Centre, Indore, M. P., India.
Aziz F, Doddi S, Penupolu S, Del Castillo D, Raza W and Kallu S (2011).
P. Kiranmai, N. V. Lakshmi (2014) Comparative Study of Serum Magnesium, Calcium, Potassium and Sodium Levels in Diabetics and Hypertensives with Acute Myocardial Infarction.
Esha Mati, Krishnamurthy N, Ashakiran S, Sumathi M E, Raghavendra Prasad (2012) Departments of Biochemistry, Medicine, Sri Devaraj Urs Medical College, Kolar.
Goldberg A, Hammerman H, Petcherski S, Zdorovyak A Yalonetsky S and Kapeliovich M (2004). The American Journal of Medicine 2004; 117(4): 242-248.
Hadeel Rashid Faraj (2015) Clinical study of some electrolytes (sodium, chloride and potassium) with patients in acute coronary syndrome (ACS) ISSN: 2319-7706.
Jan Erik Nordrehaug (1985) Malignant arrhythmia in relation to serum potassium in acute myocardial infarction.
Jeldsen K K. (2010) Hypokalemia and sudden cardiac death, Exp Clin Cardiol.
Krishnamurthy N, Ashakiran S, Sumathi M E, Raghavendra (2012). Prasad 1Departments of Biochemistry, Medicine, Sri Devaraj Urs Medical College, Kolar.
Lehmann G, Deisenhofer I, Ndrepepa G, Schmitt C. (2000). ECG changes in a 25- year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemi mimicking acute myocardial infarction. Chest 2000; 118 (1).
Mac Donald J E, Struthers A D. (2014) Cardio 2004; 43(2):155-161.
Maciejewski P, Bednarz B, Chamiec T, Górecki A, Łukaszewicz R, Ceremuzynski L. (2003 Nov). Acute coronary syndrome: potassium, magnesium and cardiac .arrhythmia. Kardiol Pol; 59(11).
Munesh Tomar, Sitaraman Radhakrishnan And Savitri Shrivastava (2008).
Myoishi M, Kitakaze M. (2005 Feb) A role of magnesium: magnesium in the therapy for cardiovascular diseases. Clin Calcium.; 15(2): 265–270.
Opie LH. Mechanisms of cardiac contraction and relaxation. In: Braunwald E (ed). Heart disease: a textbook of cardiovascular medicine. WB Saunders, Philadelphia, 1996.
Prognostic Implication of Hyponatremia in Setting of Myocardial Infarction. Chest 1; 140(4 Meeting Abstracts): 986A–986A.
Rasmussen HS. (1988) Justification for intravenous magnesium therapy in acute myocardial infarction. Magnes Res; 1(1-2): 59–73.
Ramesh Ramasamy, Sathish Babumurugaiyan, Niranjan Gopal, Rachel Shalini (2013) Institute Pillayarkuppam Puducherry - 605 402, India
Shaikh S, Karira KA (2011), Magnesium deficiency in heart failure patients withdiabetes mellitus. J Pak Med Assoc; 61(9)
Tada Y, Nakamura T, Funayama H, Sugawara Y, Ako J, Ishikawa S, Momomura S.(2011), Early development of hyponatremia implicates short and long term outcomes in ST elevation acute myocardial infarction. Circ J 2011; 75: 1927-1933.
Taysir S Garadah, Salah Kassab, Jamal Golbahar, Bahrain Med Bull 2011; 33(1).
Vinod Wali and Singi Yatiraj. (2014) Study of Serum Sodium and Potassium in Acute Myocardial Infarction. DOI: 10.7860/JCDR.
Xianghua F, Peng Q, Yanbo W, Shigiang L, Weize F, Yunfa J.(2010(The relationship between hypokalemia at the early stage of acute myocardial infarction and malignant ventricular arrhythmia; Heart 96: 196.