Advances in Biochemistry
Volume 7, Issue 1, March 2019, Pages: 1-4
Received: Apr. 11, 2019;
Accepted: May 23, 2019;
Published: Jun. 5, 2019
Views 209 Downloads 73
Nwachoko Ndidi, Department of Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria
Essien Eka Bassey, Department of Biochemistry, University of Port Harcourt, Choba, Nigeria
Ayalogu Edward Obiozo, Department of Medical Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria
Plants and their components are the only source of most drugs which comprise of distinct groups such as antispasmodics, emetics, anticancer and antimicrobials. Plants capable of improving health conditions and treating diseases have been identified and used since human existence. A wide variety of compound synthesized from plants participate in biological roles such as defense against predators. This study examined the protective effect of Aframomunchrysanthum seed aqueous extract against acetaminophen-induced liver toxicity in rats. A suspension of 750 mg/kg acetaminophen was administered once every 72 hours to induce toxicity in the rats. This was followed by oral administration of the plant extract (500, 1000 and 2000 mg/kg) body weight and 100 mg/kg of silymarine. For ten days. Eighteen hours after the last dosage, blood sample was collected for biochemical analysis. The result showed significant (p < 0.05) increase in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) as well as the concentrations of albumin (ALB) and total bilirubin (T. B) levels in rats administered with acetaminophen only. The levels of these parameters were significantly (p < 0.05) decreased in the groups pretreated with the extract.
Essien Eka Bassey,
Ayalogu Edward Obiozo,
Effects of Aframomun Chrysanthum Seed Aqueous Extract Against Acetaminophen-induced Liver Toxicity in Rats, Advances in Biochemistry.
Vol. 7, No. 1,
2019, pp. 1-4.
Lichterman, B. L. (2004). Aspirin: the story of a wonder drug. British medical Journal, 329 (7479): 1408.
Tapsell, L. C., Hemphill, I. and Cabiac, L. (2006). Health benefits of herbs and spices, the past present and future. Medicinal Journal of Australia, 185 (4): 54 – 24.
Fabricant, D. S., and Farnsworth, H. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspective, 109 (1): 69-75.
Dorland’s, D. (2012). Dorland’s illustrated Medical Dictionary. 32nd edition. Elsevier. p. 285.
Abdel-Misih, M., Sherif, R. Z. and Bloomston, M. (2010). Liver anatomy. Surgical Clinics of North America, 90 (40): 643-653.
Gupta, S. K. and Singhvi, I. J. (2011). Herbal and hepatoprotective drugs acting on peptic ulcer and liver disease. International Journal of Pharmacy and Technology, 3: 824 – 853.
Bakare, R. I., Magbagbeola, O. A., Akinwande, A. I., Okunowo, O. W. and Green, M. (2011). Antidiarrhoeal activity of aqueous leaf extract of Momordicacharantiain rats. Journal of Pharmacognosy and Phototherapy, 3 (1): 1-7.
Lapanik, B., Prosok, M. and Wondra, A. G. (2005). Comparison of extracts prepared from plant by-product using different solvents and extraction time. Journal of Food Engineering, 71: 214-222.
Oben, J. E., Assi, S. E., Agbor, G. B. and Musoro, D. F. (2006). Effect of Eremomastaxspecidsaon experimental diarrhea. African Journal of Traditional Complement, 3 (1): 95 – 100.
Handa, S. S., Khanuja, S. P. S., Longo, G. and Rakesh, D. D. (2008). Extraction technologies for medicineal and aromatic plants. International centre medicinal for and aromatic plants. International centre for science and high technology, Trieste, 21-25.
Maton, A., Jean, H., Charles, W. M., Susan, J., Maryanna, Q. W., David, L. And Jill, D. W. (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA. p 13.
Friedman, L. S., Martin, P. and Munoz, S. J. (1996). Liver function tests and the objective evaluation of the patient with liver disease. In Zakin, D, Boyer, T. D. eds. Hepatology: A Textbook of Liver Disease, 3rd ed. Philadelphia, W. B. Saunders. P 791 - 833.
Sturgill, J. R. and Lumbert, M. G. L. (1997). Medicinal plants of Lauras novas. Fitoterapia, 56: 515 –520
Ezeonwu, V. U. and Dahiru, D. (2013). Protective effect of bi-herbal formulation of Ocimum gratissimum and Gongronema latifolium aqueous leaf extract on acetaminophen- induced hepato- nephrotoxicity in rats. American Journal of Biochemistry, 3 (1): 18-23.
Weber, L. W., Boll, M. and Stampfl, A. (2003). Hepatotoxicity and mechanism of action of haloalkanes: Carbontetrachloride as toxicological model. Critical Review and Toxicology, 33: 105 – 136.
Nwachoko, N., Essien, E. B. and Ayalogu, E. O. (2015). Proximate and Quantitative phytochemical analysis of Aframomumchrysanthum. Open Access Library Journal, 2: e1529 (1-5).