Prevalence and Factors Associated with Dyslipidemia in Adults with Sickle Cell Disease in Parakou (Benin)
Advances in Biochemistry
Volume 8, Issue 1, March 2020, Pages: 11-15
Received: Dec. 21, 2019;
Accepted: Dec. 30, 2019;
Published: Jan. 7, 2020
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Moutawakilou Gomina, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Moussa Ayedoun, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Tarik Salifou, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Delphin Aidewou, Borgou Regional Branch of the National Agency for Blood Transfusion, Parakou, Benin
Simon Akpona, Unit for Training & Research in Biochemistry, Faculty of Medicine, University of Parakou, Parakou, Benin
Objective: Determine the prevalence and factors associated with dyslipidemia in adult subjects with sickle cell disease in Parakou in 2017. Methods: This research work was a descriptive, analytical, cross-sectional and observational study carried out from January 6 to June 6, 2017. It involved 100 adult subjects with sickle cell disease (mean age: 28.77 ± 8.73 years) in the city of Parakou (Benin). Serum lipid parameters were measured through enzymatic colorimetric methods on Mindray ® BS-120 automaton (Guangdong, China). The different types of dyslipidemia were classified according to criteria defined in the National Cholesterol Education Program Adult Treatment Panel III. Results: The overall prevalence of the different types of dyslipidemia was estimated at 82% (95% CI [75.27; 88.34]). The different types of dyslipidemia were distributed as followed: HDL hypocholesterolemia (79%; 95%IC [69.71; 86.51]), LDL hypercholesterolemia (13.0%; 95%CI [7.11; 21.20]), total hypercholesterolemia (7.0%; 95%CI [02.86; 13.89]), hypertriglyceridemia (4.0%; 95%CI [1.10; 9.93]) and mixed hyperlipidemia (1.0%; 95%CI [0.03; 5.45]). Atherogenic dyslipidemia was not found out. HDL hypocholesterolemia was significantly associated with personal history of hypertension (P = 0.029), emaciation (P = 0.023) and age above or equal to 50 years (P = 0,016). Tobacco consumption (P = 0.01) and age below 50 years (P = 0.02) were significantly associated with hypertriglyceridemia. Conclusion: The prevalence of the different types of dyslipidemia is high among adults with sickle cell disease in Parakou.
Prevalence and Factors Associated with Dyslipidemia in Adults with Sickle Cell Disease in Parakou (Benin), Advances in Biochemistry.
Vol. 8, No. 1,
2020, pp. 11-15.
Zorca S, Freeman L, Hildesheim M, Allen D, Remaley AT, TaylorJG, Kato GJ (2010) Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension. Br J Haematol 149 (3): 436–445. doi: 10.1111/j.1365-2141.2010.08109.x.
Lalanne-Mistrih ML, Connes P, Lamarre Y, Lemonne N, Hardy-Dessources MD, Tarer V, Etienne-Julan M, Mougenel D, Tressières B, Marc Romana M (2018) Lipid profiles in French West Indies sickle cell disease cohorts, and their general Population. Lipids in Health and Disease 17: 38. https://doi.org/10.1186/s12944-018-0689-5.
Agrawal S, Tikariha BP, Khodiar PK (2013) Serum Lipid Profile In Sickle Cell Disease Patients In Raipur District, Chhattisgarh. IJBAP 2 (1): 132-135.
Alsultan AI, Seif MA, Amin TT, Naboli M, Alsuliman AM (2010) Relationship between oxidative stress, ferritin and insulin resistance in sickle cell disease. Eur Rev Med Pharmacol Sci 14: 527-538.
Yesim OE, Suna S, Selma U, Hilal O, Nuriman O (2011) Hypocholesterolemia is associated negatively with hemolysate lipid peroxidation in sickle cell anemia patients. Clin Exp Med 11: 195-198. doi: 10.1007/s10238-010-0124-3.
Magalhães Aleluia M, Conceição da Guarda C, Pereira Santiago R, Teresa Cristina Cardoso Fonseca TC, Idalina Neves F, Quinto de Souza R, Alves Farias L, Araújo Pimenta F, Magalhães Fiuza L, Nogueira Pitanga T, Dutra Ferreira JR, Vitória Adorno E, Veloso Cerqueira BA, de Souza Gonçalves M (2017) Association of classical markers and establishment of the dyslipidemic subphenotype of sickle cell anemia. Lipids in Health and Disease 16: 74. doi: 10.1186/s12944-017-0454-1.
Monnet PD, Kane F, Konan-Waidhet D, Akpona S, Kora J, Diafouka F, Sess D, Sangare A, Yapo AE (1996) Evaluation of atherogenic risk in homozygous sickle cell disease: study of lipid and apolipoprotein AI and B plasma levels. Bull Soc Pathol Exot 89 (4): 278-281.
