Prevalence and Factors Associated with Dyslipidemia in Adults with Sickle Cell Disease in Parakou (Benin)
Advances in Biochemistry
Volume 8, Issue 1, March 2020, Pages: 11-15
Received: Dec. 21, 2019;
Accepted: Dec. 30, 2019;
Published: Jan. 7, 2020
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Moutawakilou Gomina, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Moussa Ayedoun, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Tarik Salifou, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Delphin Aidewou, Borgou Regional Branch of the National Agency for Blood Transfusion, Parakou, Benin
Simon Akpona, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Objective: Determine the prevalence and factors associated with dyslipidemia in adult subjects with sickle cell disease in Parakou in 2017. Methods: This research work was a descriptive, analytical, cross-sectional and observational study carried out from January 6 to June 6, 2017. It involved 100 adult subjects with sickle cell disease (mean age: 28.77 ± 8.73 years) in the city of Parakou (Benin). Serum lipid parameters were measured through enzymatic colorimetric methods on Mindray ® BS-120 automaton (Guangdong, China). The different types of dyslipidemia were classified according to criteria defined in the National Cholesterol Education Program Adult Treatment Panel III. Results: The overall prevalence of the different types of dyslipidemia was estimated at 82% (95% CI [75.27; 88.34]). The different types of dyslipidemia were distributed as followed: HDL hypocholesterolemia (79%; 95%IC [69.71; 86.51]), LDL hypercholesterolemia (13.0%; 95%CI [7.11; 21.20]), total hypercholesterolemia (7.0%; 95%CI [02.86; 13.89]), hypertriglyceridemia (4.0%; 95%CI [1.10; 9.93]) and mixed hyperlipidemia (1.0%; 95%CI [0.03; 5.45]). Atherogenic dyslipidemia was not found out. HDL hypocholesterolemia was significantly associated with personal history of hypertension (P = 0.029), emaciation (P = 0.023) and age above or equal to 50 years (P = 0,016). Tobacco consumption (P = 0.01) and age below 50 years (P = 0.02) were significantly associated with hypertriglyceridemia. Conclusion: The prevalence of the different types of dyslipidemia is high among adults with sickle cell disease in Parakou.
Prevalence and Factors Associated with Dyslipidemia in Adults with Sickle Cell Disease in Parakou (Benin), Advances in Biochemistry.
Vol. 8, No. 1,
2020, pp. 11-15.
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