Hydrophylic Polyurethaneurea Containing the Copolymer of N-vinylpyrrolidone, Vinyl Acetate and Vinyl Alcohol for Possible Biomedical Use
Advances in Biochemistry
Volume 5, Issue 4, August 2017, Pages: 73-78
Received: May 30, 2017;
Accepted: Jun. 26, 2017;
Published: Jul. 31, 2017
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Tetiana Rudenchyk, Institute of Macromolecular Chemistry of NAS of Ukraine, Kyiv, Ukraine
Rita Rozhnova, Institute of Macromolecular Chemistry of NAS of Ukraine, Kyiv, Ukraine
Nataliia Galatenko, Institute of Macromolecular Chemistry of NAS of Ukraine, Kyiv, Ukraine
The series of polyurethaneurea (PUU) containing in its structure the fragments of the copolymer of N-vinylpyrrolidone, vinyl acetate and vinyl alcohol (VP-VA) with the 1.6-hexamethylenediamine (HMDA) macrochain extender and the series of PUU with the 4.4'-diaminodiphenylmethane (DADPh) macrochain extender having different ratio of HMDA and DADPh to VP-VA (30:70; 40:60; 50:50; 60:40; 70:30) were synthesized. It has been established that PUU containing in its structure the DADPh macrochain extender is characterized by higher values of the tensile strength and relative elongation at break, glass-transition temperature and the change of the specific heat capacity and hydrophilicity compared to PUU containing in its structure the HMDA macrochain extender. It was found that the increase in amount of VP-VA copolymers in PUU structure increases hydrophilicity by 19-41% for PUU with HMDA and by 16-62% for PUU with DADPh and will contribute to a prolonged release of biologically active substances from the polymer matrix. The results obtained allowed us to determine that the PUU with VP-VA copolymer fragments in the structure synthesized with the ratio of HMDA and DADPh to VP-VA 70:30 is characterized by sufficient physical-mechanical properties (σ = 3.1 MPa, ε = 47% and σ = 5.2 MPa, ε = 90%, accordingly), hydrophilicity (21.0% and 19.4%, accordingly) and can be used as a polymer matrix for medicine biologically active composite materials.
Hydrophylic Polyurethaneurea Containing the Copolymer of N-vinylpyrrolidone, Vinyl Acetate and Vinyl Alcohol for Possible Biomedical Use, Advances in Biochemistry.
Vol. 5, No. 4,
2017, pp. 73-78.
Xiangyu Liu, Yuqing Niu, Kevin C. Chen, Shiguo Chen. “Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing”, Materials Science and Engineering: C, 2017, Vol. 71, pp. 289-297.
J. A. Braatz, C. L. Kehr. Pat. 4886866 USA, C 08G 18/10. “Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers”, No. 312.331; appl. 16.02.1989; publ. 12.12.1989.
A. Burke, N. Hasirci “Polyurethanes in Biomedical Applications”, Advances in Experimental Medicine and Biology, 2004, V. 553, pp. 83–101.
P. C. Caracciolo, A. A. A. de Queiroz, O. Z. Higa, F. Buffa, G. A. Abraham. “Segmented poly (esterurethane urea) s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties”, Acta Biomaterialia, Vol. 4, № 4, 2008, pp. 976–988.
Y. Hong, J. Guan, K. L. Fujimoto [et al.] “Tailoring the degradation kinetics of poly (ester carbonate urethane) urea thermoplastic elastomers for tissue engineering scaffolds”, Biomaterials, 2010, V. 31, № 15, pp. 4249–4258.
A. Kondyurin, V. Romanova, V. Begishev [et al.] “Crosslincked polyurethane coating on vascular stents for enhanced x-ray contrast”, Journal of Bioactive and Compatible Polymers, 2005, V. 20, pp. 77–93.
M. Niaounakis Biopolymers: Applications and Trends. Waltham : Elsevier, 2015.
M. R. Gallego, J. V. A. Vange Pat. 2013178229 WO, D 04 H 1/728, A 61 L 31/14, D 04H 3/04. “Biodegradable non-woven mesh with gluepoints”, applicant and patent holder COLOPLAST A/S. – № DK 2013/050162; filed. 29.05.13 ; publ. 05.12.2013.
M. Zieleniewska, M. Auguscik, A. Prociak, P. Rojek, J. Ryszkowska “Polyurethane-urea substrates from rapeseed oil-based polyol for bone tissue cultures intended for application in tissue engineering”, Polymer Degradation and Stability, 2014, Vol. 108, pp. 241-249.
Katherine D. Kavlock, Todd W. Pechar, Jeffrey O. Hollinger, Scott A. Guelcher, Aaron S. Goldstein “Synthesis and characterization of segmented poly (esterurethane urea) elastomers for bone tissue engineering”, Acta Biomaterialia, 2007, Vol. 3, № 4, pp. 475-484.
Tonghe Zhu, Kui Yu, M. Aqeel Bhutto, Xuran Guo, Wei Shen, Juan Wang, Weiming Chen, Hany El-Hamshary, Salem S. Al-Deyab, Xiumei Mo “Synthesis of RGD-peptide modified poly (ester-urethane) urea electrospun nanofibers as a potential application for vascular tissue engineering”, Chemical Engineering Journal, 2017, Vol. 315, pp 177–190.
L. M. Mazur, R. A. Rozhnova, V. I. Drozdova, N. A. Galatenko. “The Synthesis of the New Drug Form with Amizonum Based on Hydrophilic Block-copolyurethane Containing the Copolymer of N-vinylpyrrolidone and Vinyl Alcohol”, Polymer journal, 2007, Vol. 29, № 1, pp. 58-66.
R. A. Rozhnova, O. S. Karpenko, T. V. Rudenchik et al. “Synthesis film materials with decamethoxine on the basis of polyurethaneureas, which containing in its structure fragments of the copolymer of N-vinylpyrrolidone with vinyl alcohol” (in Ukrainian), Scientific Papers NaUKMa, 2016, Vol. 183, pp. 54-59.
N. A. Galatenko, R. A. Rozhnova, O. S. Andryushina Pat. 55891 UA, С 08G 71/00; С 07D 475/00; А 61L 31/00. “Diaminе-containing polyurethaneureas with folic acid as polymer film biologically active materials medical purpose”, № u201008173; appl. 30.06.10; publ. 27.12.10.
E. Pretsch, P. Bёllmann, C. Affolter Structure determination of organic compounds. Tables of Spectral Data. Springer-Verlag Berlin Heidelberg New York. 2000.