Evaluation of Hepatoprotective Activities Aqueous and Hydroethanolic Extracts from the Leaves of Erythrococca anomala in Rats
Advances in Biochemistry
Volume 5, Issue 4, August 2017, Pages: 61-66
Received: May 18, 2017; Accepted: May 31, 2017; Published: Jul. 13, 2017
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Authors
Miezan Bile Aka Patrice, Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
Kouakou Sylvain Landry, Department of Pharmacology, Clinical and Therapeutic Pharmacy UFR Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
Droucoula Guillaume Cyril, Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
Kouakou-Syransy Giselle, Department of Pharmacology, Clinical and Therapeutic Pharmacy UFR Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
Koffi Akissi Jeanne, Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
Yapi Houphouet Felix, Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphouet Boigny University, Abidjan, Ivory Coast
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Abstract
Widely used in Ivory Coast and sub-Saharan Africa in traditional medicine as anti-inflammatory, antioxidant, laxative and purgative, Erythrococca anomala (Euphorbiaceae), is an annual plant. In this work, the aim was to evaluate the Hepatoprotective activity of the aqueous and hydroethanolic extracts of the leaves. Carbon Tetrachloride (CCl4) was used to induce hepatotoxicity in rats. This hepatotoxic effect causes a significant increase in the levels of liver enzymes and serum proteins. Hepatoprotective activity was assessed by assaying liver enzymes such as serum transaminases (alanine aminotransferase and aspartate aminotransferase) and proteins by spectrophotometric and electrophoretic techniques. When administered orally as a preventive and curative dose of 100 and 200 mg / kg body weight, the extracts significantly reduce significantly as silymarin, the reference hepatoprotective substance at 100 mg / kg bw, hepatotoxicity induced by Carbon tetrachloride (CCL4) at a dose of 5 mg / kg bw after a significant reduction in liver enzyme levels, globulins and a significant increase in albumin. The possible mechanism of this hepatoprotective activity of the extracts may be due to the action of the antioxidants such as the flavonoids, the phenols present in the extracts.
Keywords
Erythrococca anomala, Silymarin, Carbon Tetrachloride, Hepatotoxicity, Hepatoprotective
To cite this article
Miezan Bile Aka Patrice, Kouakou Sylvain Landry, Droucoula Guillaume Cyril, Kouakou-Syransy Giselle, Koffi Akissi Jeanne, Yapi Houphouet Felix, Evaluation of Hepatoprotective Activities Aqueous and Hydroethanolic Extracts from the Leaves of Erythrococca anomala in Rats, Advances in Biochemistry. Vol. 5, No. 4, 2017, pp. 61-66. doi: 10.11648/j.ab.20170504.12
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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