Advances in Biochemistry

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Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

Received: 28 August 2016    Accepted: 05 September 2016    Published: 18 October 2016
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Abstract

The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.

DOI 10.11648/j.ab.20160405.12
Published in Advances in Biochemistry (Volume 4, Issue 5, October 2016)
Page(s) 58-65
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Atropine, Permanganate, Oxidation, Kinetics, Mechanism

References
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Author Information
  • Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia; Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt

  • Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia

  • Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia

  • Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia

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    Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. (2016). Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Advances in Biochemistry, 4(5), 58-65. https://doi.org/10.11648/j.ab.20160405.12

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    Ahmed Fawzy; Ishaq A. Zaafarany; Fahd A. Tirkistani; Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv. Biochem. 2016, 4(5), 58-65. doi: 10.11648/j.ab.20160405.12

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    AMA Style

    Ahmed Fawzy, Ishaq A. Zaafarany, Fahd A. Tirkistani, Basim H. Asghar. Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study. Adv Biochem. 2016;4(5):58-65. doi: 10.11648/j.ab.20160405.12

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  • @article{10.11648/j.ab.20160405.12,
      author = {Ahmed Fawzy and Ishaq A. Zaafarany and Fahd A. Tirkistani and Basim H. Asghar},
      title = {Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study},
      journal = {Advances in Biochemistry},
      volume = {4},
      number = {5},
      pages = {58-65},
      doi = {10.11648/j.ab.20160405.12},
      url = {https://doi.org/10.11648/j.ab.20160405.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ab.20160405.12},
      abstract = {The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study
    AU  - Ahmed Fawzy
    AU  - Ishaq A. Zaafarany
    AU  - Fahd A. Tirkistani
    AU  - Basim H. Asghar
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    DO  - 10.11648/j.ab.20160405.12
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    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
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    EP  - 65
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20160405.12
    AB  - The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.
    VL  - 4
    IS  - 5
    ER  - 

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