Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq
Advances in Biochemistry
Volume 5, Issue 5, October 2017, Pages: 79-88
Received: Aug. 12, 2017; Accepted: Aug. 28, 2017; Published: Sep. 12, 2017
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Adnan Jassim Mohammed Al-Fartosy, Department of Chemistry, College of Science, University of Basra, Basra, Iraq
Ibrahim Majar Mohammed, Department of Chemistry, College of Science, University of Basra, Basra, Iraq
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Obesity, a case accompanied by increased insulin resistance, is associated with low follicle stimulating hormone, luteinizing hormone, total testosterone and progesterone and estradiol levels. As there is no scientific report on diabetes complications and its effects on type 2 diabetic patients in the province of Meisan (southern of Iraq), the present investigation was done to evaluate the levels of body mass index, insulin resistance and the levels of sex hormones in serum of both men and women type 2 diabetic patients. Data obtained in the present study, show a significant increase in insulin resistance level (4.24 ± 0.57 Vs. 1.36±0.23 and 4.31 ± 0.59 Vs. 1.18 ±0.13, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. Also, the present study show a significant decrease in follicle stimulating hormone level (7.24±1.14 Vs. 12.79 ±0.87 and 38.14 ± 4.44 Vs. 54.16 ± 3.64, P < 0.05), a significant decrease in luteinizing hormone level (5.32 ± 0.74 Vs. 7.54± 1.27 and 30.12 ± 4.20 Vs. 43.33±2.07, P < 0.05), a significant decrease in testosterone level (4.69 ± 0.92 Vs. 8.20 ± 2.2 and 0.57 ± 0.11 Vs. 0.69± 0.21, P < 0.01), a significant decrease in progesterone level (0.25 ±0.03 Vs. 0.42 ± 0.10 and 0.30 ± 0.04 Vs. 0.46± 0.12, P < 0.05) and a significant decrease in estradiol level (25.04 ± 3.35 Vs. 33.80±8.4 and 34.33 ± 4.21 Vs. 41.42±5.64, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. In conclusion, the findings further demonstrated that insulin resistance plays an important role in the pathogenesis of many human diseases, such as diabetes, obesity, and reduction of fertility. Therefore, the associated of obesity and increased insulin resistance is accompanied by low levels of follicle stimulating hormone, luteinizing hormone, testosterone, progesterone and estradiol in both men and women.
Insulin Resistance, Obesity, Sex Hormones, Type 2 Diabetes Mellitus
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Adnan Jassim Mohammed Al-Fartosy, Ibrahim Majar Mohammed, Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq, Advances in Biochemistry. Vol. 5, No. 5, 2017, pp. 79-88. doi: 10.11648/j.ab.20170505.11
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