Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia
Advances in Biochemistry
Volume 6, Issue 2, April 2018, Pages: 10-18
Received: Mar. 24, 2018; Accepted: May 19, 2018; Published: Jun. 11, 2018
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Alias Tesfamariam, Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Menakath Menon, Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Tedla Kebede, Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia
Solomon Genet, Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
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Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.
Type-2 Diabetes, Lipid Profile, Renal Function Test, Incretin-Based Therapy, BMI
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Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet, Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia, Advances in Biochemistry. Vol. 6, No. 2, 2018, pp. 10-18. doi: 10.11648/j.ab.20180602.11
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