Since it has been shown that Alzheimer’s disease is accompanied by higher peripheral concentrations of cytokines, we focused on the correction of chronic inflammation causing Aβ excess and aggregation what should have a positive impact. Proinflammatory cytokines action is realized by NF-κB intracellular signals. Curcumin can inhibit activation of the proinflammatory transcription factor NF-κB and is able to be mounted in the amyloid-β fibrils and encourage their disaggregation. To study the influence of anti-inflammatory effect of curcumin and its ability to model complexes with a fragment of AβPP. Investigation was carried out on rats with model of Alzheimer’s disease using nasal therapy with curcumin Concentration of cytokines in cerebral cortex, hippocampus and blood serum, and indicators of conditioned active escape reflex were determined in this study. Methods of molecular dynamics and docking were used to examine the interactions of curcumin with fragment of AβPP. Аβ42_Human in the hippocampus of rats provoked chronic neuroinflammation specifically and primarily at the injection site. Curcumin performance revealed specific depressing effect on cytokines in the cerebral cortex and in the hippocampus it appeared similar to the above, but of lower level. Anti-inflammatory activity of curcumin led to the recovery of memory parameters. Analysis of restriction sites of AβPP has shown that position of curcumin in Site II is energetically more favorable for binding. Our suggestion that curcumin is an effective anti-cytokine factor was confirmed by experimental results obtained in vivo and explain the mechanism describing its effect on NF-κB Curcumin doesn’t block the excision Aβ but binding with its hydrophobic region.
| Published in | Advances in Biochemistry (Volume 4, Issue 4) |
| DOI | 10.11648/j.ab.20160404.11 |
| Page(s) | 34-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Alzheimer's Disease, Curcumin, Amyloid-β, Cytokine, Rat, Docking
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APA Style
Victoria V. Sokolik, Pavel A. Karpov, Dariya A. Samofalova, Sergiy M. Shulga. (2016). Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP. Advances in Biochemistry, 4(4), 34-46. https://doi.org/10.11648/j.ab.20160404.11
ACS Style
Victoria V. Sokolik; Pavel A. Karpov; Dariya A. Samofalova; Sergiy M. Shulga. Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP. Adv. Biochem. 2016, 4(4), 34-46. doi: 10.11648/j.ab.20160404.11
AMA Style
Victoria V. Sokolik, Pavel A. Karpov, Dariya A. Samofalova, Sergiy M. Shulga. Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP. Adv Biochem. 2016;4(4):34-46. doi: 10.11648/j.ab.20160404.11
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Download@article{10.11648/j.ab.20160404.11,
author = {Victoria V. Sokolik and Pavel A. Karpov and Dariya A. Samofalova and Sergiy M. Shulga},
title = {Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP},
journal = {Advances in Biochemistry},
volume = {4},
number = {4},
pages = {34-46},
doi = {10.11648/j.ab.20160404.11},
url = {https://doi.org/10.11648/j.ab.20160404.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20160404.11},
abstract = {Since it has been shown that Alzheimer’s disease is accompanied by higher peripheral concentrations of cytokines, we focused on the correction of chronic inflammation causing Aβ excess and aggregation what should have a positive impact. Proinflammatory cytokines action is realized by NF-κB intracellular signals. Curcumin can inhibit activation of the proinflammatory transcription factor NF-κB and is able to be mounted in the amyloid-β fibrils and encourage their disaggregation. To study the influence of anti-inflammatory effect of curcumin and its ability to model complexes with a fragment of AβPP. Investigation was carried out on rats with model of Alzheimer’s disease using nasal therapy with curcumin Concentration of cytokines in cerebral cortex, hippocampus and blood serum, and indicators of conditioned active escape reflex were determined in this study. Methods of molecular dynamics and docking were used to examine the interactions of curcumin with fragment of AβPP. Аβ42_Human in the hippocampus of rats provoked chronic neuroinflammation specifically and primarily at the injection site. Curcumin performance revealed specific depressing effect on cytokines in the cerebral cortex and in the hippocampus it appeared similar to the above, but of lower level. Anti-inflammatory activity of curcumin led to the recovery of memory parameters. Analysis of restriction sites of AβPP has shown that position of curcumin in Site II is energetically more favorable for binding. Our suggestion that curcumin is an effective anti-cytokine factor was confirmed by experimental results obtained in vivo and explain the mechanism describing its effect on NF-κB Curcumin doesn’t block the excision Aβ but binding with its hydrophobic region.},
year = {2016}
}
TY - JOUR T1 - Anti-Cytokine Activity of Curcumin and Its Binding to a Fragment of AβPP AU - Victoria V. Sokolik AU - Pavel A. Karpov AU - Dariya A. Samofalova AU - Sergiy M. Shulga Y1 - 2016/06/20 PY - 2016 N1 - https://doi.org/10.11648/j.ab.20160404.11 DO - 10.11648/j.ab.20160404.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 34 EP - 46 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20160404.11 AB - Since it has been shown that Alzheimer’s disease is accompanied by higher peripheral concentrations of cytokines, we focused on the correction of chronic inflammation causing Aβ excess and aggregation what should have a positive impact. Proinflammatory cytokines action is realized by NF-κB intracellular signals. Curcumin can inhibit activation of the proinflammatory transcription factor NF-κB and is able to be mounted in the amyloid-β fibrils and encourage their disaggregation. To study the influence of anti-inflammatory effect of curcumin and its ability to model complexes with a fragment of AβPP. Investigation was carried out on rats with model of Alzheimer’s disease using nasal therapy with curcumin Concentration of cytokines in cerebral cortex, hippocampus and blood serum, and indicators of conditioned active escape reflex were determined in this study. Methods of molecular dynamics and docking were used to examine the interactions of curcumin with fragment of AβPP. Аβ42_Human in the hippocampus of rats provoked chronic neuroinflammation specifically and primarily at the injection site. Curcumin performance revealed specific depressing effect on cytokines in the cerebral cortex and in the hippocampus it appeared similar to the above, but of lower level. Anti-inflammatory activity of curcumin led to the recovery of memory parameters. Analysis of restriction sites of AβPP has shown that position of curcumin in Site II is energetically more favorable for binding. Our suggestion that curcumin is an effective anti-cytokine factor was confirmed by experimental results obtained in vivo and explain the mechanism describing its effect on NF-κB Curcumin doesn’t block the excision Aβ but binding with its hydrophobic region. VL - 4 IS - 4 ER -
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