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Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes
Advances in Biochemistry
Volume 8, Issue 4, December 2020, Pages: 57-61
Received: Nov. 5, 2020; Accepted: Nov. 20, 2020; Published: Nov. 27, 2020
Views 93      Downloads 61
Authors
N’Guessan Assieoussou Jean-Luc, Biosciences Training and Research Unit, Felix Houphouët-Boigny University, Abidjan, Côte d’Ivoire
Boyvin Lydie, Biosciences Training and Research Unit, Felix Houphouët-Boigny University, Abidjan, Côte d’Ivoire; Department of Clinical and Fundamental Biochemistry of Institut Pasteur, Abidjan, Côte d’Ivoire
Bahi Gnogbo Alexis, Department of Clinical and Fundamental Biochemistry of Institut Pasteur, Abidjan, Côte d’Ivoire
Moke-Bedji Louise Odile, Diabetes and Hypertension Clinic Beda Yao Bernard of University Teaching Hospital, Abidjan, Côte d’Ivoire
Yaye Yapi Guillaume, Agroforestry Training and Research Unit, Jean Lorougnon Guede University, Daloa, Côte d’Ivoire
Ankotche Amos, Diabetes and Hypertension Clinic Beda Yao Bernard of University Teaching Hospital, Abidjan, Côte d’Ivoire
Djaman Allico Joseph, Biosciences Training and Research Unit, Felix Houphouët-Boigny University, Abidjan, Côte d’Ivoire; Department of Clinical and Fundamental Biochemistry of Institut Pasteur, Abidjan, Côte d’Ivoire
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Abstract
Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.
Keywords
Copper, Côte D'ivoire, Oxidative Stress, Type 2 Diabetics, Zinc
To cite this article
N’Guessan Assieoussou Jean-Luc, Boyvin Lydie, Bahi Gnogbo Alexis, Moke-Bedji Louise Odile, Yaye Yapi Guillaume, Ankotche Amos, Djaman Allico Joseph, Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes, Advances in Biochemistry. Vol. 8, No. 4, 2020, pp. 57-61. doi: 10.11648/j.ab.20200804.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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