Advances in Biochemistry

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Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes

Received: 17 February 2019    Accepted: 08 April 2019    Published: 29 April 2019
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Abstract

The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.

DOI 10.11648/j.ab.20180606.11
Published in Advances in Biochemistry (Volume 6, Issue 6, December 2018)
Page(s) 47-52
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Stroke, Polymorphism of the Haptoglobin Gene, Lipid Balance

References
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[5] Diouf Basse A. M., Ndao A. K., Ndiaye M., Touré K., Thiam A., Ndiaye M. M., Diop A. G., Ndiaye I. P.« Pronostic fonctionnel des accidents vasculaires cérébraux dans les pays en voie de développement: Sénégal». Annales de Réadaptation et de Médecine Physique 2006; 49 (3): 100‑104.
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[11] Holme I., Aastveit A. H., Hammar N., Jungner I., Walldius G. «Haptoglobin and Risk of Myocardial Infarction, Stroke, and Congestive Heart Failure in 342,125 Men and Women in the Apolipoprotein MOrtality RISk Study (AMORIS)». Annals of Medicine 2009; 41 (7): 522‑32.
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[20] Cisse O., Lemine D. S. M., Ba F., Ba E. H. M., Diop M. S., Diagne N. S., Sow A. D., Basse A. M., Touré K., Ndiaye M., Diop G. A., Ndiaye M. M. «Le profil lipidique et glucidique des accidents vasculaires cérébraux ischémiques à Dakar». The Pan African Medical Journal 2016;25.
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Author Information
  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal

  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Department of Medical Biochemistry, Saint-Louis University, Saint-Louis, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

  • Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal; Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal

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  • APA Style

    Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. (2019). Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Advances in Biochemistry, 6(6), 47-52. https://doi.org/10.11648/j.ab.20180606.11

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    ACS Style

    Moustapha Djite; Néné Oumou Kesso Barry; Jean Pascal Demba Diop; Fatoumata Binta Bah; Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv. Biochem. 2019, 6(6), 47-52. doi: 10.11648/j.ab.20180606.11

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    AMA Style

    Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv Biochem. 2019;6(6):47-52. doi: 10.11648/j.ab.20180606.11

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  • @article{10.11648/j.ab.20180606.11,
      author = {Moustapha Djite and Néné Oumou Kesso Barry and Jean Pascal Demba Diop and Fatoumata Binta Bah and Pape Matar Kandji and El Hadji Malick Ndour and Fatou Gueye-tall and Dominique Doupa and Rokhaya Ndiaye diallo and Philomène Lopez Sall and Aynina Cisse and Pape Amadou Diop and Papa Madièye Gueye},
      title = {Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes},
      journal = {Advances in Biochemistry},
      volume = {6},
      number = {6},
      pages = {47-52},
      doi = {10.11648/j.ab.20180606.11},
      url = {https://doi.org/10.11648/j.ab.20180606.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ab.20180606.11},
      abstract = {The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes
    AU  - Moustapha Djite
    AU  - Néné Oumou Kesso Barry
    AU  - Jean Pascal Demba Diop
    AU  - Fatoumata Binta Bah
    AU  - Pape Matar Kandji
    AU  - El Hadji Malick Ndour
    AU  - Fatou Gueye-tall
    AU  - Dominique Doupa
    AU  - Rokhaya Ndiaye diallo
    AU  - Philomène Lopez Sall
    AU  - Aynina Cisse
    AU  - Pape Amadou Diop
    AU  - Papa Madièye Gueye
    Y1  - 2019/04/29
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ab.20180606.11
    DO  - 10.11648/j.ab.20180606.11
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 47
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20180606.11
    AB  - The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.
    VL  - 6
    IS  - 6
    ER  - 

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