Monde AA, Kouane-Koutouna A, Tiahou GG, Camara CM, Yapo AA, Djessou SP, Sess ED (2010) Profil lipidoprotéique, isotopique et risque athérogène dans la drépanocytose en Côte d’Ivoire. Med Nucl 34: 17-21. doi: 10.1016/j.mednuc.2010.07.015.
Ould Amar AK, Gibert AP, Darmon O, Besse P, Cenac A, Césaire R (1999) Hémoglobinopathies hétérozygotes AS et risque coronaire. Archives des maladies du cœur et des vaisseaux 92: 1727-1732. French.
Rahimi Z, Merat A, Haghshenass M, Madani H, Rezaei M, Nagel RL (2006) Plasma lipids in Iranians with sickle cell disease: Hypocholesterolemia in sickle cell anemia and increase of HDL-cholesterol in sickle cell trait. Clinica Chimica Acta 365: 217 – 220. doi: 10.1016/j.cca.2005.08.022.
Ephraim RKD, Adu P, Ake E, Agbodzakey H, Adoba P, Cudjoe O, Agoni C (2016) Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids. Article ID 7650530, 5 pages. http://dx.doi.org/10.1155/2016/7650530
Gueye Tall F, Ndour EHM, Cissé F, Gueye PM, Ndiaye Diallo R, Diatta A, Lopez Sall P, Cissé A (2014) Perturbations de paramètres lipidiques au cours de la drépanocytose. Rev. CAMES SANTE 2 (2): 35-41. French.
Shores J, Peterson J, Vander Jagt D, Glew RH (2003) Reduced cholesterol levels in African-American adults with sickle cell disease. J Natl Med Assoc 95: 813–817.
Seixas MO, Rocha LC, Carvalho MB, Menezes JF, Lyra IM, Nascimento VM, Couto RD, Atta AM, Reis MG, Goncalves MS (2010) Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids Health Dis 9: 91. doi: 10.1186/1476-511X-9-91.
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of concentration of lowdensity lipoprotein cholesterol in plasma without use of ultracentrifuge. Clin Chem 18 (6): 499-502.
National Cholesterol Education Program (2002) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106 (25): 3143-421.
McMahon M, Grossman J, FitzGerald J, Dahlin-Lee E, Wallace DJ, Thong BY, Badsha H, Kalunian K, Charles C, Navab M, Fogelman AM, Hahn BH (2006) Proinflammatory high density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 54 (8): 2541–2549. doi: 10.1002/art.21976.
Mineo C, Deguchi H, Griffin JH, Shaul PW (2006) Endothelial and antithrombotic actions of HDL. Circ Res 98: 1352–1364.
Akinlade KS, Adewale CO, Rahamon SK, Fasola FA, Olaniyi JA, Atere AD (2014) Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis. Niger Med J 55 (5): 428-431. doi: 10.4103/0300-1652.140388.
Shalev H, Kapelushnik J, Moser A, Knobler H, Tamary H (2007) Hypocholesterolemia in chronic anemias with increased erythropoietic activity. Am J Hematol 82: 199-202.
Er Oztas Y (2012) Hypocholesterolemia in Sickle Cell Anemia: What is the Reason behind it? Biochem & Pharmacol 1: e110. doi: 10.4172/2167-0501.1000e110µ.
Erasmus RT, Olukoga AO, Ojuawo O (1990) Plasma lipids and lipoproteins in Nigeria children with sickle cell anemia. Ann Trop Paediatr 10: 421-423.
El Hazmi MAF, Warsey AS, Al-Swailem A, Al-Swailem A, Bahakim H (1995) Red cell genetic disorders and plasma lipids. J Trop Paediatr 41: 202–205.
Yuditskaya S, Tumblin A, Hoehn GT, Wang G, Drake SK, Xu X, Ying S, Chi AH, Remaley AT, Shen RF, Munson PJ, Suffredini AF, Kato GJ (2009) Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease. Blood 113: 1122–1128.
Nofer JR, Kehrel B, Fobker M, Levkau B, Assmann G, von Eckardstein A (2002) HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis 161: 1–16.
Bhatkulkar P, Khare R, Meshram AW, Dhok A (2015) Status of Oxidative Stress and Lipid Profile in Patients of Sickle Cell Anemia. IJHSR 5 (3): 189-193.
Mokondjimobe É, Longo-Mbenza B, Ovono-Abessolo F, Gombet T, Guie G, Ngou-Milama E, Heni JP (2012) Évaluation du profil lipoprotéique et du risque athérogène chez les drépanocytaires homozygotes et hétérozygotes de Brazzaville. Ann Biol Clin 70 (2): 183-188. doi: 10.1684/abc.2012.0687 French.